H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis

Lysine27-to-methionine mutations in histone H3 genes (H3K27M) occur in a subgroup of gliomas and decrease genome-wide H3K27 trimethylation. Here the authors utilise primary H3K27M tumour lines and isogenic CRISPR-edited controls and show that H3K27M induces defective chromatin spread of PRC2-mediate...

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Autores principales:	Ashot S. Harutyunyan, Brian Krug, Haifen Chen, Simon Papillon-Cavanagh, Michele Zeinieh, Nicolas De Jay, Shriya Deshmukh, Carol C. L. Chen, Jad Belle, Leonie G. Mikael, Dylan M. Marchione, Rui Li, Hamid Nikbakht, Bo Hu, Gael Cagnone, Warren A. Cheung, Abdulshakour Mohammadnia, Denise Bechet, Damien Faury, Melissa K McConechy, Manav Pathania, Siddhant U. Jain, Benjamin Ellezam, Alexander G. Weil, Alexandre Montpetit, Paolo Salomoni, Tomi Pastinen, Chao Lu, Peter W. Lewis, Benjamin A. Garcia, Claudia L. Kleinman, Nada Jabado, Jacek Majewski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0beae741fed94f66b31dab929cbfe1ba
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spelling	oai:doaj.org-article:0beae741fed94f66b31dab929cbfe1ba2021-12-02T17:01:37ZH3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis10.1038/s41467-019-09140-x2041-1723https://doaj.org/article/0beae741fed94f66b31dab929cbfe1ba2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09140-xhttps://doaj.org/toc/2041-1723Lysine27-to-methionine mutations in histone H3 genes (H3K27M) occur in a subgroup of gliomas and decrease genome-wide H3K27 trimethylation. Here the authors utilise primary H3K27M tumour lines and isogenic CRISPR-edited controls and show that H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3.Ashot S. HarutyunyanBrian KrugHaifen ChenSimon Papillon-CavanaghMichele ZeiniehNicolas De JayShriya DeshmukhCarol C. L. ChenJad BelleLeonie G. MikaelDylan M. MarchioneRui LiHamid NikbakhtBo HuGael CagnoneWarren A. CheungAbdulshakour MohammadniaDenise BechetDamien FauryMelissa K McConechyManav PathaniaSiddhant U. JainBenjamin EllezamAlexander G. WeilAlexandre MontpetitPaolo SalomoniTomi PastinenChao LuPeter W. LewisBenjamin A. GarciaClaudia L. KleinmanNada JabadoJacek MajewskiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ashot S. Harutyunyan Brian Krug Haifen Chen Simon Papillon-Cavanagh Michele Zeinieh Nicolas De Jay Shriya Deshmukh Carol C. L. Chen Jad Belle Leonie G. Mikael Dylan M. Marchione Rui Li Hamid Nikbakht Bo Hu Gael Cagnone Warren A. Cheung Abdulshakour Mohammadnia Denise Bechet Damien Faury Melissa K McConechy Manav Pathania Siddhant U. Jain Benjamin Ellezam Alexander G. Weil Alexandre Montpetit Paolo Salomoni Tomi Pastinen Chao Lu Peter W. Lewis Benjamin A. Garcia Claudia L. Kleinman Nada Jabado Jacek Majewski H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis
description	Lysine27-to-methionine mutations in histone H3 genes (H3K27M) occur in a subgroup of gliomas and decrease genome-wide H3K27 trimethylation. Here the authors utilise primary H3K27M tumour lines and isogenic CRISPR-edited controls and show that H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3.
format	article
author	Ashot S. Harutyunyan Brian Krug Haifen Chen Simon Papillon-Cavanagh Michele Zeinieh Nicolas De Jay Shriya Deshmukh Carol C. L. Chen Jad Belle Leonie G. Mikael Dylan M. Marchione Rui Li Hamid Nikbakht Bo Hu Gael Cagnone Warren A. Cheung Abdulshakour Mohammadnia Denise Bechet Damien Faury Melissa K McConechy Manav Pathania Siddhant U. Jain Benjamin Ellezam Alexander G. Weil Alexandre Montpetit Paolo Salomoni Tomi Pastinen Chao Lu Peter W. Lewis Benjamin A. Garcia Claudia L. Kleinman Nada Jabado Jacek Majewski
author_facet	Ashot S. Harutyunyan Brian Krug Haifen Chen Simon Papillon-Cavanagh Michele Zeinieh Nicolas De Jay Shriya Deshmukh Carol C. L. Chen Jad Belle Leonie G. Mikael Dylan M. Marchione Rui Li Hamid Nikbakht Bo Hu Gael Cagnone Warren A. Cheung Abdulshakour Mohammadnia Denise Bechet Damien Faury Melissa K McConechy Manav Pathania Siddhant U. Jain Benjamin Ellezam Alexander G. Weil Alexandre Montpetit Paolo Salomoni Tomi Pastinen Chao Lu Peter W. Lewis Benjamin A. Garcia Claudia L. Kleinman Nada Jabado Jacek Majewski
author_sort	Ashot S. Harutyunyan
title	H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis
title_short	H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis
title_full	H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis
title_fullStr	H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis
title_full_unstemmed	H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis
title_sort	h3k27m induces defective chromatin spread of prc2-mediated repressive h3k27me2/me3 and is essential for glioma tumorigenesis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0beae741fed94f66b31dab929cbfe1ba
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H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis

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