Free manipulation system for nanorobot cluster based on complicated multi-coil electromagnetic actuator

Abstract Chemotherapy is an important method in the field of cancer treatment and often follows surgery and/or radiotherapy to remove as many tumor cells as possible. In particular, among the chemotherapy methods, treatment using electromagnetic-based actuation systems is considered an effective met...

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Autores principales:	Yun Kim, Jun Keun Chae, Jong-Hwan Lee, Eunpyo Choi, Yoon Koo Lee, Jihwan Song
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0baa56f248854cdba4bcdebfd38446eb
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spelling	oai:doaj.org-article:0baa56f248854cdba4bcdebfd38446eb2021-12-02T19:16:11ZFree manipulation system for nanorobot cluster based on complicated multi-coil electromagnetic actuator10.1038/s41598-021-98957-y2045-2322https://doaj.org/article/0baa56f248854cdba4bcdebfd38446eb2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98957-yhttps://doaj.org/toc/2045-2322Abstract Chemotherapy is an important method in the field of cancer treatment and often follows surgery and/or radiotherapy to remove as many tumor cells as possible. In particular, among the chemotherapy methods, treatment using electromagnetic-based actuation systems is considered an effective method owing to the remote control of nanorobots. The existing electromagnetic-based actuation systems, however, have certain disadvantages such as the lack of degrees of freedom and the difficulty of manipulating large numbers of nanorobots (i.e., nanorobot clusters). Herein, we report that nanorobot clusters can be manipulated with high degrees of freedom through a simple parameter alpha that easily controls the gradient of the magnetic field of a multi-coil electromagnetic actuation system. The simulation results show that the gradient of the magnetic field is controlled using an introduced parameter, alpha, and the corresponding velocity is also controlled. Not only the velocity of the nanorobot cluster but also the unrestricted spatial control is enabled in two- and three-dimensions. We believe this study highlights an efficient method of electromagnetic control for cluster-based drug delivery.Yun KimJun Keun ChaeJong-Hwan LeeEunpyo ChoiYoon Koo LeeJihwan SongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yun Kim Jun Keun Chae Jong-Hwan Lee Eunpyo Choi Yoon Koo Lee Jihwan Song Free manipulation system for nanorobot cluster based on complicated multi-coil electromagnetic actuator
description	Abstract Chemotherapy is an important method in the field of cancer treatment and often follows surgery and/or radiotherapy to remove as many tumor cells as possible. In particular, among the chemotherapy methods, treatment using electromagnetic-based actuation systems is considered an effective method owing to the remote control of nanorobots. The existing electromagnetic-based actuation systems, however, have certain disadvantages such as the lack of degrees of freedom and the difficulty of manipulating large numbers of nanorobots (i.e., nanorobot clusters). Herein, we report that nanorobot clusters can be manipulated with high degrees of freedom through a simple parameter alpha that easily controls the gradient of the magnetic field of a multi-coil electromagnetic actuation system. The simulation results show that the gradient of the magnetic field is controlled using an introduced parameter, alpha, and the corresponding velocity is also controlled. Not only the velocity of the nanorobot cluster but also the unrestricted spatial control is enabled in two- and three-dimensions. We believe this study highlights an efficient method of electromagnetic control for cluster-based drug delivery.
format	article
author	Yun Kim Jun Keun Chae Jong-Hwan Lee Eunpyo Choi Yoon Koo Lee Jihwan Song
author_facet	Yun Kim Jun Keun Chae Jong-Hwan Lee Eunpyo Choi Yoon Koo Lee Jihwan Song
author_sort	Yun Kim
title	Free manipulation system for nanorobot cluster based on complicated multi-coil electromagnetic actuator
title_short	Free manipulation system for nanorobot cluster based on complicated multi-coil electromagnetic actuator
title_full	Free manipulation system for nanorobot cluster based on complicated multi-coil electromagnetic actuator
title_fullStr	Free manipulation system for nanorobot cluster based on complicated multi-coil electromagnetic actuator
title_full_unstemmed	Free manipulation system for nanorobot cluster based on complicated multi-coil electromagnetic actuator
title_sort	free manipulation system for nanorobot cluster based on complicated multi-coil electromagnetic actuator
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0baa56f248854cdba4bcdebfd38446eb
work_keys_str_mv	AT yunkim freemanipulationsystemfornanorobotclusterbasedoncomplicatedmulticoilelectromagneticactuator AT junkeunchae freemanipulationsystemfornanorobotclusterbasedoncomplicatedmulticoilelectromagneticactuator AT jonghwanlee freemanipulationsystemfornanorobotclusterbasedoncomplicatedmulticoilelectromagneticactuator AT eunpyochoi freemanipulationsystemfornanorobotclusterbasedoncomplicatedmulticoilelectromagneticactuator AT yoonkoolee freemanipulationsystemfornanorobotclusterbasedoncomplicatedmulticoilelectromagneticactuator AT jihwansong freemanipulationsystemfornanorobotclusterbasedoncomplicatedmulticoilelectromagneticactuator
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Free manipulation system for nanorobot cluster based on complicated multi-coil electromagnetic actuator

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