Early modifications of the gut microbiome in children with hepatic sinusoidal obstruction syndrome after hematopoietic stem cell transplantation

Abstract Hepatic sinusoidal obstruction syndrome (SOS/VOD) represents a dramatic complication of hematopoietic stem cell transplantation (HSCT), particularly in children. Recent evidence has suggested a role for the gut microbiome (GM) in the context of HSCT and its related complications, but no dat...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Riccardo Masetti, Elena Biagi, Daniele Zama, Edoardo Muratore, Federica D’Amico, Davide Leardini, Silvia Turroni, Arcangelo Prete, Patrizia Brigidi, Andrea Pession
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0bafdf5dfda54a0c9cf0d62ac33a7b83
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0bafdf5dfda54a0c9cf0d62ac33a7b83
record_format	dspace
spelling	oai:doaj.org-article:0bafdf5dfda54a0c9cf0d62ac33a7b832021-12-02T16:08:05ZEarly modifications of the gut microbiome in children with hepatic sinusoidal obstruction syndrome after hematopoietic stem cell transplantation10.1038/s41598-021-93571-42045-2322https://doaj.org/article/0bafdf5dfda54a0c9cf0d62ac33a7b832021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93571-4https://doaj.org/toc/2045-2322Abstract Hepatic sinusoidal obstruction syndrome (SOS/VOD) represents a dramatic complication of hematopoietic stem cell transplantation (HSCT), particularly in children. Recent evidence has suggested a role for the gut microbiome (GM) in the context of HSCT and its related complications, but no data are available on the relationship between GM and SOS/VOD. Here, we conducted a retrospective case–control study in allo-HSCT pediatric patients developing or not SOS/VOD and profiled their GM over time, from before the transplant up to 72 days after. A rich and diverse GM before HSCT was found to be associated with a reduced likelihood of developing SOS/VOD. Furthermore, prior to transplant, patients not developing SOS/VOD showed an enrichment in some typically health-associated commensals, such as Bacteroides, Ruminococcaceae and Lachnospiraceae. Their levels remained overall higher until post-transplant. This high-diversity configuration resembles that described in other studies for other HSCT-related complications, including graft-versus-host disease, potentially representing a common protective GM feature against HSCT complications.Riccardo MasettiElena BiagiDaniele ZamaEdoardo MuratoreFederica D’AmicoDavide LeardiniSilvia TurroniArcangelo PretePatrizia BrigidiAndrea PessionNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Riccardo Masetti Elena Biagi Daniele Zama Edoardo Muratore Federica D’Amico Davide Leardini Silvia Turroni Arcangelo Prete Patrizia Brigidi Andrea Pession Early modifications of the gut microbiome in children with hepatic sinusoidal obstruction syndrome after hematopoietic stem cell transplantation
description	Abstract Hepatic sinusoidal obstruction syndrome (SOS/VOD) represents a dramatic complication of hematopoietic stem cell transplantation (HSCT), particularly in children. Recent evidence has suggested a role for the gut microbiome (GM) in the context of HSCT and its related complications, but no data are available on the relationship between GM and SOS/VOD. Here, we conducted a retrospective case–control study in allo-HSCT pediatric patients developing or not SOS/VOD and profiled their GM over time, from before the transplant up to 72 days after. A rich and diverse GM before HSCT was found to be associated with a reduced likelihood of developing SOS/VOD. Furthermore, prior to transplant, patients not developing SOS/VOD showed an enrichment in some typically health-associated commensals, such as Bacteroides, Ruminococcaceae and Lachnospiraceae. Their levels remained overall higher until post-transplant. This high-diversity configuration resembles that described in other studies for other HSCT-related complications, including graft-versus-host disease, potentially representing a common protective GM feature against HSCT complications.
format	article
author	Riccardo Masetti Elena Biagi Daniele Zama Edoardo Muratore Federica D’Amico Davide Leardini Silvia Turroni Arcangelo Prete Patrizia Brigidi Andrea Pession
author_facet	Riccardo Masetti Elena Biagi Daniele Zama Edoardo Muratore Federica D’Amico Davide Leardini Silvia Turroni Arcangelo Prete Patrizia Brigidi Andrea Pession
author_sort	Riccardo Masetti
title	Early modifications of the gut microbiome in children with hepatic sinusoidal obstruction syndrome after hematopoietic stem cell transplantation
title_short	Early modifications of the gut microbiome in children with hepatic sinusoidal obstruction syndrome after hematopoietic stem cell transplantation
title_full	Early modifications of the gut microbiome in children with hepatic sinusoidal obstruction syndrome after hematopoietic stem cell transplantation
title_fullStr	Early modifications of the gut microbiome in children with hepatic sinusoidal obstruction syndrome after hematopoietic stem cell transplantation
title_full_unstemmed	Early modifications of the gut microbiome in children with hepatic sinusoidal obstruction syndrome after hematopoietic stem cell transplantation
title_sort	early modifications of the gut microbiome in children with hepatic sinusoidal obstruction syndrome after hematopoietic stem cell transplantation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0bafdf5dfda54a0c9cf0d62ac33a7b83
work_keys_str_mv	AT riccardomasetti earlymodificationsofthegutmicrobiomeinchildrenwithhepaticsinusoidalobstructionsyndromeafterhematopoieticstemcelltransplantation AT elenabiagi earlymodificationsofthegutmicrobiomeinchildrenwithhepaticsinusoidalobstructionsyndromeafterhematopoieticstemcelltransplantation AT danielezama earlymodificationsofthegutmicrobiomeinchildrenwithhepaticsinusoidalobstructionsyndromeafterhematopoieticstemcelltransplantation AT edoardomuratore earlymodificationsofthegutmicrobiomeinchildrenwithhepaticsinusoidalobstructionsyndromeafterhematopoieticstemcelltransplantation AT federicadamico earlymodificationsofthegutmicrobiomeinchildrenwithhepaticsinusoidalobstructionsyndromeafterhematopoieticstemcelltransplantation AT davideleardini earlymodificationsofthegutmicrobiomeinchildrenwithhepaticsinusoidalobstructionsyndromeafterhematopoieticstemcelltransplantation AT silviaturroni earlymodificationsofthegutmicrobiomeinchildrenwithhepaticsinusoidalobstructionsyndromeafterhematopoieticstemcelltransplantation AT arcangeloprete earlymodificationsofthegutmicrobiomeinchildrenwithhepaticsinusoidalobstructionsyndromeafterhematopoieticstemcelltransplantation AT patriziabrigidi earlymodificationsofthegutmicrobiomeinchildrenwithhepaticsinusoidalobstructionsyndromeafterhematopoieticstemcelltransplantation AT andreapession earlymodificationsofthegutmicrobiomeinchildrenwithhepaticsinusoidalobstructionsyndromeafterhematopoieticstemcelltransplantation
_version_	1718384575339560960

Early modifications of the gut microbiome in children with hepatic sinusoidal obstruction syndrome after hematopoietic stem cell transplantation

Ejemplares similares