A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours

S.Typhimurium can grow selectively on tumours and decreases the cellular levels of the multidrug resistance transporter Pgp. Here, the authors reveal the SipA-dependent mechanism of Pgp down-regulation and produce a SipA-based gold nanoparticle that increases sensitivity to the anticancer drug doxor...

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Autores principales:	Regino Mercado-Lubo, Yuanwei Zhang, Liang Zhao, Kyle Rossi, Xiang Wu, Yekui Zou, Antonio Castillo, Jack Leonard, Rita Bortell, Dale L. Greiner, Leonard D. Shultz, Gang Han, Beth A. McCormick
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0bc494bc80654602a8dff966f96a968c
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spelling	oai:doaj.org-article:0bc494bc80654602a8dff966f96a968c2021-12-02T15:35:00ZA Salmonella nanoparticle mimic overcomes multidrug resistance in tumours10.1038/ncomms122252041-1723https://doaj.org/article/0bc494bc80654602a8dff966f96a968c2016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12225https://doaj.org/toc/2041-1723S.Typhimurium can grow selectively on tumours and decreases the cellular levels of the multidrug resistance transporter Pgp. Here, the authors reveal the SipA-dependent mechanism of Pgp down-regulation and produce a SipA-based gold nanoparticle that increases sensitivity to the anticancer drug doxorubicin.Regino Mercado-LuboYuanwei ZhangLiang ZhaoKyle RossiXiang WuYekui ZouAntonio CastilloJack LeonardRita BortellDale L. GreinerLeonard D. ShultzGang HanBeth A. McCormickNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Regino Mercado-Lubo Yuanwei Zhang Liang Zhao Kyle Rossi Xiang Wu Yekui Zou Antonio Castillo Jack Leonard Rita Bortell Dale L. Greiner Leonard D. Shultz Gang Han Beth A. McCormick A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours
description	S.Typhimurium can grow selectively on tumours and decreases the cellular levels of the multidrug resistance transporter Pgp. Here, the authors reveal the SipA-dependent mechanism of Pgp down-regulation and produce a SipA-based gold nanoparticle that increases sensitivity to the anticancer drug doxorubicin.
format	article
author	Regino Mercado-Lubo Yuanwei Zhang Liang Zhao Kyle Rossi Xiang Wu Yekui Zou Antonio Castillo Jack Leonard Rita Bortell Dale L. Greiner Leonard D. Shultz Gang Han Beth A. McCormick
author_facet	Regino Mercado-Lubo Yuanwei Zhang Liang Zhao Kyle Rossi Xiang Wu Yekui Zou Antonio Castillo Jack Leonard Rita Bortell Dale L. Greiner Leonard D. Shultz Gang Han Beth A. McCormick
author_sort	Regino Mercado-Lubo
title	A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours
title_short	A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours
title_full	A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours
title_fullStr	A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours
title_full_unstemmed	A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours
title_sort	salmonella nanoparticle mimic overcomes multidrug resistance in tumours
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/0bc494bc80654602a8dff966f96a968c
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A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours

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