HIV-1 molecular diversity in Brazil unveiled by 10 years of sampling by the national genotyping network

Abstract HIV-1 has diversified into several subtypes and recombinant forms that are heterogeneously spread around the world. Understanding the distribution of viral variants and their temporal dynamics can help to design vaccines and monitor changes in viral transmission patterns. Brazil has one of...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tiago Gräf, Gonzalo Bello, Paula Andrade, Ighor Arantes, João Marcos Pereira, Alexandre Bonfim Pinheiro da Silva, Rafael V. Veiga, Diana Mariani, Lídia Theodoro Boullosa, Mônica B. Arruda, José Carlos Couto Fernandez, Ann M. Dennis, David A. Rasmussen, Amilcar Tanuri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0bbeb7a1ab0843b68c4c791acd43bcb5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0bbeb7a1ab0843b68c4c791acd43bcb5
record_format	dspace
spelling	oai:doaj.org-article:0bbeb7a1ab0843b68c4c791acd43bcb52021-12-02T17:06:08ZHIV-1 molecular diversity in Brazil unveiled by 10 years of sampling by the national genotyping network10.1038/s41598-021-94542-52045-2322https://doaj.org/article/0bbeb7a1ab0843b68c4c791acd43bcb52021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94542-5https://doaj.org/toc/2045-2322Abstract HIV-1 has diversified into several subtypes and recombinant forms that are heterogeneously spread around the world. Understanding the distribution of viral variants and their temporal dynamics can help to design vaccines and monitor changes in viral transmission patterns. Brazil has one of the largest HIV-1 epidemics in the western-world and the molecular features of the virus circulating in the country are still not completely known. Over 50,000 partial HIV-1 genomes sampled between 2008 and 2017 by the Brazilian genotyping network (RENAGENO) were analyzed. Sequences were filtered by quality, duplicate sequences per patient were removed and subtyping was performed with online tools and molecular phylogeny. Association between patients’ demographic data and subtypes were performed by calculating the relative risk in a multinomial analysis and trends in subtype prevalence were tested by Pearson correlation. HIV-1B was found to be the most prevalent subtype throughout the country except in the south, where HIV-1C prevails. An increasing trend in the proportion of HIV-1C and F1 was observed in several regions of the country, while HIV-1B tended to decrease. Men and highly educated individuals were more frequently infected by HIV-1B and non-B variants were more prevalent among women with lower education. Our results suggest that socio-demographic factors partially segregate HIV-1 diversity in Brazil while shaping viral transmission networks. Historical events could explain a preferential circulation of HIV-1B among men who have sex with men (MSM) and non-B variants among heterosexual individuals. In view of an increasing male/female ratio of AIDS cases in Brazil in the last 10–15 years, the decrease of HIV-1B prevalence is surprising and suggests a greater penetrance of non-B subtypes in MSM transmission chains.Tiago GräfGonzalo BelloPaula AndradeIghor ArantesJoão Marcos PereiraAlexandre Bonfim Pinheiro da SilvaRafael V. VeigaDiana MarianiLídia Theodoro BoullosaMônica B. ArrudaJosé Carlos Couto FernandezAnn M. DennisDavid A. RasmussenAmilcar TanuriNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tiago Gräf Gonzalo Bello Paula Andrade Ighor Arantes João Marcos Pereira Alexandre Bonfim Pinheiro da Silva Rafael V. Veiga Diana Mariani Lídia Theodoro Boullosa Mônica B. Arruda José Carlos Couto Fernandez Ann M. Dennis David A. Rasmussen Amilcar Tanuri HIV-1 molecular diversity in Brazil unveiled by 10 years of sampling by the national genotyping network
description	Abstract HIV-1 has diversified into several subtypes and recombinant forms that are heterogeneously spread around the world. Understanding the distribution of viral variants and their temporal dynamics can help to design vaccines and monitor changes in viral transmission patterns. Brazil has one of the largest HIV-1 epidemics in the western-world and the molecular features of the virus circulating in the country are still not completely known. Over 50,000 partial HIV-1 genomes sampled between 2008 and 2017 by the Brazilian genotyping network (RENAGENO) were analyzed. Sequences were filtered by quality, duplicate sequences per patient were removed and subtyping was performed with online tools and molecular phylogeny. Association between patients’ demographic data and subtypes were performed by calculating the relative risk in a multinomial analysis and trends in subtype prevalence were tested by Pearson correlation. HIV-1B was found to be the most prevalent subtype throughout the country except in the south, where HIV-1C prevails. An increasing trend in the proportion of HIV-1C and F1 was observed in several regions of the country, while HIV-1B tended to decrease. Men and highly educated individuals were more frequently infected by HIV-1B and non-B variants were more prevalent among women with lower education. Our results suggest that socio-demographic factors partially segregate HIV-1 diversity in Brazil while shaping viral transmission networks. Historical events could explain a preferential circulation of HIV-1B among men who have sex with men (MSM) and non-B variants among heterosexual individuals. In view of an increasing male/female ratio of AIDS cases in Brazil in the last 10–15 years, the decrease of HIV-1B prevalence is surprising and suggests a greater penetrance of non-B subtypes in MSM transmission chains.
format	article
author	Tiago Gräf Gonzalo Bello Paula Andrade Ighor Arantes João Marcos Pereira Alexandre Bonfim Pinheiro da Silva Rafael V. Veiga Diana Mariani Lídia Theodoro Boullosa Mônica B. Arruda José Carlos Couto Fernandez Ann M. Dennis David A. Rasmussen Amilcar Tanuri
author_facet	Tiago Gräf Gonzalo Bello Paula Andrade Ighor Arantes João Marcos Pereira Alexandre Bonfim Pinheiro da Silva Rafael V. Veiga Diana Mariani Lídia Theodoro Boullosa Mônica B. Arruda José Carlos Couto Fernandez Ann M. Dennis David A. Rasmussen Amilcar Tanuri
author_sort	Tiago Gräf
title	HIV-1 molecular diversity in Brazil unveiled by 10 years of sampling by the national genotyping network
title_short	HIV-1 molecular diversity in Brazil unveiled by 10 years of sampling by the national genotyping network
title_full	HIV-1 molecular diversity in Brazil unveiled by 10 years of sampling by the national genotyping network
title_fullStr	HIV-1 molecular diversity in Brazil unveiled by 10 years of sampling by the national genotyping network
title_full_unstemmed	HIV-1 molecular diversity in Brazil unveiled by 10 years of sampling by the national genotyping network
title_sort	hiv-1 molecular diversity in brazil unveiled by 10 years of sampling by the national genotyping network
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0bbeb7a1ab0843b68c4c791acd43bcb5
work_keys_str_mv	AT tiagograf hiv1moleculardiversityinbrazilunveiledby10yearsofsamplingbythenationalgenotypingnetwork AT gonzalobello hiv1moleculardiversityinbrazilunveiledby10yearsofsamplingbythenationalgenotypingnetwork AT paulaandrade hiv1moleculardiversityinbrazilunveiledby10yearsofsamplingbythenationalgenotypingnetwork AT ighorarantes hiv1moleculardiversityinbrazilunveiledby10yearsofsamplingbythenationalgenotypingnetwork AT joaomarcospereira hiv1moleculardiversityinbrazilunveiledby10yearsofsamplingbythenationalgenotypingnetwork AT alexandrebonfimpinheirodasilva hiv1moleculardiversityinbrazilunveiledby10yearsofsamplingbythenationalgenotypingnetwork AT rafaelvveiga hiv1moleculardiversityinbrazilunveiledby10yearsofsamplingbythenationalgenotypingnetwork AT dianamariani hiv1moleculardiversityinbrazilunveiledby10yearsofsamplingbythenationalgenotypingnetwork AT lidiatheodoroboullosa hiv1moleculardiversityinbrazilunveiledby10yearsofsamplingbythenationalgenotypingnetwork AT monicabarruda hiv1moleculardiversityinbrazilunveiledby10yearsofsamplingbythenationalgenotypingnetwork AT josecarloscoutofernandez hiv1moleculardiversityinbrazilunveiledby10yearsofsamplingbythenationalgenotypingnetwork AT annmdennis hiv1moleculardiversityinbrazilunveiledby10yearsofsamplingbythenationalgenotypingnetwork AT davidarasmussen hiv1moleculardiversityinbrazilunveiledby10yearsofsamplingbythenationalgenotypingnetwork AT amilcartanuri hiv1moleculardiversityinbrazilunveiledby10yearsofsamplingbythenationalgenotypingnetwork
_version_	1718381713365663744

HIV-1 molecular diversity in Brazil unveiled by 10 years of sampling by the national genotyping network

Ejemplares similares