Time-Restricted Feeding Restores Obesity-Induced Alteration in Adipose Tissue Immune Cell Phenotype

Studies suggest that time-restricted feeding (TRF) may prevent obesity and its commodities. At present, little is known about how TRF impacts immune cells, and whether such an effect is linked to altered metabolic parameters under condition of a high-fat diet (HFD)-induced obesity. To address these...

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Autores principales:	Youngyoon Lee, Yelim Kim, Minam Lee, Dayong Wu, Munkyong Pae
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	insulin resistance macrophages obesity T cells time-restricted feeding Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/0bc805964c9347f68428f4857645c270
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spelling	oai:doaj.org-article:0bc805964c9347f68428f4857645c2702021-11-25T18:33:58ZTime-Restricted Feeding Restores Obesity-Induced Alteration in Adipose Tissue Immune Cell Phenotype10.3390/nu131137802072-6643https://doaj.org/article/0bc805964c9347f68428f4857645c2702021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3780https://doaj.org/toc/2072-6643Studies suggest that time-restricted feeding (TRF) may prevent obesity and its commodities. At present, little is known about how TRF impacts immune cells, and whether such an effect is linked to altered metabolic parameters under condition of a high-fat diet (HFD)-induced obesity. To address these issues, we conducted a study in which we determined whether TRF has therapeutic efficacy against weight gain, adiposity, as well as associated immune cell disturbance found in obese mice. Six-week-old male C57BL/6 mice were fed a low-fat diet (LFD) or HFD ad libitum for six weeks, after which time a subgroup of HFD mice was switched to the 10 h TRF paradigm (HFD-TRF) for additional eight weeks. We found that TRF intervention reduced HFD-induced weight gain. Even with comparable fat mass and mean adipocyte area, the HFD-TRF group had lower mRNA levels of proinflammatory cytokine <i>Tnfα</i> and chemokine <i>Ccl8</i>, along with reduced numbers of adipose tissue macrophages (ATM), CD11c<sup>+</sup> ATM, and CD8<sup>+</sup> T cell compared to the HFD group, while maintaining CD8<sup>+</sup> to CD4<sup>+</sup> ratio at levels similar to those in the LFD group. Furthermore, TRF intervention was effective in improving glucose tolerance and reducing HOMA-IR. Taken together, our findings suggest that TRF restores the obesity-induced alteration in immune cell composition, and this effect may in part contribute to health benefits (including insulin sensitivity) of practicing TRF.Youngyoon LeeYelim KimMinam LeeDayong WuMunkyong PaeMDPI AGarticleinsulin resistancemacrophagesobesityT cellstime-restricted feedingNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3780, p 3780 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	insulin resistance macrophages obesity T cells time-restricted feeding Nutrition. Foods and food supply TX341-641
spellingShingle	insulin resistance macrophages obesity T cells time-restricted feeding Nutrition. Foods and food supply TX341-641 Youngyoon Lee Yelim Kim Minam Lee Dayong Wu Munkyong Pae Time-Restricted Feeding Restores Obesity-Induced Alteration in Adipose Tissue Immune Cell Phenotype
description	Studies suggest that time-restricted feeding (TRF) may prevent obesity and its commodities. At present, little is known about how TRF impacts immune cells, and whether such an effect is linked to altered metabolic parameters under condition of a high-fat diet (HFD)-induced obesity. To address these issues, we conducted a study in which we determined whether TRF has therapeutic efficacy against weight gain, adiposity, as well as associated immune cell disturbance found in obese mice. Six-week-old male C57BL/6 mice were fed a low-fat diet (LFD) or HFD ad libitum for six weeks, after which time a subgroup of HFD mice was switched to the 10 h TRF paradigm (HFD-TRF) for additional eight weeks. We found that TRF intervention reduced HFD-induced weight gain. Even with comparable fat mass and mean adipocyte area, the HFD-TRF group had lower mRNA levels of proinflammatory cytokine <i>Tnfα</i> and chemokine <i>Ccl8</i>, along with reduced numbers of adipose tissue macrophages (ATM), CD11c<sup>+</sup> ATM, and CD8<sup>+</sup> T cell compared to the HFD group, while maintaining CD8<sup>+</sup> to CD4<sup>+</sup> ratio at levels similar to those in the LFD group. Furthermore, TRF intervention was effective in improving glucose tolerance and reducing HOMA-IR. Taken together, our findings suggest that TRF restores the obesity-induced alteration in immune cell composition, and this effect may in part contribute to health benefits (including insulin sensitivity) of practicing TRF.
format	article
author	Youngyoon Lee Yelim Kim Minam Lee Dayong Wu Munkyong Pae
author_facet	Youngyoon Lee Yelim Kim Minam Lee Dayong Wu Munkyong Pae
author_sort	Youngyoon Lee
title	Time-Restricted Feeding Restores Obesity-Induced Alteration in Adipose Tissue Immune Cell Phenotype
title_short	Time-Restricted Feeding Restores Obesity-Induced Alteration in Adipose Tissue Immune Cell Phenotype
title_full	Time-Restricted Feeding Restores Obesity-Induced Alteration in Adipose Tissue Immune Cell Phenotype
title_fullStr	Time-Restricted Feeding Restores Obesity-Induced Alteration in Adipose Tissue Immune Cell Phenotype
title_full_unstemmed	Time-Restricted Feeding Restores Obesity-Induced Alteration in Adipose Tissue Immune Cell Phenotype
title_sort	time-restricted feeding restores obesity-induced alteration in adipose tissue immune cell phenotype
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0bc805964c9347f68428f4857645c270
work_keys_str_mv	AT youngyoonlee timerestrictedfeedingrestoresobesityinducedalterationinadiposetissueimmunecellphenotype AT yelimkim timerestrictedfeedingrestoresobesityinducedalterationinadiposetissueimmunecellphenotype AT minamlee timerestrictedfeedingrestoresobesityinducedalterationinadiposetissueimmunecellphenotype AT dayongwu timerestrictedfeedingrestoresobesityinducedalterationinadiposetissueimmunecellphenotype AT munkyongpae timerestrictedfeedingrestoresobesityinducedalterationinadiposetissueimmunecellphenotype
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Time-Restricted Feeding Restores Obesity-Induced Alteration in Adipose Tissue Immune Cell Phenotype

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