Correlation between fundus autofluorescence and visual function in patients with cone-rod dystrophy

Abstract This study aimed to investigate the relationship between autofluorescence (AF) signal measured with ultra-wide field imaging and visual functions in patients with cone-rod dystrophy (CORD). A retrospective chart review was performed for CORD patients. We performed the visual field test and...

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Autores principales:	Satoru Kanda, Takumi Hara, Ryosuke Fujino, Keiko Azuma, Hirotsugu Soga, Ryo Asaoka, Ryo Obata, Tatsuya Inoue
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0bbc229bfb35455f80f522896afc8c79
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spelling	oai:doaj.org-article:0bbc229bfb35455f80f522896afc8c792021-12-02T10:49:23ZCorrelation between fundus autofluorescence and visual function in patients with cone-rod dystrophy10.1038/s41598-021-81597-72045-2322https://doaj.org/article/0bbc229bfb35455f80f522896afc8c792021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81597-7https://doaj.org/toc/2045-2322Abstract This study aimed to investigate the relationship between autofluorescence (AF) signal measured with ultra-wide field imaging and visual functions in patients with cone-rod dystrophy (CORD). A retrospective chart review was performed for CORD patients. We performed the visual field test and fundus autofluorescence (FAF) measurement and visualized retinal structures with optical coherence tomography (OCT) on the same day. Using binarised FAF images, we identified a low FAF area ratio (LFAR: low FAF/30°). Relationships between age and logMAR visual acuity (VA), central retinal thickness (CRT), central choroidal thickness (CCT), mean deviation (MD) value, and LFAR were investigated. Thirty-seven eyes of 21 CORD patients (8 men and 13 women) were enrolled. The mean patient age was 49.8 years. LogMAR VA and MD were 0.52 ± 0.47 and − 17.91 ± 10.59 dB, respectively. There was a significant relationship between logMAR VA and MD (p = 0.001). LogMAR VA significantly correlated with CRT (p = 0.006) but not with other parameters. Conversely, univariate analysis suggested a significant relationship between MD and LFAR (p = 0.001). In the multivariate analysis, LFAR was significantly associated with MD (p = 0.002). In conclusion, it is useful to measure the low FAF area in patients with CORD. The AF measurement reflects the visual field deterioration but not VA in CORD.Satoru KandaTakumi HaraRyosuke FujinoKeiko AzumaHirotsugu SogaRyo AsaokaRyo ObataTatsuya InoueNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Satoru Kanda Takumi Hara Ryosuke Fujino Keiko Azuma Hirotsugu Soga Ryo Asaoka Ryo Obata Tatsuya Inoue Correlation between fundus autofluorescence and visual function in patients with cone-rod dystrophy
description	Abstract This study aimed to investigate the relationship between autofluorescence (AF) signal measured with ultra-wide field imaging and visual functions in patients with cone-rod dystrophy (CORD). A retrospective chart review was performed for CORD patients. We performed the visual field test and fundus autofluorescence (FAF) measurement and visualized retinal structures with optical coherence tomography (OCT) on the same day. Using binarised FAF images, we identified a low FAF area ratio (LFAR: low FAF/30°). Relationships between age and logMAR visual acuity (VA), central retinal thickness (CRT), central choroidal thickness (CCT), mean deviation (MD) value, and LFAR were investigated. Thirty-seven eyes of 21 CORD patients (8 men and 13 women) were enrolled. The mean patient age was 49.8 years. LogMAR VA and MD were 0.52 ± 0.47 and − 17.91 ± 10.59 dB, respectively. There was a significant relationship between logMAR VA and MD (p = 0.001). LogMAR VA significantly correlated with CRT (p = 0.006) but not with other parameters. Conversely, univariate analysis suggested a significant relationship between MD and LFAR (p = 0.001). In the multivariate analysis, LFAR was significantly associated with MD (p = 0.002). In conclusion, it is useful to measure the low FAF area in patients with CORD. The AF measurement reflects the visual field deterioration but not VA in CORD.
format	article
author	Satoru Kanda Takumi Hara Ryosuke Fujino Keiko Azuma Hirotsugu Soga Ryo Asaoka Ryo Obata Tatsuya Inoue
author_facet	Satoru Kanda Takumi Hara Ryosuke Fujino Keiko Azuma Hirotsugu Soga Ryo Asaoka Ryo Obata Tatsuya Inoue
author_sort	Satoru Kanda
title	Correlation between fundus autofluorescence and visual function in patients with cone-rod dystrophy
title_short	Correlation between fundus autofluorescence and visual function in patients with cone-rod dystrophy
title_full	Correlation between fundus autofluorescence and visual function in patients with cone-rod dystrophy
title_fullStr	Correlation between fundus autofluorescence and visual function in patients with cone-rod dystrophy
title_full_unstemmed	Correlation between fundus autofluorescence and visual function in patients with cone-rod dystrophy
title_sort	correlation between fundus autofluorescence and visual function in patients with cone-rod dystrophy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0bbc229bfb35455f80f522896afc8c79
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Correlation between fundus autofluorescence and visual function in patients with cone-rod dystrophy

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