Response and safety of whole‐brain radiotherapy plus temozolomide for patients with brain metastases of non‐small‐cell lung cancer: A meta‐analysis

Abstract Objective The aim of the present work was to investigate the response and safety of whole‐brain radiotherapy (WBRT) plus temozolomide (TMZ) for patients with brain metastases of non‐small‐cell lung cancer (NSCLC). Methods The electronic databases of Pubmed, EMbase, Cochrane, Wangfang, china...

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Autores principales:	Jianguo Han, Ming Qiu, Li Su, Chong Wu, Si Cheng, Zhijun Zhao, Danxia Li, Menghui Wang, Wei Tao, Shiwei Du
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	brain metastases meta‐analysis non‐small‐cell lung cancer temozolomide whole‐brain radiotherapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/0bd643f7339348b8bdf053692a1cb7e3
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spelling	oai:doaj.org-article:0bd643f7339348b8bdf053692a1cb7e32021-12-02T02:34:55ZResponse and safety of whole‐brain radiotherapy plus temozolomide for patients with brain metastases of non‐small‐cell lung cancer: A meta‐analysis1759-77141759-770610.1111/1759-7714.14183https://doaj.org/article/0bd643f7339348b8bdf053692a1cb7e32021-12-01T00:00:00Zhttps://doi.org/10.1111/1759-7714.14183https://doaj.org/toc/1759-7706https://doaj.org/toc/1759-7714Abstract Objective The aim of the present work was to investigate the response and safety of whole‐brain radiotherapy (WBRT) plus temozolomide (TMZ) for patients with brain metastases of non‐small‐cell lung cancer (NSCLC). Methods The electronic databases of Pubmed, EMbase, Cochrane, Wangfang, china national knowledge infrastructure (CNKI), and Google scholar were systematically searched to identify the prospective randomized trials relevant to WBRT plus TMZ for patients with brain metastases of NSCLC. The data associated with treatment response and toxicity were extracted from original included studies. The relative risk (RR) for treatment response and toxicity between WBRT+TMZ and WBRT alone was pooled by fixed or random effect model. Publication bias was investigated by Begg's funnel plot and Egger's line regression test. Results Twenty‐five clinical trials fulfilled the inclusion criteria and were included in the meta‐analysis. The pooled results showed WBRT+TMZ can significant improve the objective response rate (ORR) compared with WBRT alone (RR = 1.43, 95% confidence interval [CI] 1.32–1.55, p < 0.05) under a fixed effect model. WBRT+TMZ significantly increased the III–IV hematological toxicity compared to WBRT alone (RR = 1.66, 95% CI 1.12–2.54, p < 0.05) in the fixed effect model. Grade III–IV gastrointestinal toxicity was increased in WBRT+TMZ compared to WBRT alone (RR = 1.72, 95% CI 1.29–2.30, p < 0.05). Begg's funnel plot and Egger's line regression test indicated publication bias. Conclusion Based on the present work, WBRT+TMZ can improve the ORR for brain metastases of NSCLC, but the risk of treatment‐associated grade III/IV hematological toxicity and gastrointestinal toxicity were also increased compared to WBRT alone.Jianguo HanMing QiuLi SuChong WuSi ChengZhijun ZhaoDanxia LiMenghui WangWei TaoShiwei DuWileyarticlebrain metastasesmeta‐analysisnon‐small‐cell lung cancertemozolomidewhole‐brain radiotherapyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENThoracic Cancer, Vol 12, Iss 23, Pp 3177-3183 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	brain metastases meta‐analysis non‐small‐cell lung cancer temozolomide whole‐brain radiotherapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	brain metastases meta‐analysis non‐small‐cell lung cancer temozolomide whole‐brain radiotherapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Jianguo Han Ming Qiu Li Su Chong Wu Si Cheng Zhijun Zhao Danxia Li Menghui Wang Wei Tao Shiwei Du Response and safety of whole‐brain radiotherapy plus temozolomide for patients with brain metastases of non‐small‐cell lung cancer: A meta‐analysis
description	Abstract Objective The aim of the present work was to investigate the response and safety of whole‐brain radiotherapy (WBRT) plus temozolomide (TMZ) for patients with brain metastases of non‐small‐cell lung cancer (NSCLC). Methods The electronic databases of Pubmed, EMbase, Cochrane, Wangfang, china national knowledge infrastructure (CNKI), and Google scholar were systematically searched to identify the prospective randomized trials relevant to WBRT plus TMZ for patients with brain metastases of NSCLC. The data associated with treatment response and toxicity were extracted from original included studies. The relative risk (RR) for treatment response and toxicity between WBRT+TMZ and WBRT alone was pooled by fixed or random effect model. Publication bias was investigated by Begg's funnel plot and Egger's line regression test. Results Twenty‐five clinical trials fulfilled the inclusion criteria and were included in the meta‐analysis. The pooled results showed WBRT+TMZ can significant improve the objective response rate (ORR) compared with WBRT alone (RR = 1.43, 95% confidence interval [CI] 1.32–1.55, p < 0.05) under a fixed effect model. WBRT+TMZ significantly increased the III–IV hematological toxicity compared to WBRT alone (RR = 1.66, 95% CI 1.12–2.54, p < 0.05) in the fixed effect model. Grade III–IV gastrointestinal toxicity was increased in WBRT+TMZ compared to WBRT alone (RR = 1.72, 95% CI 1.29–2.30, p < 0.05). Begg's funnel plot and Egger's line regression test indicated publication bias. Conclusion Based on the present work, WBRT+TMZ can improve the ORR for brain metastases of NSCLC, but the risk of treatment‐associated grade III/IV hematological toxicity and gastrointestinal toxicity were also increased compared to WBRT alone.
format	article
author	Jianguo Han Ming Qiu Li Su Chong Wu Si Cheng Zhijun Zhao Danxia Li Menghui Wang Wei Tao Shiwei Du
author_facet	Jianguo Han Ming Qiu Li Su Chong Wu Si Cheng Zhijun Zhao Danxia Li Menghui Wang Wei Tao Shiwei Du
author_sort	Jianguo Han
title	Response and safety of whole‐brain radiotherapy plus temozolomide for patients with brain metastases of non‐small‐cell lung cancer: A meta‐analysis
title_short	Response and safety of whole‐brain radiotherapy plus temozolomide for patients with brain metastases of non‐small‐cell lung cancer: A meta‐analysis
title_full	Response and safety of whole‐brain radiotherapy plus temozolomide for patients with brain metastases of non‐small‐cell lung cancer: A meta‐analysis
title_fullStr	Response and safety of whole‐brain radiotherapy plus temozolomide for patients with brain metastases of non‐small‐cell lung cancer: A meta‐analysis
title_full_unstemmed	Response and safety of whole‐brain radiotherapy plus temozolomide for patients with brain metastases of non‐small‐cell lung cancer: A meta‐analysis
title_sort	response and safety of whole‐brain radiotherapy plus temozolomide for patients with brain metastases of non‐small‐cell lung cancer: a meta‐analysis
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/0bd643f7339348b8bdf053692a1cb7e3
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Response and safety of whole‐brain radiotherapy plus temozolomide for patients with brain metastases of non‐small‐cell lung cancer: A meta‐analysis

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