Comparison of cytocompatibility and anticancer properties of traditional and green chemistry-synthesized tellurium nanowires

Ada Vernet Crua,1–3,* David Medina,1,2,* Bohan Zhang,1,2 María Ujué González,4 Yves Huttel,5 José Miguel García-Martín,4 Jorge L Cholula-Díaz,6 Thomas J Webster1,21Department of Chemical Engineering, Northeastern...

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Autores principales:	Vernet Crua A, Medina D, Zhang B, González MU, Huttel Y, García-Martín JM, Cholula-Díaz JL, Webster TJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	nanowires tellurium biocompatibility anticancer green chemistry Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0be5daad277b45a1a9c6bf374fcdad07
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spelling	oai:doaj.org-article:0be5daad277b45a1a9c6bf374fcdad072021-12-02T07:52:51ZComparison of cytocompatibility and anticancer properties of traditional and green chemistry-synthesized tellurium nanowires1178-2013https://doaj.org/article/0be5daad277b45a1a9c6bf374fcdad072019-05-01T00:00:00Zhttps://www.dovepress.com/comparison-of-cytocompatibility-and-anticancer-properties-of-tradititi-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Ada Vernet Crua,1–3,* David Medina,1,2,* Bohan Zhang,1,2 María Ujué González,4 Yves Huttel,5 José Miguel García-Martín,4 Jorge L Cholula-Díaz,6 Thomas J Webster1,21Department of Chemical Engineering, Northeastern University, Boston, MA, USA; 2Nanomedicine Science and Technology Center, Northeastern University, Boston, MA, USA; 3Universitat Rovira I Virgili, Tarragona, Spain; 4Instituto de Micro y Nanotechnologia, IMN-CNM, CSIC (CEI UAM+CSIC), Tres Cantos, Spain; 5Materials Science Factory, Instituto de Ciencias de Materiales, ICMN-CSIC, Madrid, Spain; 6School of Engineering and Sciences, Tecnologico de Monterrey, Monterrey, NL, Mexico *These authors contributed equally to this workBackground: Tradiditional physicochemical approaches for the synthesis of compounds, drugs, and nanostructures developed as potential solutions for antimicrobial resistance or against cancer treatment are, for the most part, facile and straightforward. Nevertheless, these approaches have several limitations, such as the use of toxic chemicals and production of toxic by-products with limited biocompatibility. Therefore, new methods are needed to address these limitations, and green chemistry offers a suitable and novel answer, with the safe and environmentally friendly design, manufacturing, and use of minimally toxic chemicals. Green chemistry approaches are especially useful for the generation of metallic nanoparticles or nanometric structures that can effectively and efficiently address health care concerns. Objective: Here, tellurium (Te) nanowires were synthesized using a novel green chemistry approach, and their structures and cytocompatibility were evaluated. Method: An easy and straightforward hydrothermal method was employed, and the Te nanowires were characterized using transmission electron microscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy, Fourier-transform infrared spectroscopy, X-ray powder diffraction, X-ray photoelectron spectroscopy, and optical microscopy for morphology, size, and chemistry. Cytotoxicity tests were performed with human dermal fibroblasts and human melanoma cells (to assess anticancer properties). The results showed that a treatment with Te nanowires at concentrations between 5 and 100 µg/mL improved the proliferation of healthy cells and decreased cancerous cell growth over a 5-day period. Most importantly, the green chemistry -synthesized Te nanowires outperformed those produced by traditional synthetic chemical methods. Conclusion: This study suggests that green chemistry approaches for producing Te nanostructures may not only reduce adverse environmental effects resulting from traditional synthetic chemistry methods, but also be more effective in numerous health care applications. Keywords: nanowires, tellurium, biocompatibility, anticancer, green chemistryVernet Crua AMedina DZhang BGonzález MUHuttel YGarcía-Martín JMCholula-Díaz JLWebster TJDove Medical Pressarticlenanowirestelluriumbiocompatibilityanticancergreen chemistryMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 3155-3176 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanowires tellurium biocompatibility anticancer green chemistry Medicine (General) R5-920
spellingShingle	nanowires tellurium biocompatibility anticancer green chemistry Medicine (General) R5-920 Vernet Crua A Medina D Zhang B González MU Huttel Y García-Martín JM Cholula-Díaz JL Webster TJ Comparison of cytocompatibility and anticancer properties of traditional and green chemistry-synthesized tellurium nanowires
description	Ada Vernet Crua,1–3,* David Medina,1,2,* Bohan Zhang,1,2 María Ujué González,4 Yves Huttel,5 José Miguel García-Martín,4 Jorge L Cholula-Díaz,6 Thomas J Webster1,21Department of Chemical Engineering, Northeastern University, Boston, MA, USA; 2Nanomedicine Science and Technology Center, Northeastern University, Boston, MA, USA; 3Universitat Rovira I Virgili, Tarragona, Spain; 4Instituto de Micro y Nanotechnologia, IMN-CNM, CSIC (CEI UAM+CSIC), Tres Cantos, Spain; 5Materials Science Factory, Instituto de Ciencias de Materiales, ICMN-CSIC, Madrid, Spain; 6School of Engineering and Sciences, Tecnologico de Monterrey, Monterrey, NL, Mexico *These authors contributed equally to this workBackground: Tradiditional physicochemical approaches for the synthesis of compounds, drugs, and nanostructures developed as potential solutions for antimicrobial resistance or against cancer treatment are, for the most part, facile and straightforward. Nevertheless, these approaches have several limitations, such as the use of toxic chemicals and production of toxic by-products with limited biocompatibility. Therefore, new methods are needed to address these limitations, and green chemistry offers a suitable and novel answer, with the safe and environmentally friendly design, manufacturing, and use of minimally toxic chemicals. Green chemistry approaches are especially useful for the generation of metallic nanoparticles or nanometric structures that can effectively and efficiently address health care concerns. Objective: Here, tellurium (Te) nanowires were synthesized using a novel green chemistry approach, and their structures and cytocompatibility were evaluated. Method: An easy and straightforward hydrothermal method was employed, and the Te nanowires were characterized using transmission electron microscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy, Fourier-transform infrared spectroscopy, X-ray powder diffraction, X-ray photoelectron spectroscopy, and optical microscopy for morphology, size, and chemistry. Cytotoxicity tests were performed with human dermal fibroblasts and human melanoma cells (to assess anticancer properties). The results showed that a treatment with Te nanowires at concentrations between 5 and 100 µg/mL improved the proliferation of healthy cells and decreased cancerous cell growth over a 5-day period. Most importantly, the green chemistry -synthesized Te nanowires outperformed those produced by traditional synthetic chemical methods. Conclusion: This study suggests that green chemistry approaches for producing Te nanostructures may not only reduce adverse environmental effects resulting from traditional synthetic chemistry methods, but also be more effective in numerous health care applications. Keywords: nanowires, tellurium, biocompatibility, anticancer, green chemistry
format	article
author	Vernet Crua A Medina D Zhang B González MU Huttel Y García-Martín JM Cholula-Díaz JL Webster TJ
author_facet	Vernet Crua A Medina D Zhang B González MU Huttel Y García-Martín JM Cholula-Díaz JL Webster TJ
author_sort	Vernet Crua A
title	Comparison of cytocompatibility and anticancer properties of traditional and green chemistry-synthesized tellurium nanowires
title_short	Comparison of cytocompatibility and anticancer properties of traditional and green chemistry-synthesized tellurium nanowires
title_full	Comparison of cytocompatibility and anticancer properties of traditional and green chemistry-synthesized tellurium nanowires
title_fullStr	Comparison of cytocompatibility and anticancer properties of traditional and green chemistry-synthesized tellurium nanowires
title_full_unstemmed	Comparison of cytocompatibility and anticancer properties of traditional and green chemistry-synthesized tellurium nanowires
title_sort	comparison of cytocompatibility and anticancer properties of traditional and green chemistry-synthesized tellurium nanowires
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/0be5daad277b45a1a9c6bf374fcdad07
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Comparison of cytocompatibility and anticancer properties of traditional and green chemistry-synthesized tellurium nanowires

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