PPARgamma-2 and ADRB3 polymorphisms in connective tissue diseases and lipid disorders

Bogna Grygiel-Górniak,1 Iwona Ziółkowska-Suchanek,2 Elżbieta Kaczmarek,3 Maria Mosor,2 Jerzy Nowak,2 Mariusz Puszczewicz1 1Department of Rheumatology and Internal Diseases, Poznan University of Medical Sciences, Poznan, Poland; 2Institute of Human Genetics, Polish Academy of S...

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Autores principales:	Grygiel-Górniak B, Ziółkowska-Suchanek I, Kaczmarek E, Mosor M, Nowak J, Puszczewicz M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	C1431T Pro12Ala Trp64Arg polymorphisms lipoproteins rheumatic diseases statins Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/0ba8c927bcd841f682a0d088aac7d66c
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spelling	oai:doaj.org-article:0ba8c927bcd841f682a0d088aac7d66c2021-12-02T02:08:02ZPPARgamma-2 and ADRB3 polymorphisms in connective tissue diseases and lipid disorders1178-1998https://doaj.org/article/0ba8c927bcd841f682a0d088aac7d66c2018-03-01T00:00:00Zhttps://www.dovepress.com/ppargamma-2-and-adrb3-polymorphisms-in-connective-tissue-diseases-and--peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Bogna Grygiel-Górniak,1 Iwona Ziółkowska-Suchanek,2 Elżbieta Kaczmarek,3 Maria Mosor,2 Jerzy Nowak,2 Mariusz Puszczewicz1 1Department of Rheumatology and Internal Diseases, Poznan University of Medical Sciences, Poznan, Poland; 2Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland; 3Department of Bioinformatics and Computational Biology, Poznan University of Medical Sciences, Poznan, Poland Background: The aim of the research genetic study was to investigate the association between variants (C1431T and Pro12Ala) of the peroxisome proliferator-activated receptor (PPARgamma-2) gene, Trp64Arg polymorphism of the beta-3-adrenergic receptor gene and lipid profile in Polish population including group of 103 patients with connective tissue disease (CTD) and 103 sex- and age-matched controls in context of statin use. Methods: Anthropometric and biochemical parameters were measured by routine methods, followed by genotyping (TagMan® Genotyping Assays, PCR-restriction fragment length polymorphism analysis). Nearly 30% of CTD patients used statins and 10% of the control group. Results: Although there were no differences between alleles and genotypes prevalence between CTD vs control groups, interesting lipid-gene associations were noted in this study. A higher level of triglycerides (TAG) and TAG/high-density lipoprotein (HDL) ratios was observed in CTD patients compared to controls. Similar differences were noted in CTD and control groups without statin treatment. Atherogenic markers: the atherogenic index of plasma, TAG/HDL and low-density lipoprotein/HDL ratio were low in the analyzed groups. Of the six analyzed polymorphisms, the Pro12Pro or C14131C or Trp64Trp genotypes were related to higher TAG and TAG/HDL ratios in patients with CTD; however, the highest TAG values were observed in the presence of the Trp64Trp genotype. Conclusion: Lipid disorders were present in both groups independent of statin treatment (mixed dyslipidemia and hypercholesterolemia were observed in the CTD and control groups, respectively). The risk of dyslipidemia increases with age. The presence of Pro12Pro, C14131C and Trp64Trp genotypes is related to higher TAG level in CTDs, and of these the Trp64Trp variant most reliably predicts hypertriglyceridemia. Keywords: C1431T, Pro12Ala, Trp64Arg polymorphisms, lipoproteins, rheumatic diseases, statinsGrygiel-Górniak BZiółkowska-Suchanek IKaczmarek EMosor MNowak JPuszczewicz MDove Medical PressarticleC1431TPro12AlaTrp64Arg polymorphismslipoproteinsrheumatic diseasesstatinsGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 13, Pp 463-472 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	C1431T Pro12Ala Trp64Arg polymorphisms lipoproteins rheumatic diseases statins Geriatrics RC952-954.6
spellingShingle	C1431T Pro12Ala Trp64Arg polymorphisms lipoproteins rheumatic diseases statins Geriatrics RC952-954.6 Grygiel-Górniak B Ziółkowska-Suchanek I Kaczmarek E Mosor M Nowak J Puszczewicz M PPARgamma-2 and ADRB3 polymorphisms in connective tissue diseases and lipid disorders
description	Bogna Grygiel-Górniak,1 Iwona Ziółkowska-Suchanek,2 Elżbieta Kaczmarek,3 Maria Mosor,2 Jerzy Nowak,2 Mariusz Puszczewicz1 1Department of Rheumatology and Internal Diseases, Poznan University of Medical Sciences, Poznan, Poland; 2Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland; 3Department of Bioinformatics and Computational Biology, Poznan University of Medical Sciences, Poznan, Poland Background: The aim of the research genetic study was to investigate the association between variants (C1431T and Pro12Ala) of the peroxisome proliferator-activated receptor (PPARgamma-2) gene, Trp64Arg polymorphism of the beta-3-adrenergic receptor gene and lipid profile in Polish population including group of 103 patients with connective tissue disease (CTD) and 103 sex- and age-matched controls in context of statin use. Methods: Anthropometric and biochemical parameters were measured by routine methods, followed by genotyping (TagMan® Genotyping Assays, PCR-restriction fragment length polymorphism analysis). Nearly 30% of CTD patients used statins and 10% of the control group. Results: Although there were no differences between alleles and genotypes prevalence between CTD vs control groups, interesting lipid-gene associations were noted in this study. A higher level of triglycerides (TAG) and TAG/high-density lipoprotein (HDL) ratios was observed in CTD patients compared to controls. Similar differences were noted in CTD and control groups without statin treatment. Atherogenic markers: the atherogenic index of plasma, TAG/HDL and low-density lipoprotein/HDL ratio were low in the analyzed groups. Of the six analyzed polymorphisms, the Pro12Pro or C14131C or Trp64Trp genotypes were related to higher TAG and TAG/HDL ratios in patients with CTD; however, the highest TAG values were observed in the presence of the Trp64Trp genotype. Conclusion: Lipid disorders were present in both groups independent of statin treatment (mixed dyslipidemia and hypercholesterolemia were observed in the CTD and control groups, respectively). The risk of dyslipidemia increases with age. The presence of Pro12Pro, C14131C and Trp64Trp genotypes is related to higher TAG level in CTDs, and of these the Trp64Trp variant most reliably predicts hypertriglyceridemia. Keywords: C1431T, Pro12Ala, Trp64Arg polymorphisms, lipoproteins, rheumatic diseases, statins
format	article
author	Grygiel-Górniak B Ziółkowska-Suchanek I Kaczmarek E Mosor M Nowak J Puszczewicz M
author_facet	Grygiel-Górniak B Ziółkowska-Suchanek I Kaczmarek E Mosor M Nowak J Puszczewicz M
author_sort	Grygiel-Górniak B
title	PPARgamma-2 and ADRB3 polymorphisms in connective tissue diseases and lipid disorders
title_short	PPARgamma-2 and ADRB3 polymorphisms in connective tissue diseases and lipid disorders
title_full	PPARgamma-2 and ADRB3 polymorphisms in connective tissue diseases and lipid disorders
title_fullStr	PPARgamma-2 and ADRB3 polymorphisms in connective tissue diseases and lipid disorders
title_full_unstemmed	PPARgamma-2 and ADRB3 polymorphisms in connective tissue diseases and lipid disorders
title_sort	ppargamma-2 and adrb3 polymorphisms in connective tissue diseases and lipid disorders
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/0ba8c927bcd841f682a0d088aac7d66c
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PPARgamma-2 and ADRB3 polymorphisms in connective tissue diseases and lipid disorders

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