Risk of transmittable blood‐borne pathogens in blood units from blood donor dogs in Canada

Abstract Background Canine blood donors can be infected by various vector‐borne or other pathogens that could be an important cause of morbidity and death in transfusion recipients. Hypothesis/Objectives To estimate and predict positivity to transmittable blood‐borne pathogens in blood units collect...

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Autores principales:	Charlotte Nury, Marie‐Claude Blais, Julie Arsenault
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	blood banking canine vector‐borne diseases infectious diseases transfusion medicine Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/0bb5fe40908642c2be6644eded62d098
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spelling	oai:doaj.org-article:0bb5fe40908642c2be6644eded62d0982021-11-30T17:01:03ZRisk of transmittable blood‐borne pathogens in blood units from blood donor dogs in Canada1939-16760891-664010.1111/jvim.16139https://doaj.org/article/0bb5fe40908642c2be6644eded62d0982021-05-01T00:00:00Zhttps://doi.org/10.1111/jvim.16139https://doaj.org/toc/0891-6640https://doaj.org/toc/1939-1676Abstract Background Canine blood donors can be infected by various vector‐borne or other pathogens that could be an important cause of morbidity and death in transfusion recipients. Hypothesis/Objectives To estimate and predict positivity to transmittable blood‐borne pathogens in blood units collected from blood donor dogs in Canada. Animals Six thousand one hundred and fifty blood units from 1914 active blood donors registered to the Canadian Animal Blood Bank (CABB) between March 2010 and December 2016. Methods A registry‐based retrospective study. Blood units were screened by SNAP 4Dx/4Dx Plus and PCR panel tests. Information on blood donors and test results were extracted from multiple databases and collated. Logistic regressions were used to predict blood unit positivity. Results Of 1779 blood units, 0.56% were antibody‐positive for Anaplasma phagocytophilum/platys and 0% for Ehrlichia canis/ewingii. After exclusion of antibody‐positive units to Anaplasma spp., 1.1% of 6140 blood units were PCR‐positive to Anaplasma phagocytophilum, Bartonella spp., Brucella canis, “Candidatus Mycoplasma haematoparvum,” Mycoplasma haemocanis, or a combination of these pathogens. Babesia spp., Ehrlichia spp., and Leishmania spp. were not detected. Units from the first blood collection from a dog had higher odds of testing PCR‐positive (P < .001) for at least 1 pathogen than units from subsequent collections. Conclusions and Clinical Importance Although our study indicates a low probability of detecting blood‐borne pathogen in blood units collected by this Canadian blood bank, the presence of positive units highlights the importance of the preemptive identification and screening of blood units from healthy blood donors for safe blood banking, especially in first‐time donors.Charlotte NuryMarie‐Claude BlaisJulie ArsenaultWileyarticleblood bankingcanine vector‐borne diseasesinfectious diseasestransfusion medicineVeterinary medicineSF600-1100ENJournal of Veterinary Internal Medicine, Vol 35, Iss 3, Pp 1316-1324 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	blood banking canine vector‐borne diseases infectious diseases transfusion medicine Veterinary medicine SF600-1100
spellingShingle	blood banking canine vector‐borne diseases infectious diseases transfusion medicine Veterinary medicine SF600-1100 Charlotte Nury Marie‐Claude Blais Julie Arsenault Risk of transmittable blood‐borne pathogens in blood units from blood donor dogs in Canada
description	Abstract Background Canine blood donors can be infected by various vector‐borne or other pathogens that could be an important cause of morbidity and death in transfusion recipients. Hypothesis/Objectives To estimate and predict positivity to transmittable blood‐borne pathogens in blood units collected from blood donor dogs in Canada. Animals Six thousand one hundred and fifty blood units from 1914 active blood donors registered to the Canadian Animal Blood Bank (CABB) between March 2010 and December 2016. Methods A registry‐based retrospective study. Blood units were screened by SNAP 4Dx/4Dx Plus and PCR panel tests. Information on blood donors and test results were extracted from multiple databases and collated. Logistic regressions were used to predict blood unit positivity. Results Of 1779 blood units, 0.56% were antibody‐positive for Anaplasma phagocytophilum/platys and 0% for Ehrlichia canis/ewingii. After exclusion of antibody‐positive units to Anaplasma spp., 1.1% of 6140 blood units were PCR‐positive to Anaplasma phagocytophilum, Bartonella spp., Brucella canis, “Candidatus Mycoplasma haematoparvum,” Mycoplasma haemocanis, or a combination of these pathogens. Babesia spp., Ehrlichia spp., and Leishmania spp. were not detected. Units from the first blood collection from a dog had higher odds of testing PCR‐positive (P < .001) for at least 1 pathogen than units from subsequent collections. Conclusions and Clinical Importance Although our study indicates a low probability of detecting blood‐borne pathogen in blood units collected by this Canadian blood bank, the presence of positive units highlights the importance of the preemptive identification and screening of blood units from healthy blood donors for safe blood banking, especially in first‐time donors.
format	article
author	Charlotte Nury Marie‐Claude Blais Julie Arsenault
author_facet	Charlotte Nury Marie‐Claude Blais Julie Arsenault
author_sort	Charlotte Nury
title	Risk of transmittable blood‐borne pathogens in blood units from blood donor dogs in Canada
title_short	Risk of transmittable blood‐borne pathogens in blood units from blood donor dogs in Canada
title_full	Risk of transmittable blood‐borne pathogens in blood units from blood donor dogs in Canada
title_fullStr	Risk of transmittable blood‐borne pathogens in blood units from blood donor dogs in Canada
title_full_unstemmed	Risk of transmittable blood‐borne pathogens in blood units from blood donor dogs in Canada
title_sort	risk of transmittable blood‐borne pathogens in blood units from blood donor dogs in canada
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/0bb5fe40908642c2be6644eded62d098
work_keys_str_mv	AT charlottenury riskoftransmittablebloodbornepathogensinbloodunitsfromblooddonordogsincanada AT marieclaudeblais riskoftransmittablebloodbornepathogensinbloodunitsfromblooddonordogsincanada AT juliearsenault riskoftransmittablebloodbornepathogensinbloodunitsfromblooddonordogsincanada
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Risk of transmittable blood‐borne pathogens in blood units from blood donor dogs in Canada

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