Evaluation of Gallic Acid-Coated Gold Nanoparticles as an Anti-Aging Ingredient
Hyperglycemic environment-induced oxidative stress-mediated matrix metalloproteinase-1 (MMP-1) plays a crucial role in the degradation of the extracellular matrix (ECM), which might contribute to premature skin aging. Synthesized, environmentally friendly gallic acid-coated gold nanoparticles (GA–Au...
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MDPI AG
2021
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oai:doaj.org-article:0bb2d934bd0e453e908bdf40e0ca8dab2021-11-25T18:39:06ZEvaluation of Gallic Acid-Coated Gold Nanoparticles as an Anti-Aging Ingredient10.3390/ph141110711424-8247https://doaj.org/article/0bb2d934bd0e453e908bdf40e0ca8dab2021-10-01T00:00:00Zhttps://www.mdpi.com/1424-8247/14/11/1071https://doaj.org/toc/1424-8247Hyperglycemic environment-induced oxidative stress-mediated matrix metalloproteinase-1 (MMP-1) plays a crucial role in the degradation of the extracellular matrix (ECM), which might contribute to premature skin aging. Synthesized, environmentally friendly gallic acid-coated gold nanoparticles (GA–AuNPs) have been evaluated as an anti-aging antioxidant. Their microstructure was characterized by transmission electron microscopy (TEM), which showed that GA–AuNPs are spherical when prepared at pH 11. Dynamic light scattering (DLS) analysis revealed that the average hydrodynamic diameter of a GA–AuNP is approximately 40 nm and with a zeta potential of −49.63 ± 2.11 mV. Additionally, the present data showed that GA–AuNPs have a superior ability to inhibit high glucose-mediated MMP-1-elicited type I collagen degradation in dermal fibroblast cells. Collectively, our data indicated that high-glucose-mediated ROS production was reduced upon cell treatment with GA–AuNPs, which blocked p38 MAPK/ERK-mediated c-Jun, c-Fos, ATF-2 phosphorylation, and the phosphorylation of NFκB, leading to the down-regulation of MMP-1 mRNA and protein expression in high glucose-treated cells. Our findings suggest that GA-AuNPs have a superior ability to inhibit high-glucose-mediated MMP-1-elicited ECM degradation, which highlights its potential as an anti-aging ingredient.Yun-Zhen WuYen-Yu TsaiLong-Sen ChangYing-Jung ChenMDPI AGarticlegold nanoparticlegallic acidmatrix metalloproteinase-1anti-aginghigh glucoseMedicineRPharmacy and materia medicaRS1-441ENPharmaceuticals, Vol 14, Iss 1071, p 1071 (2021) |
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gold nanoparticle gallic acid matrix metalloproteinase-1 anti-aging high glucose Medicine R Pharmacy and materia medica RS1-441 |
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gold nanoparticle gallic acid matrix metalloproteinase-1 anti-aging high glucose Medicine R Pharmacy and materia medica RS1-441 Yun-Zhen Wu Yen-Yu Tsai Long-Sen Chang Ying-Jung Chen Evaluation of Gallic Acid-Coated Gold Nanoparticles as an Anti-Aging Ingredient |
| description |
Hyperglycemic environment-induced oxidative stress-mediated matrix metalloproteinase-1 (MMP-1) plays a crucial role in the degradation of the extracellular matrix (ECM), which might contribute to premature skin aging. Synthesized, environmentally friendly gallic acid-coated gold nanoparticles (GA–AuNPs) have been evaluated as an anti-aging antioxidant. Their microstructure was characterized by transmission electron microscopy (TEM), which showed that GA–AuNPs are spherical when prepared at pH 11. Dynamic light scattering (DLS) analysis revealed that the average hydrodynamic diameter of a GA–AuNP is approximately 40 nm and with a zeta potential of −49.63 ± 2.11 mV. Additionally, the present data showed that GA–AuNPs have a superior ability to inhibit high glucose-mediated MMP-1-elicited type I collagen degradation in dermal fibroblast cells. Collectively, our data indicated that high-glucose-mediated ROS production was reduced upon cell treatment with GA–AuNPs, which blocked p38 MAPK/ERK-mediated c-Jun, c-Fos, ATF-2 phosphorylation, and the phosphorylation of NFκB, leading to the down-regulation of MMP-1 mRNA and protein expression in high glucose-treated cells. Our findings suggest that GA-AuNPs have a superior ability to inhibit high-glucose-mediated MMP-1-elicited ECM degradation, which highlights its potential as an anti-aging ingredient. |
| format |
article |
| author |
Yun-Zhen Wu Yen-Yu Tsai Long-Sen Chang Ying-Jung Chen |
| author_facet |
Yun-Zhen Wu Yen-Yu Tsai Long-Sen Chang Ying-Jung Chen |
| author_sort |
Yun-Zhen Wu |
| title |
Evaluation of Gallic Acid-Coated Gold Nanoparticles as an Anti-Aging Ingredient |
| title_short |
Evaluation of Gallic Acid-Coated Gold Nanoparticles as an Anti-Aging Ingredient |
| title_full |
Evaluation of Gallic Acid-Coated Gold Nanoparticles as an Anti-Aging Ingredient |
| title_fullStr |
Evaluation of Gallic Acid-Coated Gold Nanoparticles as an Anti-Aging Ingredient |
| title_full_unstemmed |
Evaluation of Gallic Acid-Coated Gold Nanoparticles as an Anti-Aging Ingredient |
| title_sort |
evaluation of gallic acid-coated gold nanoparticles as an anti-aging ingredient |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/0bb2d934bd0e453e908bdf40e0ca8dab |
| work_keys_str_mv |
AT yunzhenwu evaluationofgallicacidcoatedgoldnanoparticlesasanantiagingingredient AT yenyutsai evaluationofgallicacidcoatedgoldnanoparticlesasanantiagingingredient AT longsenchang evaluationofgallicacidcoatedgoldnanoparticlesasanantiagingingredient AT yingjungchen evaluationofgallicacidcoatedgoldnanoparticlesasanantiagingingredient |
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1718410815068962816 |