Pulmonary Artery Stiffness by Cardiac Magnetic Resonance Imaging Predicts Major Adverse Cardiovascular Events in patients with Chronic Obstructive Pulmonary Disease

Abstract In this prospective pilot study, we aimed to evaluate the ability of cardiac magnetic resonance imaging (CMR) parameters of right ventricular function and pulmonary artery stiffness to identify pulmonary hypertension (PH), predict major adverse cardiovascular events (MACEs) in patients with...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lucia Agoston-Coldea, Silvia Lupu, Teodora Mocan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	PA Stiffness Major Adverse Cardiovascular Events (MACEs) Chronic Obstructive Pulmonary Disease Right Heart Catheterization (RHC) Pulse Wave Velocity (PWV) Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0bc9f92421864824a1adc105790508fb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0bc9f92421864824a1adc105790508fb
record_format	dspace
spelling	oai:doaj.org-article:0bc9f92421864824a1adc105790508fb2021-12-02T15:08:18ZPulmonary Artery Stiffness by Cardiac Magnetic Resonance Imaging Predicts Major Adverse Cardiovascular Events in patients with Chronic Obstructive Pulmonary Disease10.1038/s41598-018-32784-62045-2322https://doaj.org/article/0bc9f92421864824a1adc105790508fb2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-32784-6https://doaj.org/toc/2045-2322Abstract In this prospective pilot study, we aimed to evaluate the ability of cardiac magnetic resonance imaging (CMR) parameters of right ventricular function and pulmonary artery stiffness to identify pulmonary hypertension (PH), predict major adverse cardiovascular events (MACEs) in patients with secondary PH due to chronic obstructive pulmonary disease (COPD), and to estimate a prospective sample size necessary for a reliable power of the study. Thirty consecutive patients with COPD and suspected secondary PH were assessed by clinical examination, the six minute walk test, echocardiography, right heart catheterization and CMR, and followed–up for a mean period of 16 months to identify MACEs (cardiac death, ventricular tachyarrhythmia, and heart failure). Among CMR parameters of pulmonary artery stiffness, pulse wave velocity (PWV) yielded the best sensitivity (93.5%) and specificity (92.8%) for identifying PH, as diagnosed by cardiac catheterization. Moreover, PWV proved to be a valuable predictor of MACEs (HR = 4.75, 95% CI 1.00 to 22.59, p = 0.03). In conclusion, PWV by phase-contrast CMR can accurately identify PH in patients with COPD and may help stratify prognosis.Lucia Agoston-ColdeaSilvia LupuTeodora MocanNature PortfolioarticlePA StiffnessMajor Adverse Cardiovascular Events (MACEs)Chronic Obstructive Pulmonary DiseaseRight Heart Catheterization (RHC)Pulse Wave Velocity (PWV)MedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	PA Stiffness Major Adverse Cardiovascular Events (MACEs) Chronic Obstructive Pulmonary Disease Right Heart Catheterization (RHC) Pulse Wave Velocity (PWV) Medicine R Science Q
spellingShingle	PA Stiffness Major Adverse Cardiovascular Events (MACEs) Chronic Obstructive Pulmonary Disease Right Heart Catheterization (RHC) Pulse Wave Velocity (PWV) Medicine R Science Q Lucia Agoston-Coldea Silvia Lupu Teodora Mocan Pulmonary Artery Stiffness by Cardiac Magnetic Resonance Imaging Predicts Major Adverse Cardiovascular Events in patients with Chronic Obstructive Pulmonary Disease
description	Abstract In this prospective pilot study, we aimed to evaluate the ability of cardiac magnetic resonance imaging (CMR) parameters of right ventricular function and pulmonary artery stiffness to identify pulmonary hypertension (PH), predict major adverse cardiovascular events (MACEs) in patients with secondary PH due to chronic obstructive pulmonary disease (COPD), and to estimate a prospective sample size necessary for a reliable power of the study. Thirty consecutive patients with COPD and suspected secondary PH were assessed by clinical examination, the six minute walk test, echocardiography, right heart catheterization and CMR, and followed–up for a mean period of 16 months to identify MACEs (cardiac death, ventricular tachyarrhythmia, and heart failure). Among CMR parameters of pulmonary artery stiffness, pulse wave velocity (PWV) yielded the best sensitivity (93.5%) and specificity (92.8%) for identifying PH, as diagnosed by cardiac catheterization. Moreover, PWV proved to be a valuable predictor of MACEs (HR = 4.75, 95% CI 1.00 to 22.59, p = 0.03). In conclusion, PWV by phase-contrast CMR can accurately identify PH in patients with COPD and may help stratify prognosis.
format	article
author	Lucia Agoston-Coldea Silvia Lupu Teodora Mocan
author_facet	Lucia Agoston-Coldea Silvia Lupu Teodora Mocan
author_sort	Lucia Agoston-Coldea
title	Pulmonary Artery Stiffness by Cardiac Magnetic Resonance Imaging Predicts Major Adverse Cardiovascular Events in patients with Chronic Obstructive Pulmonary Disease
title_short	Pulmonary Artery Stiffness by Cardiac Magnetic Resonance Imaging Predicts Major Adverse Cardiovascular Events in patients with Chronic Obstructive Pulmonary Disease
title_full	Pulmonary Artery Stiffness by Cardiac Magnetic Resonance Imaging Predicts Major Adverse Cardiovascular Events in patients with Chronic Obstructive Pulmonary Disease
title_fullStr	Pulmonary Artery Stiffness by Cardiac Magnetic Resonance Imaging Predicts Major Adverse Cardiovascular Events in patients with Chronic Obstructive Pulmonary Disease
title_full_unstemmed	Pulmonary Artery Stiffness by Cardiac Magnetic Resonance Imaging Predicts Major Adverse Cardiovascular Events in patients with Chronic Obstructive Pulmonary Disease
title_sort	pulmonary artery stiffness by cardiac magnetic resonance imaging predicts major adverse cardiovascular events in patients with chronic obstructive pulmonary disease
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0bc9f92421864824a1adc105790508fb
work_keys_str_mv	AT luciaagostoncoldea pulmonaryarterystiffnessbycardiacmagneticresonanceimagingpredictsmajoradversecardiovasculareventsinpatientswithchronicobstructivepulmonarydisease AT silvialupu pulmonaryarterystiffnessbycardiacmagneticresonanceimagingpredictsmajoradversecardiovasculareventsinpatientswithchronicobstructivepulmonarydisease AT teodoramocan pulmonaryarterystiffnessbycardiacmagneticresonanceimagingpredictsmajoradversecardiovasculareventsinpatientswithchronicobstructivepulmonarydisease
_version_	1718388168168833024

Pulmonary Artery Stiffness by Cardiac Magnetic Resonance Imaging Predicts Major Adverse Cardiovascular Events in patients with Chronic Obstructive Pulmonary Disease

Ejemplares similares