Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis

T cells play a critical role in intestinal homeostasis, with increasing evidence suggesting a role for the microbiome metabolome in modulating this response. Here the authors show short-chain fatty acids promote IL-10 production in Th1 cells.

Guardado en:

Detalles Bibliográficos
Autores principales:	Mingming Sun, Wei Wu, Liang Chen, Wenjing Yang, Xiangsheng Huang, Caiyun Ma, Feidi Chen, Yi Xiao, Ye Zhao, Chunyan Ma, Suxia Yao, Victor H. Carpio, Sara M. Dann, Qihong Zhao, Zhanju Liu, Yingzi Cong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0ba5e8cba7f0472bb973f7f9800301ee
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0ba5e8cba7f0472bb973f7f9800301ee
record_format	dspace
spelling	oai:doaj.org-article:0ba5e8cba7f0472bb973f7f9800301ee2021-12-02T17:31:58ZMicrobiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis10.1038/s41467-018-05901-22041-1723https://doaj.org/article/0ba5e8cba7f0472bb973f7f9800301ee2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05901-2https://doaj.org/toc/2041-1723T cells play a critical role in intestinal homeostasis, with increasing evidence suggesting a role for the microbiome metabolome in modulating this response. Here the authors show short-chain fatty acids promote IL-10 production in Th1 cells.Mingming SunWei WuLiang ChenWenjing YangXiangsheng HuangCaiyun MaFeidi ChenYi XiaoYe ZhaoChunyan MaSuxia YaoVictor H. CarpioSara M. DannQihong ZhaoZhanju LiuYingzi CongNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mingming Sun Wei Wu Liang Chen Wenjing Yang Xiangsheng Huang Caiyun Ma Feidi Chen Yi Xiao Ye Zhao Chunyan Ma Suxia Yao Victor H. Carpio Sara M. Dann Qihong Zhao Zhanju Liu Yingzi Cong Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis
description	T cells play a critical role in intestinal homeostasis, with increasing evidence suggesting a role for the microbiome metabolome in modulating this response. Here the authors show short-chain fatty acids promote IL-10 production in Th1 cells.
format	article
author	Mingming Sun Wei Wu Liang Chen Wenjing Yang Xiangsheng Huang Caiyun Ma Feidi Chen Yi Xiao Ye Zhao Chunyan Ma Suxia Yao Victor H. Carpio Sara M. Dann Qihong Zhao Zhanju Liu Yingzi Cong
author_facet	Mingming Sun Wei Wu Liang Chen Wenjing Yang Xiangsheng Huang Caiyun Ma Feidi Chen Yi Xiao Ye Zhao Chunyan Ma Suxia Yao Victor H. Carpio Sara M. Dann Qihong Zhao Zhanju Liu Yingzi Cong
author_sort	Mingming Sun
title	Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis
title_short	Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis
title_full	Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis
title_fullStr	Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis
title_full_unstemmed	Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis
title_sort	microbiota-derived short-chain fatty acids promote th1 cell il-10 production to maintain intestinal homeostasis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0ba5e8cba7f0472bb973f7f9800301ee
work_keys_str_mv	AT mingmingsun microbiotaderivedshortchainfattyacidspromoteth1cellil10productiontomaintainintestinalhomeostasis AT weiwu microbiotaderivedshortchainfattyacidspromoteth1cellil10productiontomaintainintestinalhomeostasis AT liangchen microbiotaderivedshortchainfattyacidspromoteth1cellil10productiontomaintainintestinalhomeostasis AT wenjingyang microbiotaderivedshortchainfattyacidspromoteth1cellil10productiontomaintainintestinalhomeostasis AT xiangshenghuang microbiotaderivedshortchainfattyacidspromoteth1cellil10productiontomaintainintestinalhomeostasis AT caiyunma microbiotaderivedshortchainfattyacidspromoteth1cellil10productiontomaintainintestinalhomeostasis AT feidichen microbiotaderivedshortchainfattyacidspromoteth1cellil10productiontomaintainintestinalhomeostasis AT yixiao microbiotaderivedshortchainfattyacidspromoteth1cellil10productiontomaintainintestinalhomeostasis AT yezhao microbiotaderivedshortchainfattyacidspromoteth1cellil10productiontomaintainintestinalhomeostasis AT chunyanma microbiotaderivedshortchainfattyacidspromoteth1cellil10productiontomaintainintestinalhomeostasis AT suxiayao microbiotaderivedshortchainfattyacidspromoteth1cellil10productiontomaintainintestinalhomeostasis AT victorhcarpio microbiotaderivedshortchainfattyacidspromoteth1cellil10productiontomaintainintestinalhomeostasis AT saramdann microbiotaderivedshortchainfattyacidspromoteth1cellil10productiontomaintainintestinalhomeostasis AT qihongzhao microbiotaderivedshortchainfattyacidspromoteth1cellil10productiontomaintainintestinalhomeostasis AT zhanjuliu microbiotaderivedshortchainfattyacidspromoteth1cellil10productiontomaintainintestinalhomeostasis AT yingzicong microbiotaderivedshortchainfattyacidspromoteth1cellil10productiontomaintainintestinalhomeostasis
_version_	1718380411498790912

Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis

Ejemplares similares