Disruption of Mitochondrial Homeostasis: The Role of PINK1 in Parkinson’s Disease

The progressive reduction of the dopaminergic neurons of the substantia nigra is the fundamental process underlying Parkinson’s disease (PD), while the mechanism of susceptibility of this specific neuronal population is largely unclear. Disturbances in mitochondrial function have been recognized as...

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Autores principales:	Maria Vizziello, Linda Borellini, Giulia Franco, Gianluca Ardolino
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Parkinson’s disease PINK1 mitophagy mitochondrial quality control Parkin Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/0bdf6e3260df4524ae07a03e53a22e3a
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spelling	oai:doaj.org-article:0bdf6e3260df4524ae07a03e53a22e3a2021-11-25T17:10:31ZDisruption of Mitochondrial Homeostasis: The Role of PINK1 in Parkinson’s Disease10.3390/cells101130222073-4409https://doaj.org/article/0bdf6e3260df4524ae07a03e53a22e3a2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3022https://doaj.org/toc/2073-4409The progressive reduction of the dopaminergic neurons of the substantia nigra is the fundamental process underlying Parkinson’s disease (PD), while the mechanism of susceptibility of this specific neuronal population is largely unclear. Disturbances in mitochondrial function have been recognized as one of the main pathways in sporadic PD since the finding of respiratory chain impairment in animal models of PD. Studies on genetic forms of PD have provided new insight on the role of mitochondrial bioenergetics, homeostasis, and autophagy. PINK1 (PTEN-induced putative kinase 1) gene mutations, although rare, are the second most common cause of recessively inherited early-onset PD, after Parkin gene mutations. Our knowledge of PINK1 and Parkin function has increased dramatically in the last years, with the discovery that a process called mitophagy, which plays a key role in the maintenance of mitochondrial health, is mediated by the PINK1/Parkin pathway. In vitro and in vivo models have been developed, supporting the role of PINK1 in synaptic transmission, particularly affecting dopaminergic neurons. It is of paramount importance to further define the role of PINK1 in mitophagy and mitochondrial homeostasis in PD pathogenesis in order to delineate novel therapeutic targets.Maria VizzielloLinda BorelliniGiulia FrancoGianluca ArdolinoMDPI AGarticleParkinson’s diseasePINK1mitophagymitochondrial quality controlParkinBiology (General)QH301-705.5ENCells, Vol 10, Iss 3022, p 3022 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Parkinson’s disease PINK1 mitophagy mitochondrial quality control Parkin Biology (General) QH301-705.5
spellingShingle	Parkinson’s disease PINK1 mitophagy mitochondrial quality control Parkin Biology (General) QH301-705.5 Maria Vizziello Linda Borellini Giulia Franco Gianluca Ardolino Disruption of Mitochondrial Homeostasis: The Role of PINK1 in Parkinson’s Disease
description	The progressive reduction of the dopaminergic neurons of the substantia nigra is the fundamental process underlying Parkinson’s disease (PD), while the mechanism of susceptibility of this specific neuronal population is largely unclear. Disturbances in mitochondrial function have been recognized as one of the main pathways in sporadic PD since the finding of respiratory chain impairment in animal models of PD. Studies on genetic forms of PD have provided new insight on the role of mitochondrial bioenergetics, homeostasis, and autophagy. PINK1 (PTEN-induced putative kinase 1) gene mutations, although rare, are the second most common cause of recessively inherited early-onset PD, after Parkin gene mutations. Our knowledge of PINK1 and Parkin function has increased dramatically in the last years, with the discovery that a process called mitophagy, which plays a key role in the maintenance of mitochondrial health, is mediated by the PINK1/Parkin pathway. In vitro and in vivo models have been developed, supporting the role of PINK1 in synaptic transmission, particularly affecting dopaminergic neurons. It is of paramount importance to further define the role of PINK1 in mitophagy and mitochondrial homeostasis in PD pathogenesis in order to delineate novel therapeutic targets.
format	article
author	Maria Vizziello Linda Borellini Giulia Franco Gianluca Ardolino
author_facet	Maria Vizziello Linda Borellini Giulia Franco Gianluca Ardolino
author_sort	Maria Vizziello
title	Disruption of Mitochondrial Homeostasis: The Role of PINK1 in Parkinson’s Disease
title_short	Disruption of Mitochondrial Homeostasis: The Role of PINK1 in Parkinson’s Disease
title_full	Disruption of Mitochondrial Homeostasis: The Role of PINK1 in Parkinson’s Disease
title_fullStr	Disruption of Mitochondrial Homeostasis: The Role of PINK1 in Parkinson’s Disease
title_full_unstemmed	Disruption of Mitochondrial Homeostasis: The Role of PINK1 in Parkinson’s Disease
title_sort	disruption of mitochondrial homeostasis: the role of pink1 in parkinson’s disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0bdf6e3260df4524ae07a03e53a22e3a
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Disruption of Mitochondrial Homeostasis: The Role of PINK1 in Parkinson’s Disease

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