Incident Parkinson’s disease in kidney transplantation recipients: a nationwide population-based cohort study in Korea

Abstract This nation-wide population based retrospective cohort study evaluated risk of incident Parkinson’ disease in kidney transplant (KT) recipients in Korea. From Korean National Health Insurance Service database, we identified incident KT recipients aged ≥ 40 years without any history of Parki...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Seon Ha Baek, Sehoon Park, Mi-yeon Yu, Ji Eun Kim, Sang Hyun Park, Kyungdo Han, Yong Chul Kim, Dong Ki Kim, Kwon Wook Joo, Yon Su Kim, Hajeong Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0bb4c042400648fbb13a380735dfa5a9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0bb4c042400648fbb13a380735dfa5a9
record_format	dspace
spelling	oai:doaj.org-article:0bb4c042400648fbb13a380735dfa5a92021-12-02T15:53:10ZIncident Parkinson’s disease in kidney transplantation recipients: a nationwide population-based cohort study in Korea10.1038/s41598-021-90130-92045-2322https://doaj.org/article/0bb4c042400648fbb13a380735dfa5a92021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90130-9https://doaj.org/toc/2045-2322Abstract This nation-wide population based retrospective cohort study evaluated risk of incident Parkinson’ disease in kidney transplant (KT) recipients in Korea. From Korean National Health Insurance Service database, we identified incident KT recipients aged ≥ 40 years without any history of Parkinson’s disease between 2007 and 2015. We established two control cohorts without a history of Parkinson’ disease: (1) General population (GP) cohort of insured subjects without a history of kidney disease, (2) end-stage renal disease (ESRD) cohort of incident ESRD subjects, with frequency matched for age, sex, and inclusion year. Parkinson’s disease data were obtained from baseline until December 2017. We followed 8372 KT recipients, ESRD patients, and GP for 45,723, 38,357, and 47,476 patient-years, respectively. Their mean age was 51.2 years and 60.1% were men. During follow-up period, 19 KT recipients, 53 ESRD patients, and 15 GP developed Parkinson’ disease. Risk of incident Parkinson’s disease in KT recipients was similar to that in GP (adjusted hazard ratio [HR] 0.86, 95% confidence interval [CI] 0.35 to 2.13, P = 0.75) and significantly lower than that in ESRD patients (adjusted HR 0.31, 95% CI 0.18 to 0.52, P < 0.001). Older age was the strongest predictor for incident Parkinson’s disease in KT recipients.Seon Ha BaekSehoon ParkMi-yeon YuJi Eun KimSang Hyun ParkKyungdo HanYong Chul KimDong Ki KimKwon Wook JooYon Su KimHajeong LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Seon Ha Baek Sehoon Park Mi-yeon Yu Ji Eun Kim Sang Hyun Park Kyungdo Han Yong Chul Kim Dong Ki Kim Kwon Wook Joo Yon Su Kim Hajeong Lee Incident Parkinson’s disease in kidney transplantation recipients: a nationwide population-based cohort study in Korea
description	Abstract This nation-wide population based retrospective cohort study evaluated risk of incident Parkinson’ disease in kidney transplant (KT) recipients in Korea. From Korean National Health Insurance Service database, we identified incident KT recipients aged ≥ 40 years without any history of Parkinson’s disease between 2007 and 2015. We established two control cohorts without a history of Parkinson’ disease: (1) General population (GP) cohort of insured subjects without a history of kidney disease, (2) end-stage renal disease (ESRD) cohort of incident ESRD subjects, with frequency matched for age, sex, and inclusion year. Parkinson’s disease data were obtained from baseline until December 2017. We followed 8372 KT recipients, ESRD patients, and GP for 45,723, 38,357, and 47,476 patient-years, respectively. Their mean age was 51.2 years and 60.1% were men. During follow-up period, 19 KT recipients, 53 ESRD patients, and 15 GP developed Parkinson’ disease. Risk of incident Parkinson’s disease in KT recipients was similar to that in GP (adjusted hazard ratio [HR] 0.86, 95% confidence interval [CI] 0.35 to 2.13, P = 0.75) and significantly lower than that in ESRD patients (adjusted HR 0.31, 95% CI 0.18 to 0.52, P < 0.001). Older age was the strongest predictor for incident Parkinson’s disease in KT recipients.
format	article
author	Seon Ha Baek Sehoon Park Mi-yeon Yu Ji Eun Kim Sang Hyun Park Kyungdo Han Yong Chul Kim Dong Ki Kim Kwon Wook Joo Yon Su Kim Hajeong Lee
author_facet	Seon Ha Baek Sehoon Park Mi-yeon Yu Ji Eun Kim Sang Hyun Park Kyungdo Han Yong Chul Kim Dong Ki Kim Kwon Wook Joo Yon Su Kim Hajeong Lee
author_sort	Seon Ha Baek
title	Incident Parkinson’s disease in kidney transplantation recipients: a nationwide population-based cohort study in Korea
title_short	Incident Parkinson’s disease in kidney transplantation recipients: a nationwide population-based cohort study in Korea
title_full	Incident Parkinson’s disease in kidney transplantation recipients: a nationwide population-based cohort study in Korea
title_fullStr	Incident Parkinson’s disease in kidney transplantation recipients: a nationwide population-based cohort study in Korea
title_full_unstemmed	Incident Parkinson’s disease in kidney transplantation recipients: a nationwide population-based cohort study in Korea
title_sort	incident parkinson’s disease in kidney transplantation recipients: a nationwide population-based cohort study in korea
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0bb4c042400648fbb13a380735dfa5a9
work_keys_str_mv	AT seonhabaek incidentparkinsonsdiseaseinkidneytransplantationrecipientsanationwidepopulationbasedcohortstudyinkorea AT sehoonpark incidentparkinsonsdiseaseinkidneytransplantationrecipientsanationwidepopulationbasedcohortstudyinkorea AT miyeonyu incidentparkinsonsdiseaseinkidneytransplantationrecipientsanationwidepopulationbasedcohortstudyinkorea AT jieunkim incidentparkinsonsdiseaseinkidneytransplantationrecipientsanationwidepopulationbasedcohortstudyinkorea AT sanghyunpark incidentparkinsonsdiseaseinkidneytransplantationrecipientsanationwidepopulationbasedcohortstudyinkorea AT kyungdohan incidentparkinsonsdiseaseinkidneytransplantationrecipientsanationwidepopulationbasedcohortstudyinkorea AT yongchulkim incidentparkinsonsdiseaseinkidneytransplantationrecipientsanationwidepopulationbasedcohortstudyinkorea AT dongkikim incidentparkinsonsdiseaseinkidneytransplantationrecipientsanationwidepopulationbasedcohortstudyinkorea AT kwonwookjoo incidentparkinsonsdiseaseinkidneytransplantationrecipientsanationwidepopulationbasedcohortstudyinkorea AT yonsukim incidentparkinsonsdiseaseinkidneytransplantationrecipientsanationwidepopulationbasedcohortstudyinkorea AT hajeonglee incidentparkinsonsdiseaseinkidneytransplantationrecipientsanationwidepopulationbasedcohortstudyinkorea
_version_	1718385493153939456

Incident Parkinson’s disease in kidney transplantation recipients: a nationwide population-based cohort study in Korea

Ejemplares similares