Influenza A virus does not encode a tetherin antagonist with Vpu-like activity and induces IFN-dependent tetherin expression in infected cells.
The interferon-induced host cell factor tetherin inhibits release of human immunodeficiency virus (HIV) from the plasma membrane of infected cells and is counteracted by the HIV-1 protein Vpu. Influenza A virus (FLUAV) also buds from the plasma membrane and is not inhibited by tetherin. Here, we inv...
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2012
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oai:doaj.org-article:0be5a72def4e402db3c0b84be2db9b5e2021-11-18T07:07:35ZInfluenza A virus does not encode a tetherin antagonist with Vpu-like activity and induces IFN-dependent tetherin expression in infected cells.1932-620310.1371/journal.pone.0043337https://doaj.org/article/0be5a72def4e402db3c0b84be2db9b5e2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22952667/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The interferon-induced host cell factor tetherin inhibits release of human immunodeficiency virus (HIV) from the plasma membrane of infected cells and is counteracted by the HIV-1 protein Vpu. Influenza A virus (FLUAV) also buds from the plasma membrane and is not inhibited by tetherin. Here, we investigated if FLUAV encodes a functional equivalent of Vpu for tetherin antagonism. We found that expression of the FLUAV protein NS1, which antagonizes the interferon (IFN) response, did not block the tetherin-mediated restriction of HIV release, which was rescued by Vpu. Similarly, tetherin-mediated inhibition of HIV release was not rescued by FLUAV infection. In contrast, FLUAV infection induced tetherin expression on target cells in an IFN-dependent manner. These results suggest that FLUAV escapes the antiviral effects of tetherin without encoding a tetherin antagonist with Vpu-like activity.Michael WinklerStephanie BertramKerstin GnirßInga NehlmeierAli GawanbachtFrank KirchhoffChristina EhrhardtStephan LudwigMiriam KieneAnna-Sophie MoldenhauerUlrike GoedeckeChristina B KarstenAnnika KühlStefan PöhlmannPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 8, p e43337 (2012) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Medicine R Science Q |
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Medicine R Science Q Michael Winkler Stephanie Bertram Kerstin Gnirß Inga Nehlmeier Ali Gawanbacht Frank Kirchhoff Christina Ehrhardt Stephan Ludwig Miriam Kiene Anna-Sophie Moldenhauer Ulrike Goedecke Christina B Karsten Annika Kühl Stefan Pöhlmann Influenza A virus does not encode a tetherin antagonist with Vpu-like activity and induces IFN-dependent tetherin expression in infected cells. |
| description |
The interferon-induced host cell factor tetherin inhibits release of human immunodeficiency virus (HIV) from the plasma membrane of infected cells and is counteracted by the HIV-1 protein Vpu. Influenza A virus (FLUAV) also buds from the plasma membrane and is not inhibited by tetherin. Here, we investigated if FLUAV encodes a functional equivalent of Vpu for tetherin antagonism. We found that expression of the FLUAV protein NS1, which antagonizes the interferon (IFN) response, did not block the tetherin-mediated restriction of HIV release, which was rescued by Vpu. Similarly, tetherin-mediated inhibition of HIV release was not rescued by FLUAV infection. In contrast, FLUAV infection induced tetherin expression on target cells in an IFN-dependent manner. These results suggest that FLUAV escapes the antiviral effects of tetherin without encoding a tetherin antagonist with Vpu-like activity. |
| format |
article |
| author |
Michael Winkler Stephanie Bertram Kerstin Gnirß Inga Nehlmeier Ali Gawanbacht Frank Kirchhoff Christina Ehrhardt Stephan Ludwig Miriam Kiene Anna-Sophie Moldenhauer Ulrike Goedecke Christina B Karsten Annika Kühl Stefan Pöhlmann |
| author_facet |
Michael Winkler Stephanie Bertram Kerstin Gnirß Inga Nehlmeier Ali Gawanbacht Frank Kirchhoff Christina Ehrhardt Stephan Ludwig Miriam Kiene Anna-Sophie Moldenhauer Ulrike Goedecke Christina B Karsten Annika Kühl Stefan Pöhlmann |
| author_sort |
Michael Winkler |
| title |
Influenza A virus does not encode a tetherin antagonist with Vpu-like activity and induces IFN-dependent tetherin expression in infected cells. |
| title_short |
Influenza A virus does not encode a tetherin antagonist with Vpu-like activity and induces IFN-dependent tetherin expression in infected cells. |
| title_full |
Influenza A virus does not encode a tetherin antagonist with Vpu-like activity and induces IFN-dependent tetherin expression in infected cells. |
| title_fullStr |
Influenza A virus does not encode a tetherin antagonist with Vpu-like activity and induces IFN-dependent tetherin expression in infected cells. |
| title_full_unstemmed |
Influenza A virus does not encode a tetherin antagonist with Vpu-like activity and induces IFN-dependent tetherin expression in infected cells. |
| title_sort |
influenza a virus does not encode a tetherin antagonist with vpu-like activity and induces ifn-dependent tetherin expression in infected cells. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/0be5a72def4e402db3c0b84be2db9b5e |
| work_keys_str_mv |
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| _version_ |
1718423896700485632 |