Autocatalytic Time-Dependent Evolution of Metastable Two-Component Supramolecular Assemblies to Self-Sorted or Coassembled State

Abstract Despite substantial effort devoted in the history of supramolecular chemistry, synthetic supramolecular systems still lag behind biomolecular systems in terms of complexity and functionality. This is because biomolecular systems function in a multicomponent molecular network under out-of-eq...

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Autores principales:	Tomoya Fukui, Masayuki Takeuchi, Kazunori Sugiyasu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0bca104f74d94d42a8c3ad469b9f6ab7
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spelling	oai:doaj.org-article:0bca104f74d94d42a8c3ad469b9f6ab72021-12-02T15:04:53ZAutocatalytic Time-Dependent Evolution of Metastable Two-Component Supramolecular Assemblies to Self-Sorted or Coassembled State10.1038/s41598-017-02524-32045-2322https://doaj.org/article/0bca104f74d94d42a8c3ad469b9f6ab72017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02524-3https://doaj.org/toc/2045-2322Abstract Despite substantial effort devoted in the history of supramolecular chemistry, synthetic supramolecular systems still lag behind biomolecular systems in terms of complexity and functionality. This is because biomolecular systems function in a multicomponent molecular network under out-of-equilibrium conditions. Here we report two-component supramolecular assemblies that are metastable and thus show time-dependent evolution. We found that the systems undergo either self-sorting or coassembly in time depending on the combination of components. Interestingly, this outcome, which had been previously achievable only under specific conditions, emerged from the two-component systems as a result of synergistic or reciprocal interplay between the coupled equilibria. We believe that this study sheds light on the similarity between synthetic and biomolecular systems and promotes better understanding of their intricate kinetic behaviors.Tomoya FukuiMasayuki TakeuchiKazunori SugiyasuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tomoya Fukui Masayuki Takeuchi Kazunori Sugiyasu Autocatalytic Time-Dependent Evolution of Metastable Two-Component Supramolecular Assemblies to Self-Sorted or Coassembled State
description	Abstract Despite substantial effort devoted in the history of supramolecular chemistry, synthetic supramolecular systems still lag behind biomolecular systems in terms of complexity and functionality. This is because biomolecular systems function in a multicomponent molecular network under out-of-equilibrium conditions. Here we report two-component supramolecular assemblies that are metastable and thus show time-dependent evolution. We found that the systems undergo either self-sorting or coassembly in time depending on the combination of components. Interestingly, this outcome, which had been previously achievable only under specific conditions, emerged from the two-component systems as a result of synergistic or reciprocal interplay between the coupled equilibria. We believe that this study sheds light on the similarity between synthetic and biomolecular systems and promotes better understanding of their intricate kinetic behaviors.
format	article
author	Tomoya Fukui Masayuki Takeuchi Kazunori Sugiyasu
author_facet	Tomoya Fukui Masayuki Takeuchi Kazunori Sugiyasu
author_sort	Tomoya Fukui
title	Autocatalytic Time-Dependent Evolution of Metastable Two-Component Supramolecular Assemblies to Self-Sorted or Coassembled State
title_short	Autocatalytic Time-Dependent Evolution of Metastable Two-Component Supramolecular Assemblies to Self-Sorted or Coassembled State
title_full	Autocatalytic Time-Dependent Evolution of Metastable Two-Component Supramolecular Assemblies to Self-Sorted or Coassembled State
title_fullStr	Autocatalytic Time-Dependent Evolution of Metastable Two-Component Supramolecular Assemblies to Self-Sorted or Coassembled State
title_full_unstemmed	Autocatalytic Time-Dependent Evolution of Metastable Two-Component Supramolecular Assemblies to Self-Sorted or Coassembled State
title_sort	autocatalytic time-dependent evolution of metastable two-component supramolecular assemblies to self-sorted or coassembled state
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0bca104f74d94d42a8c3ad469b9f6ab7
work_keys_str_mv	AT tomoyafukui autocatalytictimedependentevolutionofmetastabletwocomponentsupramolecularassembliestoselfsortedorcoassembledstate AT masayukitakeuchi autocatalytictimedependentevolutionofmetastabletwocomponentsupramolecularassembliestoselfsortedorcoassembledstate AT kazunorisugiyasu autocatalytictimedependentevolutionofmetastabletwocomponentsupramolecularassembliestoselfsortedorcoassembledstate
_version_	1718388997849350144

Autocatalytic Time-Dependent Evolution of Metastable Two-Component Supramolecular Assemblies to Self-Sorted or Coassembled State

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