Surveillance and vaccine effectiveness of an influenza epidemic predominated by vaccine-mismatched influenza B/Yamagata-lineage viruses in Taiwan, 2011-12 season.

<h4>Introduction</h4>The 2011-12 trivalent influenza vaccine contains a strain of influenza B/Victoria-lineage viruses. Despite free provision of influenza vaccine among target populations, an epidemic predominated by influenza B/Yamagata-lineage viruses occurred during the 2011-12 seaso...

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Autores principales:	Yi-Chun Lo, Jen-Hsiang Chuang, Hung-Wei Kuo, Wan-Ting Huang, Yu-Fen Hsu, Ming-Tsan Liu, Chang-Hsun Chen, Hui-Hsun Huang, Chi-Hsi Chang, Jih-Haw Chou, Feng-Yee Chang, Tzou-Yien Lin, Wen-Ta Chiu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0bc7a2840d5f4faeaac3811ddb232bef
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spelling	oai:doaj.org-article:0bc7a2840d5f4faeaac3811ddb232bef2021-11-18T07:54:50ZSurveillance and vaccine effectiveness of an influenza epidemic predominated by vaccine-mismatched influenza B/Yamagata-lineage viruses in Taiwan, 2011-12 season.1932-620310.1371/journal.pone.0058222https://doaj.org/article/0bc7a2840d5f4faeaac3811ddb232bef2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23472161/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Introduction</h4>The 2011-12 trivalent influenza vaccine contains a strain of influenza B/Victoria-lineage viruses. Despite free provision of influenza vaccine among target populations, an epidemic predominated by influenza B/Yamagata-lineage viruses occurred during the 2011-12 season in Taiwan. We characterized this vaccine-mismatched epidemic and estimated influenza vaccine effectiveness (VE).<h4>Methods</h4>Influenza activity was monitored through sentinel viral surveillance, emergency department (ED) and outpatient influenza-like illness (ILI) syndromic surveillance, and case-based surveillance of influenza with complications and deaths. VE against laboratory-confirmed influenza was evaluated through a case-control study on ILI patients enrolled into sentinel viral surveillance. Logistic regression was used to estimate VE adjusted for confounding factors.<h4>Results</h4>During July 2011-June 2012, influenza B accounted for 2,382 (72.5%) of 3,285 influenza-positive respiratory specimens. Of 329 influenza B viral isolates with antigen characterization, 287 (87.2%) were B/Yamagata-lineage viruses. Proportions of ED and outpatient visits being ILI-related increased from November 2011 to January 2012. Of 1,704 confirmed cases of influenza with complications, including 154 (9.0%) deaths, influenza B accounted for 1,034 (60.7%) of the confirmed cases and 103 (66.9%) of the deaths. Reporting rates of confirmed influenza with complications and deaths were 73.5 and 6.6 per 1,000,000, respectively, highest among those aged ≥65 years, 50-64 years, 3-6 years, and 0-2 years. Adjusted VE was -31% (95% CI: -80, 4) against all influenza, 54% (95% CI: 3, 78) against influenza A, and -66% (95% CI: -132, -18) against influenza B.<h4>Conclusions</h4>This influenza epidemic in Taiwan was predominated by B/Yamagata-lineage viruses unprotected by the 2011-12 trivalent vaccine. The morbidity and mortality of this vaccine-mismatched epidemic warrants careful consideration of introducing a quadrivalent influenza vaccine that includes strains of both B lineages.Yi-Chun LoJen-Hsiang ChuangHung-Wei KuoWan-Ting HuangYu-Fen HsuMing-Tsan LiuChang-Hsun ChenHui-Hsun HuangChi-Hsi ChangJih-Haw ChouFeng-Yee ChangTzou-Yien LinWen-Ta ChiuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e58222 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yi-Chun Lo Jen-Hsiang Chuang Hung-Wei Kuo Wan-Ting Huang Yu-Fen Hsu Ming-Tsan Liu Chang-Hsun Chen Hui-Hsun Huang Chi-Hsi Chang Jih-Haw Chou Feng-Yee Chang Tzou-Yien Lin Wen-Ta Chiu Surveillance and vaccine effectiveness of an influenza epidemic predominated by vaccine-mismatched influenza B/Yamagata-lineage viruses in Taiwan, 2011-12 season.
description	<h4>Introduction</h4>The 2011-12 trivalent influenza vaccine contains a strain of influenza B/Victoria-lineage viruses. Despite free provision of influenza vaccine among target populations, an epidemic predominated by influenza B/Yamagata-lineage viruses occurred during the 2011-12 season in Taiwan. We characterized this vaccine-mismatched epidemic and estimated influenza vaccine effectiveness (VE).<h4>Methods</h4>Influenza activity was monitored through sentinel viral surveillance, emergency department (ED) and outpatient influenza-like illness (ILI) syndromic surveillance, and case-based surveillance of influenza with complications and deaths. VE against laboratory-confirmed influenza was evaluated through a case-control study on ILI patients enrolled into sentinel viral surveillance. Logistic regression was used to estimate VE adjusted for confounding factors.<h4>Results</h4>During July 2011-June 2012, influenza B accounted for 2,382 (72.5%) of 3,285 influenza-positive respiratory specimens. Of 329 influenza B viral isolates with antigen characterization, 287 (87.2%) were B/Yamagata-lineage viruses. Proportions of ED and outpatient visits being ILI-related increased from November 2011 to January 2012. Of 1,704 confirmed cases of influenza with complications, including 154 (9.0%) deaths, influenza B accounted for 1,034 (60.7%) of the confirmed cases and 103 (66.9%) of the deaths. Reporting rates of confirmed influenza with complications and deaths were 73.5 and 6.6 per 1,000,000, respectively, highest among those aged ≥65 years, 50-64 years, 3-6 years, and 0-2 years. Adjusted VE was -31% (95% CI: -80, 4) against all influenza, 54% (95% CI: 3, 78) against influenza A, and -66% (95% CI: -132, -18) against influenza B.<h4>Conclusions</h4>This influenza epidemic in Taiwan was predominated by B/Yamagata-lineage viruses unprotected by the 2011-12 trivalent vaccine. The morbidity and mortality of this vaccine-mismatched epidemic warrants careful consideration of introducing a quadrivalent influenza vaccine that includes strains of both B lineages.
format	article
author	Yi-Chun Lo Jen-Hsiang Chuang Hung-Wei Kuo Wan-Ting Huang Yu-Fen Hsu Ming-Tsan Liu Chang-Hsun Chen Hui-Hsun Huang Chi-Hsi Chang Jih-Haw Chou Feng-Yee Chang Tzou-Yien Lin Wen-Ta Chiu
author_facet	Yi-Chun Lo Jen-Hsiang Chuang Hung-Wei Kuo Wan-Ting Huang Yu-Fen Hsu Ming-Tsan Liu Chang-Hsun Chen Hui-Hsun Huang Chi-Hsi Chang Jih-Haw Chou Feng-Yee Chang Tzou-Yien Lin Wen-Ta Chiu
author_sort	Yi-Chun Lo
title	Surveillance and vaccine effectiveness of an influenza epidemic predominated by vaccine-mismatched influenza B/Yamagata-lineage viruses in Taiwan, 2011-12 season.
title_short	Surveillance and vaccine effectiveness of an influenza epidemic predominated by vaccine-mismatched influenza B/Yamagata-lineage viruses in Taiwan, 2011-12 season.
title_full	Surveillance and vaccine effectiveness of an influenza epidemic predominated by vaccine-mismatched influenza B/Yamagata-lineage viruses in Taiwan, 2011-12 season.
title_fullStr	Surveillance and vaccine effectiveness of an influenza epidemic predominated by vaccine-mismatched influenza B/Yamagata-lineage viruses in Taiwan, 2011-12 season.
title_full_unstemmed	Surveillance and vaccine effectiveness of an influenza epidemic predominated by vaccine-mismatched influenza B/Yamagata-lineage viruses in Taiwan, 2011-12 season.
title_sort	surveillance and vaccine effectiveness of an influenza epidemic predominated by vaccine-mismatched influenza b/yamagata-lineage viruses in taiwan, 2011-12 season.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/0bc7a2840d5f4faeaac3811ddb232bef
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Surveillance and vaccine effectiveness of an influenza epidemic predominated by vaccine-mismatched influenza B/Yamagata-lineage viruses in Taiwan, 2011-12 season.

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