Hepatocellular carcinoma: current trends in worldwide epidemiology, risk factors, diagnosis, and therapeutics

Renumathy Dhanasekaran, Alpna Limaye, Roniel CabreraDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Florida, Gainesville, FL, USAAbstract: Hepatocellular carcinoma (HCC) is a common malignancy in developing countries and its incidence is on the rise in...

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Autores principales:	Dhanasekaran R, Limaye A, Cabrera R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/0bbc29f3d7d74ad68c496af902799f3b
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spelling	oai:doaj.org-article:0bbc29f3d7d74ad68c496af902799f3b2021-12-02T06:26:21ZHepatocellular carcinoma: current trends in worldwide epidemiology, risk factors, diagnosis, and therapeutics1179-1535https://doaj.org/article/0bbc29f3d7d74ad68c496af902799f3b2012-05-01T00:00:00Zhttp://www.dovepress.com/hepatocellular-carcinoma-current-trends-in-worldwide-epidemiology-risk-a9857https://doaj.org/toc/1179-1535Renumathy Dhanasekaran, Alpna Limaye, Roniel CabreraDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Florida, Gainesville, FL, USAAbstract: Hepatocellular carcinoma (HCC) is a common malignancy in developing countries and its incidence is on the rise in the developing world. The epidemiology of this cancer is unique since its risk factors, including hepatitis C and B, have been clearly established. The current trends in the shifting incidence of HCC in different regions of the world can be explained partly by the changing prevalence of hepatitis. Early detection offers the only hope for curative treatment for patients with HCC, hence effective screening strategies for high-risk patients is of utmost importance. Liver transplantation and surgical resection remains the cornerstone of curative treatment. But major advances in locoregional therapies and molecular-targeted therapies for the treatment of advanced HCC have occurred recently. In this review, current trends in the worldwide epidemiology, surveillance, diagnosis, standard treatments, and the emerging therapies for HCC are discussed.Keywords: liver cancer, sorafenib, hepatitis C, TACEDhanasekaran RLimaye ACabrera RDove Medical PressarticleDiseases of the digestive system. GastroenterologyRC799-869ENHepatic Medicine: Evidence and Research, Vol 2012, Iss default, Pp 19-37 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Diseases of the digestive system. Gastroenterology RC799-869 Dhanasekaran R Limaye A Cabrera R Hepatocellular carcinoma: current trends in worldwide epidemiology, risk factors, diagnosis, and therapeutics
description	Renumathy Dhanasekaran, Alpna Limaye, Roniel CabreraDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Florida, Gainesville, FL, USAAbstract: Hepatocellular carcinoma (HCC) is a common malignancy in developing countries and its incidence is on the rise in the developing world. The epidemiology of this cancer is unique since its risk factors, including hepatitis C and B, have been clearly established. The current trends in the shifting incidence of HCC in different regions of the world can be explained partly by the changing prevalence of hepatitis. Early detection offers the only hope for curative treatment for patients with HCC, hence effective screening strategies for high-risk patients is of utmost importance. Liver transplantation and surgical resection remains the cornerstone of curative treatment. But major advances in locoregional therapies and molecular-targeted therapies for the treatment of advanced HCC have occurred recently. In this review, current trends in the worldwide epidemiology, surveillance, diagnosis, standard treatments, and the emerging therapies for HCC are discussed.Keywords: liver cancer, sorafenib, hepatitis C, TACE
format	article
author	Dhanasekaran R Limaye A Cabrera R
author_facet	Dhanasekaran R Limaye A Cabrera R
author_sort	Dhanasekaran R
title	Hepatocellular carcinoma: current trends in worldwide epidemiology, risk factors, diagnosis, and therapeutics
title_short	Hepatocellular carcinoma: current trends in worldwide epidemiology, risk factors, diagnosis, and therapeutics
title_full	Hepatocellular carcinoma: current trends in worldwide epidemiology, risk factors, diagnosis, and therapeutics
title_fullStr	Hepatocellular carcinoma: current trends in worldwide epidemiology, risk factors, diagnosis, and therapeutics
title_full_unstemmed	Hepatocellular carcinoma: current trends in worldwide epidemiology, risk factors, diagnosis, and therapeutics
title_sort	hepatocellular carcinoma: current trends in worldwide epidemiology, risk factors, diagnosis, and therapeutics
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/0bbc29f3d7d74ad68c496af902799f3b
work_keys_str_mv	AT dhanasekaranr hepatocellularcarcinomacurrenttrendsinworldwideepidemiologyriskfactorsdiagnosisandtherapeutics AT limayea hepatocellularcarcinomacurrenttrendsinworldwideepidemiologyriskfactorsdiagnosisandtherapeutics AT cabrerar hepatocellularcarcinomacurrenttrendsinworldwideepidemiologyriskfactorsdiagnosisandtherapeutics
_version_	1718399915677188096

Hepatocellular carcinoma: current trends in worldwide epidemiology, risk factors, diagnosis, and therapeutics

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