Incidence of stroke in the first year after diagnosis of cancer-A protocol for systematic review and meta-analysis.

<h4>Introduction</h4>There is an increased risk of stroke in patients with cancer-this risk is particularly heightened around the time of cancer diagnosis, although no studies have systematically quantified this risk in the literature. Patients newly diagnosed with cancer without prior s...

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Autores principales:	Ronda Lun, Danielle Carole Roy, Tim Ramsay, Deborah Siegal, Risa Shorr, Dean Fergusson, Dar Dowlatshahi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0be19fff07e44101878c63a347da6a03
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spelling	oai:doaj.org-article:0be19fff07e44101878c63a347da6a032021-12-02T20:08:43ZIncidence of stroke in the first year after diagnosis of cancer-A protocol for systematic review and meta-analysis.1932-620310.1371/journal.pone.0256825https://doaj.org/article/0be19fff07e44101878c63a347da6a032021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256825https://doaj.org/toc/1932-6203<h4>Introduction</h4>There is an increased risk of stroke in patients with cancer-this risk is particularly heightened around the time of cancer diagnosis, although no studies have systematically quantified this risk in the literature. Patients newly diagnosed with cancer without prior stroke represent a highly susceptible population in whom there is a window of opportunity to study and implement primary prevention strategies. Therefore, the objective of this systematic review and meta-analysis is to identify the cumulative incidence of ischemic and hemorrhagic strokes during the first year after a diagnosis of cancer.<h4>Methods and analysis</h4>MEDLINE, EMBASE, and PubMed will be searched with the assistance from a medical information specialist, from 1980 until present. Eligible studies will include observational studies that have enrolled adult patients newly diagnosed with cancer and report outcomes of stroke during the first year of cancer diagnosis. We will exclude all randomized and non-randomized interventional studies. Data on participant characteristics, study design, baseline characteristics, and outcome characteristics will be extracted. Study quality will be assessed using the Newcastle-Ottawa Scale for cohort studies, and heterogeneity will be assessed using the I2 statistic. Pooled cumulative incidence will be calculated for ischemic and hemorrhagic strokes separately using a random-effects model.<h4>Ethics and dissemination</h4>No formal research ethics approval is necessary as primary data collection will not be done. We will disseminate our findings through scientific conference presentations, peer-reviewed publications, and social media/the press. The findings from this review will inform clinicians and patients regarding the risk of stroke in patients newly diagnosed with cancer by quantifying the cumulative incidence of each subtype of stroke during the first year after a diagnosis of cancer. This represents a window of opportunity to implement prevention strategies in a susceptible population.<h4>Registration id with open science framework</h4>osf.io/ucwy9.Ronda LunDanielle Carole RoyTim RamsayDeborah SiegalRisa ShorrDean FergussonDar DowlatshahiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0256825 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ronda Lun Danielle Carole Roy Tim Ramsay Deborah Siegal Risa Shorr Dean Fergusson Dar Dowlatshahi Incidence of stroke in the first year after diagnosis of cancer-A protocol for systematic review and meta-analysis.
description	<h4>Introduction</h4>There is an increased risk of stroke in patients with cancer-this risk is particularly heightened around the time of cancer diagnosis, although no studies have systematically quantified this risk in the literature. Patients newly diagnosed with cancer without prior stroke represent a highly susceptible population in whom there is a window of opportunity to study and implement primary prevention strategies. Therefore, the objective of this systematic review and meta-analysis is to identify the cumulative incidence of ischemic and hemorrhagic strokes during the first year after a diagnosis of cancer.<h4>Methods and analysis</h4>MEDLINE, EMBASE, and PubMed will be searched with the assistance from a medical information specialist, from 1980 until present. Eligible studies will include observational studies that have enrolled adult patients newly diagnosed with cancer and report outcomes of stroke during the first year of cancer diagnosis. We will exclude all randomized and non-randomized interventional studies. Data on participant characteristics, study design, baseline characteristics, and outcome characteristics will be extracted. Study quality will be assessed using the Newcastle-Ottawa Scale for cohort studies, and heterogeneity will be assessed using the I2 statistic. Pooled cumulative incidence will be calculated for ischemic and hemorrhagic strokes separately using a random-effects model.<h4>Ethics and dissemination</h4>No formal research ethics approval is necessary as primary data collection will not be done. We will disseminate our findings through scientific conference presentations, peer-reviewed publications, and social media/the press. The findings from this review will inform clinicians and patients regarding the risk of stroke in patients newly diagnosed with cancer by quantifying the cumulative incidence of each subtype of stroke during the first year after a diagnosis of cancer. This represents a window of opportunity to implement prevention strategies in a susceptible population.<h4>Registration id with open science framework</h4>osf.io/ucwy9.
format	article
author	Ronda Lun Danielle Carole Roy Tim Ramsay Deborah Siegal Risa Shorr Dean Fergusson Dar Dowlatshahi
author_facet	Ronda Lun Danielle Carole Roy Tim Ramsay Deborah Siegal Risa Shorr Dean Fergusson Dar Dowlatshahi
author_sort	Ronda Lun
title	Incidence of stroke in the first year after diagnosis of cancer-A protocol for systematic review and meta-analysis.
title_short	Incidence of stroke in the first year after diagnosis of cancer-A protocol for systematic review and meta-analysis.
title_full	Incidence of stroke in the first year after diagnosis of cancer-A protocol for systematic review and meta-analysis.
title_fullStr	Incidence of stroke in the first year after diagnosis of cancer-A protocol for systematic review and meta-analysis.
title_full_unstemmed	Incidence of stroke in the first year after diagnosis of cancer-A protocol for systematic review and meta-analysis.
title_sort	incidence of stroke in the first year after diagnosis of cancer-a protocol for systematic review and meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/0be19fff07e44101878c63a347da6a03
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Incidence of stroke in the first year after diagnosis of cancer-A protocol for systematic review and meta-analysis.

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