DUF581 is plant specific FCS-like zinc finger involved in protein-protein interaction.

Zinc fingers are a ubiquitous class of protein domain with considerable variation in structure and function. Zf-FCS is a highly diverged group of C2-C2 zinc finger which is present in animals, prokaryotes and viruses, but not in plants. In this study we identified that a plant specific domain of unk...

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Autores principales:	Muhammed Jamsheer K, Ashverya Laxmi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0baeff25967047a89c7975869330f2dc
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spelling	oai:doaj.org-article:0baeff25967047a89c7975869330f2dc2021-11-18T08:16:59ZDUF581 is plant specific FCS-like zinc finger involved in protein-protein interaction.1932-620310.1371/journal.pone.0099074https://doaj.org/article/0baeff25967047a89c7975869330f2dc2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24901469/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Zinc fingers are a ubiquitous class of protein domain with considerable variation in structure and function. Zf-FCS is a highly diverged group of C2-C2 zinc finger which is present in animals, prokaryotes and viruses, but not in plants. In this study we identified that a plant specific domain of unknown function, DUF581 is a zf-FCS type zinc finger. Based on HMM-HMM comparison and signature motif similarity we named this domain as FCS-Like Zinc finger (FLZ) domain. A genome wide survey identified that FLZ domain containing genes are bryophytic in origin and this gene family is expanded in spermatophytes. Expression analysis of selected FLZ gene family members of A. thaliana identified an overlapping expression pattern suggesting a possible redundancy in their function. Unlike the zf-FCS domain, the FLZ domain found to be highly conserved in sequence and structure. Using a combination of bioinformatic and protein-protein interaction tools, we identified that FLZ domain is involved in protein-protein interaction.Muhammed Jamsheer KAshverya LaxmiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e99074 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Muhammed Jamsheer K Ashverya Laxmi DUF581 is plant specific FCS-like zinc finger involved in protein-protein interaction.
description	Zinc fingers are a ubiquitous class of protein domain with considerable variation in structure and function. Zf-FCS is a highly diverged group of C2-C2 zinc finger which is present in animals, prokaryotes and viruses, but not in plants. In this study we identified that a plant specific domain of unknown function, DUF581 is a zf-FCS type zinc finger. Based on HMM-HMM comparison and signature motif similarity we named this domain as FCS-Like Zinc finger (FLZ) domain. A genome wide survey identified that FLZ domain containing genes are bryophytic in origin and this gene family is expanded in spermatophytes. Expression analysis of selected FLZ gene family members of A. thaliana identified an overlapping expression pattern suggesting a possible redundancy in their function. Unlike the zf-FCS domain, the FLZ domain found to be highly conserved in sequence and structure. Using a combination of bioinformatic and protein-protein interaction tools, we identified that FLZ domain is involved in protein-protein interaction.
format	article
author	Muhammed Jamsheer K Ashverya Laxmi
author_facet	Muhammed Jamsheer K Ashverya Laxmi
author_sort	Muhammed Jamsheer K
title	DUF581 is plant specific FCS-like zinc finger involved in protein-protein interaction.
title_short	DUF581 is plant specific FCS-like zinc finger involved in protein-protein interaction.
title_full	DUF581 is plant specific FCS-like zinc finger involved in protein-protein interaction.
title_fullStr	DUF581 is plant specific FCS-like zinc finger involved in protein-protein interaction.
title_full_unstemmed	DUF581 is plant specific FCS-like zinc finger involved in protein-protein interaction.
title_sort	duf581 is plant specific fcs-like zinc finger involved in protein-protein interaction.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/0baeff25967047a89c7975869330f2dc
work_keys_str_mv	AT muhammedjamsheerk duf581isplantspecificfcslikezincfingerinvolvedinproteinproteininteraction AT ashveryalaxmi duf581isplantspecificfcslikezincfingerinvolvedinproteinproteininteraction
_version_	1718421965449986048

DUF581 is plant specific FCS-like zinc finger involved in protein-protein interaction.

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