Nanoparticle-based Chemiluminescence for Chiral Discrimination of Thiol-Containing Amino Acids

Abstract The ability to recognize the molecular chirality of enantiomers is extremely important owing to their critical role in drug development and biochemistry. Convenient discrimination of enantiomers has remained a challenge due to lack of unsophisticated methods. In this work, we have reported...

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Autores principales:	Maryam Shahrajabian, Forough Ghasemi, M. Reza Hormozi-Nezhad
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Chiral Discrimination Thiol-containing Amino Acid Chiral Recognition Penicillamine (PA) Enantiomeric Excess Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0bd76de724974103954c44db14cae719
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spelling	oai:doaj.org-article:0bd76de724974103954c44db14cae7192021-12-02T15:08:15ZNanoparticle-based Chemiluminescence for Chiral Discrimination of Thiol-Containing Amino Acids10.1038/s41598-018-32416-z2045-2322https://doaj.org/article/0bd76de724974103954c44db14cae7192018-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-32416-zhttps://doaj.org/toc/2045-2322Abstract The ability to recognize the molecular chirality of enantiomers is extremely important owing to their critical role in drug development and biochemistry. Convenient discrimination of enantiomers has remained a challenge due to lack of unsophisticated methods. In this work, we have reported a simple strategy for chiral recognition of thiol-containing amino acids including penicillamine (PA), and cysteine (Cys). We have successfully designed a nanoparticle-based chemiluminescence (CL) system based on the reaction between cadmium telluride quantum dots (CdTe QDs) and the enantiomers. The different interactions of CdTe QDs with PA enantiomers or Cys enantiomers led to different CL intensities, resulting in the chiral recognition of these enantiomers. The developed method showed the ability for determination of enantiomeric excess of PA and Cys. It has also obtained an enantioselective concentration range from 1.15 to 9.2 mM for PA. To demonstrate the potential application of this method, the designed platform was applied for the quantification of PA in urine and tablet samples. For the first time, we presented a novel practical application of nanoparticle-based CL system for chiral discrimination.Maryam ShahrajabianForough GhasemiM. Reza Hormozi-NezhadNature PortfolioarticleChiral DiscriminationThiol-containing Amino AcidChiral RecognitionPenicillamine (PA)Enantiomeric ExcessMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chiral Discrimination Thiol-containing Amino Acid Chiral Recognition Penicillamine (PA) Enantiomeric Excess Medicine R Science Q
spellingShingle	Chiral Discrimination Thiol-containing Amino Acid Chiral Recognition Penicillamine (PA) Enantiomeric Excess Medicine R Science Q Maryam Shahrajabian Forough Ghasemi M. Reza Hormozi-Nezhad Nanoparticle-based Chemiluminescence for Chiral Discrimination of Thiol-Containing Amino Acids
description	Abstract The ability to recognize the molecular chirality of enantiomers is extremely important owing to their critical role in drug development and biochemistry. Convenient discrimination of enantiomers has remained a challenge due to lack of unsophisticated methods. In this work, we have reported a simple strategy for chiral recognition of thiol-containing amino acids including penicillamine (PA), and cysteine (Cys). We have successfully designed a nanoparticle-based chemiluminescence (CL) system based on the reaction between cadmium telluride quantum dots (CdTe QDs) and the enantiomers. The different interactions of CdTe QDs with PA enantiomers or Cys enantiomers led to different CL intensities, resulting in the chiral recognition of these enantiomers. The developed method showed the ability for determination of enantiomeric excess of PA and Cys. It has also obtained an enantioselective concentration range from 1.15 to 9.2 mM for PA. To demonstrate the potential application of this method, the designed platform was applied for the quantification of PA in urine and tablet samples. For the first time, we presented a novel practical application of nanoparticle-based CL system for chiral discrimination.
format	article
author	Maryam Shahrajabian Forough Ghasemi M. Reza Hormozi-Nezhad
author_facet	Maryam Shahrajabian Forough Ghasemi M. Reza Hormozi-Nezhad
author_sort	Maryam Shahrajabian
title	Nanoparticle-based Chemiluminescence for Chiral Discrimination of Thiol-Containing Amino Acids
title_short	Nanoparticle-based Chemiluminescence for Chiral Discrimination of Thiol-Containing Amino Acids
title_full	Nanoparticle-based Chemiluminescence for Chiral Discrimination of Thiol-Containing Amino Acids
title_fullStr	Nanoparticle-based Chemiluminescence for Chiral Discrimination of Thiol-Containing Amino Acids
title_full_unstemmed	Nanoparticle-based Chemiluminescence for Chiral Discrimination of Thiol-Containing Amino Acids
title_sort	nanoparticle-based chemiluminescence for chiral discrimination of thiol-containing amino acids
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0bd76de724974103954c44db14cae719
work_keys_str_mv	AT maryamshahrajabian nanoparticlebasedchemiluminescenceforchiraldiscriminationofthiolcontainingaminoacids AT foroughghasemi nanoparticlebasedchemiluminescenceforchiraldiscriminationofthiolcontainingaminoacids AT mrezahormozinezhad nanoparticlebasedchemiluminescenceforchiraldiscriminationofthiolcontainingaminoacids
_version_	1718388168394276864

Nanoparticle-based Chemiluminescence for Chiral Discrimination of Thiol-Containing Amino Acids

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