The role and mechanism of CARD9 gene polymorphism in diseases

CARD9 is a cytosolic adaptor in myeloid cells, has a critical role in inflammatory disorders, and provides a protective function against microbial pathogen, especially fungal infection. Recently, CARD9 polymorphisms are of interest, showing a positive correlation with the elevated risk of fungal inf...

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Autores principales:	Changxue Ji, Zhiwen Yang, Xiaoming Zhong, Jindong Xia
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	CARD9 polymorphisms Inflammatory Infection Autoimmune diseases Medicine (General) R5-920 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/0be60a1d8d0e435aad3618ab9c2a50dc
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spelling	oai:doaj.org-article:0be60a1d8d0e435aad3618ab9c2a50dc2021-11-28T04:33:09ZThe role and mechanism of CARD9 gene polymorphism in diseases2319-417010.1016/j.bj.2020.12.006https://doaj.org/article/0be60a1d8d0e435aad3618ab9c2a50dc2021-10-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2319417020302341https://doaj.org/toc/2319-4170CARD9 is a cytosolic adaptor in myeloid cells, has a critical role in inflammatory disorders, and provides a protective function against microbial pathogen, especially fungal infection. Recently, CARD9 polymorphisms are of interest, showing a positive correlation with the elevated risk of fungal infection, inflammatory bowel disease, and other autoimmune diseases. Mechanistically, CARD9 polymorphisms impair the activation of RelB, a subunit of non-canonical NF-κB, which lead to the reduced cytokine and chemokine production by innate immune cells. In addition, CARD9 polymorphisms show a defective neutrophil accumulation in infectious sites. Furthermore, CARD9 polymorphisms could alter the composition of the gut microbiome. In this review, we summarize the latest findings of CARD9 polymorphisms with respect to inflammatory diseases.Changxue JiZhiwen YangXiaoming ZhongJindong XiaElsevierarticleCARD9 polymorphismsInflammatoryInfectionAutoimmune diseasesMedicine (General)R5-920Biology (General)QH301-705.5ENBiomedical Journal, Vol 44, Iss 5, Pp 560-566 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	CARD9 polymorphisms Inflammatory Infection Autoimmune diseases Medicine (General) R5-920 Biology (General) QH301-705.5
spellingShingle	CARD9 polymorphisms Inflammatory Infection Autoimmune diseases Medicine (General) R5-920 Biology (General) QH301-705.5 Changxue Ji Zhiwen Yang Xiaoming Zhong Jindong Xia The role and mechanism of CARD9 gene polymorphism in diseases
description	CARD9 is a cytosolic adaptor in myeloid cells, has a critical role in inflammatory disorders, and provides a protective function against microbial pathogen, especially fungal infection. Recently, CARD9 polymorphisms are of interest, showing a positive correlation with the elevated risk of fungal infection, inflammatory bowel disease, and other autoimmune diseases. Mechanistically, CARD9 polymorphisms impair the activation of RelB, a subunit of non-canonical NF-κB, which lead to the reduced cytokine and chemokine production by innate immune cells. In addition, CARD9 polymorphisms show a defective neutrophil accumulation in infectious sites. Furthermore, CARD9 polymorphisms could alter the composition of the gut microbiome. In this review, we summarize the latest findings of CARD9 polymorphisms with respect to inflammatory diseases.
format	article
author	Changxue Ji Zhiwen Yang Xiaoming Zhong Jindong Xia
author_facet	Changxue Ji Zhiwen Yang Xiaoming Zhong Jindong Xia
author_sort	Changxue Ji
title	The role and mechanism of CARD9 gene polymorphism in diseases
title_short	The role and mechanism of CARD9 gene polymorphism in diseases
title_full	The role and mechanism of CARD9 gene polymorphism in diseases
title_fullStr	The role and mechanism of CARD9 gene polymorphism in diseases
title_full_unstemmed	The role and mechanism of CARD9 gene polymorphism in diseases
title_sort	role and mechanism of card9 gene polymorphism in diseases
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/0be60a1d8d0e435aad3618ab9c2a50dc
work_keys_str_mv	AT changxueji theroleandmechanismofcard9genepolymorphismindiseases AT zhiwenyang theroleandmechanismofcard9genepolymorphismindiseases AT xiaomingzhong theroleandmechanismofcard9genepolymorphismindiseases AT jindongxia theroleandmechanismofcard9genepolymorphismindiseases AT changxueji roleandmechanismofcard9genepolymorphismindiseases AT zhiwenyang roleandmechanismofcard9genepolymorphismindiseases AT xiaomingzhong roleandmechanismofcard9genepolymorphismindiseases AT jindongxia roleandmechanismofcard9genepolymorphismindiseases
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The role and mechanism of CARD9 gene polymorphism in diseases

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