Architectural control of metabolic plasticity in epithelial cancer cells

To understand the role of architectural environment on metabolic plasticity of cancer cells, Al Masri et al. compare the metabolic activities of cancer cells grown in 2D vs 3D. They find that cells cultivated in 2D are highly glycolytic and dependent on glucose and glutamine for growth, while cells...

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Autores principales:	Maia Al-Masri, Karina Paliotti, Raymond Tran, Ruba Halaoui, Virginie Lelarge, Sudipa Chatterjee, Li-Ting Wang, Christopher Moraes, Luke McCaffrey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/0be89b27d5bc4496a6aa395fe7556199
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spelling	oai:doaj.org-article:0be89b27d5bc4496a6aa395fe75561992021-12-02T17:05:09ZArchitectural control of metabolic plasticity in epithelial cancer cells10.1038/s42003-021-01899-42399-3642https://doaj.org/article/0be89b27d5bc4496a6aa395fe75561992021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01899-4https://doaj.org/toc/2399-3642To understand the role of architectural environment on metabolic plasticity of cancer cells, Al Masri et al. compare the metabolic activities of cancer cells grown in 2D vs 3D. They find that cells cultivated in 2D are highly glycolytic and dependent on glucose and glutamine for growth, while cells cultivated in 3D have extensive metabolic plasticity, and are able to maintain growth even in glucose or amino acid depleted environment.Maia Al-MasriKarina PaliottiRaymond TranRuba HalaouiVirginie LelargeSudipa ChatterjeeLi-Ting WangChristopher MoraesLuke McCaffreyNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Maia Al-Masri Karina Paliotti Raymond Tran Ruba Halaoui Virginie Lelarge Sudipa Chatterjee Li-Ting Wang Christopher Moraes Luke McCaffrey Architectural control of metabolic plasticity in epithelial cancer cells
description	To understand the role of architectural environment on metabolic plasticity of cancer cells, Al Masri et al. compare the metabolic activities of cancer cells grown in 2D vs 3D. They find that cells cultivated in 2D are highly glycolytic and dependent on glucose and glutamine for growth, while cells cultivated in 3D have extensive metabolic plasticity, and are able to maintain growth even in glucose or amino acid depleted environment.
format	article
author	Maia Al-Masri Karina Paliotti Raymond Tran Ruba Halaoui Virginie Lelarge Sudipa Chatterjee Li-Ting Wang Christopher Moraes Luke McCaffrey
author_facet	Maia Al-Masri Karina Paliotti Raymond Tran Ruba Halaoui Virginie Lelarge Sudipa Chatterjee Li-Ting Wang Christopher Moraes Luke McCaffrey
author_sort	Maia Al-Masri
title	Architectural control of metabolic plasticity in epithelial cancer cells
title_short	Architectural control of metabolic plasticity in epithelial cancer cells
title_full	Architectural control of metabolic plasticity in epithelial cancer cells
title_fullStr	Architectural control of metabolic plasticity in epithelial cancer cells
title_full_unstemmed	Architectural control of metabolic plasticity in epithelial cancer cells
title_sort	architectural control of metabolic plasticity in epithelial cancer cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0be89b27d5bc4496a6aa395fe7556199
work_keys_str_mv	AT maiaalmasri architecturalcontrolofmetabolicplasticityinepithelialcancercells AT karinapaliotti architecturalcontrolofmetabolicplasticityinepithelialcancercells AT raymondtran architecturalcontrolofmetabolicplasticityinepithelialcancercells AT rubahalaoui architecturalcontrolofmetabolicplasticityinepithelialcancercells AT virginielelarge architecturalcontrolofmetabolicplasticityinepithelialcancercells AT sudipachatterjee architecturalcontrolofmetabolicplasticityinepithelialcancercells AT litingwang architecturalcontrolofmetabolicplasticityinepithelialcancercells AT christophermoraes architecturalcontrolofmetabolicplasticityinepithelialcancercells AT lukemccaffrey architecturalcontrolofmetabolicplasticityinepithelialcancercells
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Architectural control of metabolic plasticity in epithelial cancer cells

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