The Effect of Weight-Loss Interventions on Cervical and Chin Subcutaneous Fat Depots; the CENTRAL Randomized Controlled Trial

Accumulation of cervical and chin subcutaneous adipose tissues (SAT) represent known phenotypes of obesity. We aimed to evaluate the sensitivity of these fat storages to long-term weight-loss directed lifestyle-intervention and to assess their relations to bodily-adiposity, insulin-resistance, and c...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Gal Tsaban, Avital Bilitzky-Kopit, Anat Yaskolka Meir, Hila Zelicha, Yftach Gepner, Ilan Shelef, Omri Orr, Yoash Chassidim, Benjamin Sarusi, Uta Ceglarek, Michael Stumvoll, Matthias Blüher, Meir J. Stampfer, Iris Shai, Dan Schwarzfuchs
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cervical subcutaneous fat chin subcutaneous fat dietary intervention weight loss magnetic resonance imaging insulin resistance Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/0ba16a0b35304912b9e6e07bb7ef5230
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0ba16a0b35304912b9e6e07bb7ef5230
record_format	dspace
spelling	oai:doaj.org-article:0ba16a0b35304912b9e6e07bb7ef52302021-11-25T18:34:27ZThe Effect of Weight-Loss Interventions on Cervical and Chin Subcutaneous Fat Depots; the CENTRAL Randomized Controlled Trial10.3390/nu131138272072-6643https://doaj.org/article/0ba16a0b35304912b9e6e07bb7ef52302021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3827https://doaj.org/toc/2072-6643Accumulation of cervical and chin subcutaneous adipose tissues (SAT) represent known phenotypes of obesity. We aimed to evaluate the sensitivity of these fat storages to long-term weight-loss directed lifestyle-intervention and to assess their relations to bodily-adiposity, insulin-resistance, and cardiometabolic risk; We randomly assigned 278 participants with abdominal-obesity/dyslipidemia to low-fat or Mediterranean/low-carbohydrate diets +/− physical-activity. All participants underwent an 18 month whole-body magnetic resonance imaging follow-up, from which we assessed cervical and chin SAT-areas; Participants (age = 48 years; 90% men; body-mass-index = 30.9 kg/m<sup>2</sup>) had an 18-month adherence-rate of 86%. Cervical-SAT and chin-SAT decreased after 6-months (−13.1% and −5.3%, respectively, <i>p</i> < 0.001). After 18-months only cervical-SAT remained decreased compared to baseline (−5%, <i>p</i> < 0.001). Cervical and chin-SAT 18-month changes were associated with changes in weight (r = 0.70, r = 0.66 respectively; <0.001 for both) and visceral-adipose-tissue (VAT; r = 0.35, r = 0.42 respectively; <0.001 for both). After adjustment to VAT, waist-circumference, or weight-changes, chin-SAT 18-month reduction was associated with favorable changes in fasting-glucose (β = 0.10; <i>p</i> = 0.05), HbA1c (β = 0.12; <i>p</i> = 0.03), and homeostasis-model-assessment-of-insulin-resistance (β = 0.12; <i>p</i> = 0.03). Cervical-SAT 18-month reduction was associated with decreased triglycerides (β = 0.16; <i>p</i> = 0.02) and leptin (β = 0.19; <i>p</i> = 0.01) independent of VAT; Cervical and chin-SATs are dynamic fat depots that correspond with weight-loss and are associated with changes in cardiometabolic profile. In long-term, chin-SAT displays a larger rebound compared with cervical-SAT. Chin-SAT accumulation is associated with in insulin-resistance, independent of central obesity. (ClinicalTrials identifier NCT01530724)Gal TsabanAvital Bilitzky-KopitAnat Yaskolka MeirHila ZelichaYftach GepnerIlan ShelefOmri OrrYoash ChassidimBenjamin SarusiUta CeglarekMichael StumvollMatthias BlüherMeir J. StampferIris ShaiDan SchwarzfuchsMDPI AGarticlecervical subcutaneous fatchin subcutaneous fatdietary interventionweight lossmagnetic resonance imaginginsulin resistanceNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3827, p 3827 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cervical subcutaneous fat chin subcutaneous fat dietary intervention weight loss magnetic resonance imaging insulin resistance Nutrition. Foods and food supply TX341-641
spellingShingle	cervical subcutaneous fat chin subcutaneous fat dietary intervention weight loss magnetic resonance imaging insulin resistance Nutrition. Foods and food supply TX341-641 Gal Tsaban Avital Bilitzky-Kopit Anat Yaskolka Meir Hila Zelicha Yftach Gepner Ilan Shelef Omri Orr Yoash Chassidim Benjamin Sarusi Uta Ceglarek Michael Stumvoll Matthias Blüher Meir J. Stampfer Iris Shai Dan Schwarzfuchs The Effect of Weight-Loss Interventions on Cervical and Chin Subcutaneous Fat Depots; the CENTRAL Randomized Controlled Trial
description	Accumulation of cervical and chin subcutaneous adipose tissues (SAT) represent known phenotypes of obesity. We aimed to evaluate the sensitivity of these fat storages to long-term weight-loss directed lifestyle-intervention and to assess their relations to bodily-adiposity, insulin-resistance, and cardiometabolic risk; We randomly assigned 278 participants with abdominal-obesity/dyslipidemia to low-fat or Mediterranean/low-carbohydrate diets +/− physical-activity. All participants underwent an 18 month whole-body magnetic resonance imaging follow-up, from which we assessed cervical and chin SAT-areas; Participants (age = 48 years; 90% men; body-mass-index = 30.9 kg/m<sup>2</sup>) had an 18-month adherence-rate of 86%. Cervical-SAT and chin-SAT decreased after 6-months (−13.1% and −5.3%, respectively, <i>p</i> < 0.001). After 18-months only cervical-SAT remained decreased compared to baseline (−5%, <i>p</i> < 0.001). Cervical and chin-SAT 18-month changes were associated with changes in weight (r = 0.70, r = 0.66 respectively; <0.001 for both) and visceral-adipose-tissue (VAT; r = 0.35, r = 0.42 respectively; <0.001 for both). After adjustment to VAT, waist-circumference, or weight-changes, chin-SAT 18-month reduction was associated with favorable changes in fasting-glucose (β = 0.10; <i>p</i> = 0.05), HbA1c (β = 0.12; <i>p</i> = 0.03), and homeostasis-model-assessment-of-insulin-resistance (β = 0.12; <i>p</i> = 0.03). Cervical-SAT 18-month reduction was associated with decreased triglycerides (β = 0.16; <i>p</i> = 0.02) and leptin (β = 0.19; <i>p</i> = 0.01) independent of VAT; Cervical and chin-SATs are dynamic fat depots that correspond with weight-loss and are associated with changes in cardiometabolic profile. In long-term, chin-SAT displays a larger rebound compared with cervical-SAT. Chin-SAT accumulation is associated with in insulin-resistance, independent of central obesity. (ClinicalTrials identifier NCT01530724)
format	article
author	Gal Tsaban Avital Bilitzky-Kopit Anat Yaskolka Meir Hila Zelicha Yftach Gepner Ilan Shelef Omri Orr Yoash Chassidim Benjamin Sarusi Uta Ceglarek Michael Stumvoll Matthias Blüher Meir J. Stampfer Iris Shai Dan Schwarzfuchs
author_facet	Gal Tsaban Avital Bilitzky-Kopit Anat Yaskolka Meir Hila Zelicha Yftach Gepner Ilan Shelef Omri Orr Yoash Chassidim Benjamin Sarusi Uta Ceglarek Michael Stumvoll Matthias Blüher Meir J. Stampfer Iris Shai Dan Schwarzfuchs
author_sort	Gal Tsaban
title	The Effect of Weight-Loss Interventions on Cervical and Chin Subcutaneous Fat Depots; the CENTRAL Randomized Controlled Trial
title_short	The Effect of Weight-Loss Interventions on Cervical and Chin Subcutaneous Fat Depots; the CENTRAL Randomized Controlled Trial
title_full	The Effect of Weight-Loss Interventions on Cervical and Chin Subcutaneous Fat Depots; the CENTRAL Randomized Controlled Trial
title_fullStr	The Effect of Weight-Loss Interventions on Cervical and Chin Subcutaneous Fat Depots; the CENTRAL Randomized Controlled Trial
title_full_unstemmed	The Effect of Weight-Loss Interventions on Cervical and Chin Subcutaneous Fat Depots; the CENTRAL Randomized Controlled Trial
title_sort	effect of weight-loss interventions on cervical and chin subcutaneous fat depots; the central randomized controlled trial
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0ba16a0b35304912b9e6e07bb7ef5230
work_keys_str_mv	AT galtsaban theeffectofweightlossinterventionsoncervicalandchinsubcutaneousfatdepotsthecentralrandomizedcontrolledtrial AT avitalbilitzkykopit theeffectofweightlossinterventionsoncervicalandchinsubcutaneousfatdepotsthecentralrandomizedcontrolledtrial AT anatyaskolkameir theeffectofweightlossinterventionsoncervicalandchinsubcutaneousfatdepotsthecentralrandomizedcontrolledtrial AT hilazelicha theeffectofweightlossinterventionsoncervicalandchinsubcutaneousfatdepotsthecentralrandomizedcontrolledtrial AT yftachgepner theeffectofweightlossinterventionsoncervicalandchinsubcutaneousfatdepotsthecentralrandomizedcontrolledtrial AT ilanshelef theeffectofweightlossinterventionsoncervicalandchinsubcutaneousfatdepotsthecentralrandomizedcontrolledtrial AT omriorr theeffectofweightlossinterventionsoncervicalandchinsubcutaneousfatdepotsthecentralrandomizedcontrolledtrial AT yoashchassidim theeffectofweightlossinterventionsoncervicalandchinsubcutaneousfatdepotsthecentralrandomizedcontrolledtrial AT benjaminsarusi theeffectofweightlossinterventionsoncervicalandchinsubcutaneousfatdepotsthecentralrandomizedcontrolledtrial AT utaceglarek theeffectofweightlossinterventionsoncervicalandchinsubcutaneousfatdepotsthecentralrandomizedcontrolledtrial AT michaelstumvoll theeffectofweightlossinterventionsoncervicalandchinsubcutaneousfatdepotsthecentralrandomizedcontrolledtrial AT matthiasbluher theeffectofweightlossinterventionsoncervicalandchinsubcutaneousfatdepotsthecentralrandomizedcontrolledtrial AT meirjstampfer theeffectofweightlossinterventionsoncervicalandchinsubcutaneousfatdepotsthecentralrandomizedcontrolledtrial AT irisshai theeffectofweightlossinterventionsoncervicalandchinsubcutaneousfatdepotsthecentralrandomizedcontrolledtrial AT danschwarzfuchs theeffectofweightlossinterventionsoncervicalandchinsubcutaneousfatdepotsthecentralrandomizedcontrolledtrial AT galtsaban effectofweightlossinterventionsoncervicalandchinsubcutaneousfatdepotsthecentralrandomizedcontrolledtrial AT avitalbilitzkykopit effectofweightlossinterventionsoncervicalandchinsubcutaneousfatdepotsthecentralrandomizedcontrolledtrial AT anatyaskolkameir effectofweightlossinterventionsoncervicalandchinsubcutaneousfatdepotsthecentralrandomizedcontrolledtrial AT hilazelicha effectofweightlossinterventionsoncervicalandchinsubcutaneousfatdepotsthecentralrandomizedcontrolledtrial AT yftachgepner effectofweightlossinterventionsoncervicalandchinsubcutaneousfatdepotsthecentralrandomizedcontrolledtrial AT ilanshelef effectofweightlossinterventionsoncervicalandchinsubcutaneousfatdepotsthecentralrandomizedcontrolledtrial AT omriorr effectofweightlossinterventionsoncervicalandchinsubcutaneousfatdepotsthecentralrandomizedcontrolledtrial AT yoashchassidim effectofweightlossinterventionsoncervicalandchinsubcutaneousfatdepotsthecentralrandomizedcontrolledtrial AT benjaminsarusi effectofweightlossinterventionsoncervicalandchinsubcutaneousfatdepotsthecentralrandomizedcontrolledtrial AT utaceglarek effectofweightlossinterventionsoncervicalandchinsubcutaneousfatdepotsthecentralrandomizedcontrolledtrial AT michaelstumvoll effectofweightlossinterventionsoncervicalandchinsubcutaneousfatdepotsthecentralrandomizedcontrolledtrial AT matthiasbluher effectofweightlossinterventionsoncervicalandchinsubcutaneousfatdepotsthecentralrandomizedcontrolledtrial AT meirjstampfer effectofweightlossinterventionsoncervicalandchinsubcutaneousfatdepotsthecentralrandomizedcontrolledtrial AT irisshai effectofweightlossinterventionsoncervicalandchinsubcutaneousfatdepotsthecentralrandomizedcontrolledtrial AT danschwarzfuchs effectofweightlossinterventionsoncervicalandchinsubcutaneousfatdepotsthecentralrandomizedcontrolledtrial
_version_	1718410934626549760

The Effect of Weight-Loss Interventions on Cervical and Chin Subcutaneous Fat Depots; the CENTRAL Randomized Controlled Trial

Ejemplares similares