Structure of the human sodium leak channel NALCN in complex with FAM155A

NALCN, a sodium leak channel, plays a key role in regulating the resting membrane potential and controlling neuronal excitability. Here the authors report a cryo-EM structure of human NALCN in complex with FAM155A, that with complementary functional analyses provide insights on its ion selectivity,...

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Autores principales:	Jiongfang Xie, Meng Ke, Lizhen Xu, Shiyi Lin, Jin Huang, Jiabei Zhang, Fan Yang, Jianping Wu, Zhen Yan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0ba8b9ca7116497c9d93aa32440a97ed
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spelling	oai:doaj.org-article:0ba8b9ca7116497c9d93aa32440a97ed2021-12-02T15:37:17ZStructure of the human sodium leak channel NALCN in complex with FAM155A10.1038/s41467-020-19667-z2041-1723https://doaj.org/article/0ba8b9ca7116497c9d93aa32440a97ed2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19667-zhttps://doaj.org/toc/2041-1723NALCN, a sodium leak channel, plays a key role in regulating the resting membrane potential and controlling neuronal excitability. Here the authors report a cryo-EM structure of human NALCN in complex with FAM155A, that with complementary functional analyses provide insights on its ion selectivity, voltage sensing and specific interactions with auxiliary subunits.Jiongfang XieMeng KeLizhen XuShiyi LinJin HuangJiabei ZhangFan YangJianping WuZhen YanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jiongfang Xie Meng Ke Lizhen Xu Shiyi Lin Jin Huang Jiabei Zhang Fan Yang Jianping Wu Zhen Yan Structure of the human sodium leak channel NALCN in complex with FAM155A
description	NALCN, a sodium leak channel, plays a key role in regulating the resting membrane potential and controlling neuronal excitability. Here the authors report a cryo-EM structure of human NALCN in complex with FAM155A, that with complementary functional analyses provide insights on its ion selectivity, voltage sensing and specific interactions with auxiliary subunits.
format	article
author	Jiongfang Xie Meng Ke Lizhen Xu Shiyi Lin Jin Huang Jiabei Zhang Fan Yang Jianping Wu Zhen Yan
author_facet	Jiongfang Xie Meng Ke Lizhen Xu Shiyi Lin Jin Huang Jiabei Zhang Fan Yang Jianping Wu Zhen Yan
author_sort	Jiongfang Xie
title	Structure of the human sodium leak channel NALCN in complex with FAM155A
title_short	Structure of the human sodium leak channel NALCN in complex with FAM155A
title_full	Structure of the human sodium leak channel NALCN in complex with FAM155A
title_fullStr	Structure of the human sodium leak channel NALCN in complex with FAM155A
title_full_unstemmed	Structure of the human sodium leak channel NALCN in complex with FAM155A
title_sort	structure of the human sodium leak channel nalcn in complex with fam155a
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0ba8b9ca7116497c9d93aa32440a97ed
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Structure of the human sodium leak channel NALCN in complex with FAM155A

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