CTL-mediated immunotherapy can suppress SHIV rebound in ART-free macaques

Viral rebound following discontinuation of antiretroviral therapy (ART) is a major obstacle for HIV cure. Here, the authors show that adoptive cellular therapy using autologous Env-specific T cells augmented by therapeutic vaccination can control viral rebound after ART interruption in a SHIV macaqu...

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Autores principales:	Jin Fan, Hua Liang, Xiaolin Ji, Shuo Wang, Jing Xue, Dan Li, Hong Peng, Chuan Qin, Cassian Yee, Yiming Shao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0ba168e5395147c58ff5014f91356684
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spelling	oai:doaj.org-article:0ba168e5395147c58ff5014f913566842021-12-02T16:58:24ZCTL-mediated immunotherapy can suppress SHIV rebound in ART-free macaques10.1038/s41467-019-09725-62041-1723https://doaj.org/article/0ba168e5395147c58ff5014f913566842019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09725-6https://doaj.org/toc/2041-1723Viral rebound following discontinuation of antiretroviral therapy (ART) is a major obstacle for HIV cure. Here, the authors show that adoptive cellular therapy using autologous Env-specific T cells augmented by therapeutic vaccination can control viral rebound after ART interruption in a SHIV macaque model.Jin FanHua LiangXiaolin JiShuo WangJing XueDan LiHong PengChuan QinCassian YeeYiming ShaoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jin Fan Hua Liang Xiaolin Ji Shuo Wang Jing Xue Dan Li Hong Peng Chuan Qin Cassian Yee Yiming Shao CTL-mediated immunotherapy can suppress SHIV rebound in ART-free macaques
description	Viral rebound following discontinuation of antiretroviral therapy (ART) is a major obstacle for HIV cure. Here, the authors show that adoptive cellular therapy using autologous Env-specific T cells augmented by therapeutic vaccination can control viral rebound after ART interruption in a SHIV macaque model.
format	article
author	Jin Fan Hua Liang Xiaolin Ji Shuo Wang Jing Xue Dan Li Hong Peng Chuan Qin Cassian Yee Yiming Shao
author_facet	Jin Fan Hua Liang Xiaolin Ji Shuo Wang Jing Xue Dan Li Hong Peng Chuan Qin Cassian Yee Yiming Shao
author_sort	Jin Fan
title	CTL-mediated immunotherapy can suppress SHIV rebound in ART-free macaques
title_short	CTL-mediated immunotherapy can suppress SHIV rebound in ART-free macaques
title_full	CTL-mediated immunotherapy can suppress SHIV rebound in ART-free macaques
title_fullStr	CTL-mediated immunotherapy can suppress SHIV rebound in ART-free macaques
title_full_unstemmed	CTL-mediated immunotherapy can suppress SHIV rebound in ART-free macaques
title_sort	ctl-mediated immunotherapy can suppress shiv rebound in art-free macaques
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0ba168e5395147c58ff5014f91356684
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CTL-mediated immunotherapy can suppress SHIV rebound in ART-free macaques

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