Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice

Here, using ex-vivo human adult cortical tissue and a mouse model, the authors investigate the functional consequences of Zika virus (ZIKV) infection in the adult brain, and show that ZIKV causes synapse damage and altered brain function that impacts cognition via activation of innate and inflammato...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Claudia P. Figueiredo, Fernanda G. Q. Barros-Aragão, Rômulo L. S. Neris, Paula S. Frost, Carolina Soares, Isis N. O. Souza, Julianna D. Zeidler, Daniele C. Zamberlan, Virginia L. de Sousa, Amanda S. Souza, André Luis A. Guimarães, Maria Bellio, Jorge Marcondes de Souza, Soniza V. Alves-Leon, Gilda A. Neves, Heitor A. Paula-Neto, Newton G. Castro, Fernanda G. De Felice, Iranaia Assunção-Miranda, Julia R. Clarke, Andrea T. Da Poian, Sergio T. Ferreira
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0bac999998154571acca058da9d921c8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0bac999998154571acca058da9d921c8
record_format	dspace
spelling	oai:doaj.org-article:0bac999998154571acca058da9d921c82021-12-02T17:33:22ZZika virus replicates in adult human brain tissue and impairs synapses and memory in mice10.1038/s41467-019-11866-72041-1723https://doaj.org/article/0bac999998154571acca058da9d921c82019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11866-7https://doaj.org/toc/2041-1723Here, using ex-vivo human adult cortical tissue and a mouse model, the authors investigate the functional consequences of Zika virus (ZIKV) infection in the adult brain, and show that ZIKV causes synapse damage and altered brain function that impacts cognition via activation of innate and inflammatory factors.Claudia P. FigueiredoFernanda G. Q. Barros-AragãoRômulo L. S. NerisPaula S. FrostCarolina SoaresIsis N. O. SouzaJulianna D. ZeidlerDaniele C. ZamberlanVirginia L. de SousaAmanda S. SouzaAndré Luis A. GuimarãesMaria BellioJorge Marcondes de SouzaSoniza V. Alves-LeonGilda A. NevesHeitor A. Paula-NetoNewton G. CastroFernanda G. De FeliceIranaia Assunção-MirandaJulia R. ClarkeAndrea T. Da PoianSergio T. FerreiraNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Claudia P. Figueiredo Fernanda G. Q. Barros-Aragão Rômulo L. S. Neris Paula S. Frost Carolina Soares Isis N. O. Souza Julianna D. Zeidler Daniele C. Zamberlan Virginia L. de Sousa Amanda S. Souza André Luis A. Guimarães Maria Bellio Jorge Marcondes de Souza Soniza V. Alves-Leon Gilda A. Neves Heitor A. Paula-Neto Newton G. Castro Fernanda G. De Felice Iranaia Assunção-Miranda Julia R. Clarke Andrea T. Da Poian Sergio T. Ferreira Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice
description	Here, using ex-vivo human adult cortical tissue and a mouse model, the authors investigate the functional consequences of Zika virus (ZIKV) infection in the adult brain, and show that ZIKV causes synapse damage and altered brain function that impacts cognition via activation of innate and inflammatory factors.
format	article
author	Claudia P. Figueiredo Fernanda G. Q. Barros-Aragão Rômulo L. S. Neris Paula S. Frost Carolina Soares Isis N. O. Souza Julianna D. Zeidler Daniele C. Zamberlan Virginia L. de Sousa Amanda S. Souza André Luis A. Guimarães Maria Bellio Jorge Marcondes de Souza Soniza V. Alves-Leon Gilda A. Neves Heitor A. Paula-Neto Newton G. Castro Fernanda G. De Felice Iranaia Assunção-Miranda Julia R. Clarke Andrea T. Da Poian Sergio T. Ferreira
author_facet	Claudia P. Figueiredo Fernanda G. Q. Barros-Aragão Rômulo L. S. Neris Paula S. Frost Carolina Soares Isis N. O. Souza Julianna D. Zeidler Daniele C. Zamberlan Virginia L. de Sousa Amanda S. Souza André Luis A. Guimarães Maria Bellio Jorge Marcondes de Souza Soniza V. Alves-Leon Gilda A. Neves Heitor A. Paula-Neto Newton G. Castro Fernanda G. De Felice Iranaia Assunção-Miranda Julia R. Clarke Andrea T. Da Poian Sergio T. Ferreira
author_sort	Claudia P. Figueiredo
title	Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice
title_short	Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice
title_full	Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice
title_fullStr	Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice
title_full_unstemmed	Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice
title_sort	zika virus replicates in adult human brain tissue and impairs synapses and memory in mice
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0bac999998154571acca058da9d921c8
work_keys_str_mv	AT claudiapfigueiredo zikavirusreplicatesinadulthumanbraintissueandimpairssynapsesandmemoryinmice AT fernandagqbarrosaragao zikavirusreplicatesinadulthumanbraintissueandimpairssynapsesandmemoryinmice AT romulolsneris zikavirusreplicatesinadulthumanbraintissueandimpairssynapsesandmemoryinmice AT paulasfrost zikavirusreplicatesinadulthumanbraintissueandimpairssynapsesandmemoryinmice AT carolinasoares zikavirusreplicatesinadulthumanbraintissueandimpairssynapsesandmemoryinmice AT isisnosouza zikavirusreplicatesinadulthumanbraintissueandimpairssynapsesandmemoryinmice AT juliannadzeidler zikavirusreplicatesinadulthumanbraintissueandimpairssynapsesandmemoryinmice AT danieleczamberlan zikavirusreplicatesinadulthumanbraintissueandimpairssynapsesandmemoryinmice AT virginialdesousa zikavirusreplicatesinadulthumanbraintissueandimpairssynapsesandmemoryinmice AT amandassouza zikavirusreplicatesinadulthumanbraintissueandimpairssynapsesandmemoryinmice AT andreluisaguimaraes zikavirusreplicatesinadulthumanbraintissueandimpairssynapsesandmemoryinmice AT mariabellio zikavirusreplicatesinadulthumanbraintissueandimpairssynapsesandmemoryinmice AT jorgemarcondesdesouza zikavirusreplicatesinadulthumanbraintissueandimpairssynapsesandmemoryinmice AT sonizavalvesleon zikavirusreplicatesinadulthumanbraintissueandimpairssynapsesandmemoryinmice AT gildaaneves zikavirusreplicatesinadulthumanbraintissueandimpairssynapsesandmemoryinmice AT heitorapaulaneto zikavirusreplicatesinadulthumanbraintissueandimpairssynapsesandmemoryinmice AT newtongcastro zikavirusreplicatesinadulthumanbraintissueandimpairssynapsesandmemoryinmice AT fernandagdefelice zikavirusreplicatesinadulthumanbraintissueandimpairssynapsesandmemoryinmice AT iranaiaassuncaomiranda zikavirusreplicatesinadulthumanbraintissueandimpairssynapsesandmemoryinmice AT juliarclarke zikavirusreplicatesinadulthumanbraintissueandimpairssynapsesandmemoryinmice AT andreatdapoian zikavirusreplicatesinadulthumanbraintissueandimpairssynapsesandmemoryinmice AT sergiotferreira zikavirusreplicatesinadulthumanbraintissueandimpairssynapsesandmemoryinmice
_version_	1718379921433165824

Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice

Ejemplares similares