3-year follow-up of half-dose verteporfin photodynamic therapy for central serous chorioretinopathy with OCT-angiography detected choroidal neovascularization

Abstract To assess the 3-year outcome of half-dose verteporfin photodynamic therapy (PDT) in central serous chorioretinopathy (CSC) with optical coherence tomography angiography (OCT-A) detected choroidal neovascularization (CNV), we performed a retrospective, interventional study. Patients were div...

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Autores principales:	Yu-Chen Hu, Yi-Ling Chen, Yen-Chih Chen, San-Ni Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0bde7ba4bdb94ab8af65a9bf9ec81c75
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spelling	oai:doaj.org-article:0bde7ba4bdb94ab8af65a9bf9ec81c752021-12-02T16:05:54Z3-year follow-up of half-dose verteporfin photodynamic therapy for central serous chorioretinopathy with OCT-angiography detected choroidal neovascularization10.1038/s41598-021-92693-z2045-2322https://doaj.org/article/0bde7ba4bdb94ab8af65a9bf9ec81c752021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92693-zhttps://doaj.org/toc/2045-2322Abstract To assess the 3-year outcome of half-dose verteporfin photodynamic therapy (PDT) in central serous chorioretinopathy (CSC) with optical coherence tomography angiography (OCT-A) detected choroidal neovascularization (CNV), we performed a retrospective, interventional study. Patients were divided into 2 groups according to the fluorescein angiography: point source leakage in group 1 and diffuse oozing in group 2. Data were collected from patients including changes of best-corrected visual acuity (BCVA), size of CNV, central macular thickness (CMT), choroidal thickness (CT), reabsorption of subretinal fluid (SRF), sessions of half-dose PDT, and the number of intravitreal injections (IVI) of anti-vascular endothelial growth factor (anti-VEGF). There was a total of 34 eyes in 32 patients included. The mean sessions of half-dose PDT was 1.50 ± 0.75. The mean number of IVI of anti-VEGF was 1.38 ± 3.34. BCVA improved from 0.38 ± 0.33 to 0.20 ± 0.22 (p < 0.001). Mean CMT was significantly reduced along with reduced CT and increased size of CNV. SRF was totally reabsorbed in 31 eyes. Patients in group 1 had significant less sessions of PDT and better final BCVA. In conclusion, half-dose PDT treatment was effective for CSC with CNV. Patients with diffuse oozing in FA may fare less well with half-dose PDT.Yu-Chen HuYi-Ling ChenYen-Chih ChenSan-Ni ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yu-Chen Hu Yi-Ling Chen Yen-Chih Chen San-Ni Chen 3-year follow-up of half-dose verteporfin photodynamic therapy for central serous chorioretinopathy with OCT-angiography detected choroidal neovascularization
description	Abstract To assess the 3-year outcome of half-dose verteporfin photodynamic therapy (PDT) in central serous chorioretinopathy (CSC) with optical coherence tomography angiography (OCT-A) detected choroidal neovascularization (CNV), we performed a retrospective, interventional study. Patients were divided into 2 groups according to the fluorescein angiography: point source leakage in group 1 and diffuse oozing in group 2. Data were collected from patients including changes of best-corrected visual acuity (BCVA), size of CNV, central macular thickness (CMT), choroidal thickness (CT), reabsorption of subretinal fluid (SRF), sessions of half-dose PDT, and the number of intravitreal injections (IVI) of anti-vascular endothelial growth factor (anti-VEGF). There was a total of 34 eyes in 32 patients included. The mean sessions of half-dose PDT was 1.50 ± 0.75. The mean number of IVI of anti-VEGF was 1.38 ± 3.34. BCVA improved from 0.38 ± 0.33 to 0.20 ± 0.22 (p < 0.001). Mean CMT was significantly reduced along with reduced CT and increased size of CNV. SRF was totally reabsorbed in 31 eyes. Patients in group 1 had significant less sessions of PDT and better final BCVA. In conclusion, half-dose PDT treatment was effective for CSC with CNV. Patients with diffuse oozing in FA may fare less well with half-dose PDT.
format	article
author	Yu-Chen Hu Yi-Ling Chen Yen-Chih Chen San-Ni Chen
author_facet	Yu-Chen Hu Yi-Ling Chen Yen-Chih Chen San-Ni Chen
author_sort	Yu-Chen Hu
title	3-year follow-up of half-dose verteporfin photodynamic therapy for central serous chorioretinopathy with OCT-angiography detected choroidal neovascularization
title_short	3-year follow-up of half-dose verteporfin photodynamic therapy for central serous chorioretinopathy with OCT-angiography detected choroidal neovascularization
title_full	3-year follow-up of half-dose verteporfin photodynamic therapy for central serous chorioretinopathy with OCT-angiography detected choroidal neovascularization
title_fullStr	3-year follow-up of half-dose verteporfin photodynamic therapy for central serous chorioretinopathy with OCT-angiography detected choroidal neovascularization
title_full_unstemmed	3-year follow-up of half-dose verteporfin photodynamic therapy for central serous chorioretinopathy with OCT-angiography detected choroidal neovascularization
title_sort	3-year follow-up of half-dose verteporfin photodynamic therapy for central serous chorioretinopathy with oct-angiography detected choroidal neovascularization
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0bde7ba4bdb94ab8af65a9bf9ec81c75
work_keys_str_mv	AT yuchenhu 3yearfollowupofhalfdoseverteporfinphotodynamictherapyforcentralserouschorioretinopathywithoctangiographydetectedchoroidalneovascularization AT yilingchen 3yearfollowupofhalfdoseverteporfinphotodynamictherapyforcentralserouschorioretinopathywithoctangiographydetectedchoroidalneovascularization AT yenchihchen 3yearfollowupofhalfdoseverteporfinphotodynamictherapyforcentralserouschorioretinopathywithoctangiographydetectedchoroidalneovascularization AT sannichen 3yearfollowupofhalfdoseverteporfinphotodynamictherapyforcentralserouschorioretinopathywithoctangiographydetectedchoroidalneovascularization
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3-year follow-up of half-dose verteporfin photodynamic therapy for central serous chorioretinopathy with OCT-angiography detected choroidal neovascularization

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