GWAS for autoimmune Addison’s disease identifies multiple risk loci and highlights AIRE in disease susceptibility

GWAS for autoimmune Addison’s disease identifies multiple risk loci and highlights AIRE in disease susceptibility

Autoimmune Addison’s disease is a rare complex disease, which has not yet been characterized by non-biased genetic studies. Here, the authors perform the first GWAS for the disease, identifying nine loci including two coding variants in the gene Autoimmune Regulator (AIRE).

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Autores principales: Daniel Eriksson, Ellen Christine Røyrvik, Maribel Aranda-Guillén, Amund Holte Berger, Nils Landegren, Haydee Artaza, Åsa Hallgren, Marianne Aardal Grytaas, Sara Ström, Eirik Bratland, Ileana Ruxandra Botusan, Bergithe Eikeland Oftedal, Lars Breivik, Marc Vaudel, Øyvind Helgeland, Alberto Falorni, Anders Palmstrøm Jørgensen, Anna-Lena Hulting, Johan Svartberg, Olov Ekwall, Kristian Johan Fougner, Jeanette Wahlberg, Bjørn Gunnar Nedrebø, Per Dahlqvist, The Norwegian Addison Registry Study Group, The Swedish Addison Registry Study Group, Per Morten Knappskog, Anette Susanne Bøe Wolff, Sophie Bensing, Stefan Johansson, Olle Kämpe, Eystein Sverre Husebye
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/0be85e9204274eff9b1cb72be80b2205
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spelling oai:doaj.org-article:0be85e9204274eff9b1cb72be80b22052021-12-02T14:10:56ZGWAS for autoimmune Addison’s disease identifies multiple risk loci and highlights AIRE in disease susceptibility10.1038/s41467-021-21015-82041-1723https://doaj.org/article/0be85e9204274eff9b1cb72be80b22052021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21015-8https://doaj.org/toc/2041-1723Autoimmune Addison’s disease is a rare complex disease, which has not yet been characterized by non-biased genetic studies. Here, the authors perform the first GWAS for the disease, identifying nine loci including two coding variants in the gene Autoimmune Regulator (AIRE).Daniel ErikssonEllen Christine RøyrvikMaribel Aranda-GuillénAmund Holte BergerNils LandegrenHaydee ArtazaÅsa HallgrenMarianne Aardal GrytaasSara StrömEirik BratlandIleana Ruxandra BotusanBergithe Eikeland OftedalLars BreivikMarc VaudelØyvind HelgelandAlberto FalorniAnders Palmstrøm JørgensenAnna-Lena HultingJohan SvartbergOlov EkwallKristian Johan FougnerJeanette WahlbergBjørn Gunnar NedrebøPer DahlqvistThe Norwegian Addison Registry Study GroupThe Swedish Addison Registry Study GroupPer Morten KnappskogAnette Susanne Bøe WolffSophie BensingStefan JohanssonOlle KämpeEystein Sverre HusebyeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Daniel Eriksson
Ellen Christine Røyrvik
Maribel Aranda-Guillén
Amund Holte Berger
Nils Landegren
Haydee Artaza
Åsa Hallgren
Marianne Aardal Grytaas
Sara Ström
Eirik Bratland
Ileana Ruxandra Botusan
Bergithe Eikeland Oftedal
Lars Breivik
Marc Vaudel
Øyvind Helgeland
Alberto Falorni
Anders Palmstrøm Jørgensen
Anna-Lena Hulting
Johan Svartberg
Olov Ekwall
Kristian Johan Fougner
Jeanette Wahlberg
Bjørn Gunnar Nedrebø
Per Dahlqvist
The Norwegian Addison Registry Study Group
The Swedish Addison Registry Study Group
Per Morten Knappskog
Anette Susanne Bøe Wolff
Sophie Bensing
Stefan Johansson
Olle Kämpe
Eystein Sverre Husebye
GWAS for autoimmune Addison’s disease identifies multiple risk loci and highlights AIRE in disease susceptibility
description Autoimmune Addison’s disease is a rare complex disease, which has not yet been characterized by non-biased genetic studies. Here, the authors perform the first GWAS for the disease, identifying nine loci including two coding variants in the gene Autoimmune Regulator (AIRE).
format article
author Daniel Eriksson
Ellen Christine Røyrvik
Maribel Aranda-Guillén
Amund Holte Berger
Nils Landegren
Haydee Artaza
Åsa Hallgren
Marianne Aardal Grytaas
Sara Ström
Eirik Bratland
Ileana Ruxandra Botusan
Bergithe Eikeland Oftedal
Lars Breivik
Marc Vaudel
Øyvind Helgeland
Alberto Falorni
Anders Palmstrøm Jørgensen
Anna-Lena Hulting
Johan Svartberg
Olov Ekwall
Kristian Johan Fougner
Jeanette Wahlberg
Bjørn Gunnar Nedrebø
Per Dahlqvist
The Norwegian Addison Registry Study Group
The Swedish Addison Registry Study Group
Per Morten Knappskog
Anette Susanne Bøe Wolff
Sophie Bensing
Stefan Johansson
Olle Kämpe
Eystein Sverre Husebye
author_facet Daniel Eriksson
Ellen Christine Røyrvik
Maribel Aranda-Guillén
Amund Holte Berger
Nils Landegren
Haydee Artaza
Åsa Hallgren
Marianne Aardal Grytaas
Sara Ström
Eirik Bratland
Ileana Ruxandra Botusan
Bergithe Eikeland Oftedal
Lars Breivik
Marc Vaudel
Øyvind Helgeland
Alberto Falorni
Anders Palmstrøm Jørgensen
Anna-Lena Hulting
Johan Svartberg
Olov Ekwall
Kristian Johan Fougner
Jeanette Wahlberg
Bjørn Gunnar Nedrebø
Per Dahlqvist
The Norwegian Addison Registry Study Group
The Swedish Addison Registry Study Group
Per Morten Knappskog
Anette Susanne Bøe Wolff
Sophie Bensing
Stefan Johansson
Olle Kämpe
Eystein Sverre Husebye
author_sort Daniel Eriksson
title GWAS for autoimmune Addison’s disease identifies multiple risk loci and highlights AIRE in disease susceptibility
title_short GWAS for autoimmune Addison’s disease identifies multiple risk loci and highlights AIRE in disease susceptibility
title_full GWAS for autoimmune Addison’s disease identifies multiple risk loci and highlights AIRE in disease susceptibility
title_fullStr GWAS for autoimmune Addison’s disease identifies multiple risk loci and highlights AIRE in disease susceptibility
title_full_unstemmed GWAS for autoimmune Addison’s disease identifies multiple risk loci and highlights AIRE in disease susceptibility
title_sort gwas for autoimmune addison’s disease identifies multiple risk loci and highlights aire in disease susceptibility
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/0be85e9204274eff9b1cb72be80b2205
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