Methanol extracts of Fagara zanthoxyloides leaves possess antimalarial effects and normalizes haematological and biochemical status of Plasmodium berghei-passaged mice

Context: The resistance of Plasmodium species to many available antimalarials calls for a continuous search for newer antimalarial agents. One possible source of new antimalarials is from natural sources such as Fagara zanthoxyloides Lam (Rutaceae), a medicinal plant used traditionally for treating...

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Autores principales:	Osmund Chukwuma Enechi, Christian Chijioke Amah, Innocent Uzochukwu Okagu, Chidinma Pamela Ononiwu, Vitalis Chukwumalume Azidiegwu, Eberechukwu Ogochukwu Ugwuoke, Amarachukwu Pearl Onoh, Emmanuel Elekweuwa Ndukwe
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2019
Materias:	medicinal plants kidney oxidative stress antioxidants liver Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/0beb65fcd6c849d681201ae91f62af78
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spelling	oai:doaj.org-article:0beb65fcd6c849d681201ae91f62af782021-11-17T14:21:56ZMethanol extracts of Fagara zanthoxyloides leaves possess antimalarial effects and normalizes haematological and biochemical status of Plasmodium berghei-passaged mice1388-02091744-511610.1080/13880209.2019.1656753https://doaj.org/article/0beb65fcd6c849d681201ae91f62af782019-01-01T00:00:00Zhttp://dx.doi.org/10.1080/13880209.2019.1656753https://doaj.org/toc/1388-0209https://doaj.org/toc/1744-5116Context: The resistance of Plasmodium species to many available antimalarials calls for a continuous search for newer antimalarial agents. One possible source of new antimalarials is from natural sources such as Fagara zanthoxyloides Lam (Rutaceae), a medicinal plant used traditionally for treating malaria in South-Eastern Nigeria, Uganda and Asia. Objectives: To investigate the application of methanol extracts of F. zanthoxyloides in combating malaria infection and its associated disorders. Materials and methods: Methanol extracts of F. zanthoxyloides leaves (MEFZ) were evaluated for in vivo antimalarial activity. MEFZ at doses of 200, 400, and 600 mg/kg/d were administered orally for 4 consecutive days (days 0–4) to P. berghei-infected mice. The possible ameliorative effects of MEFZ on malaria-associated organ malfunctions were also assessed. Results: At 200, 400 and 600 mg/kg b.w., respectively, MEFZ produced 82.37% and 68.39%, 84.84%, and 90.75%, 95.95% and 92.67% chemosuppression and inhibition of P. berghei, respectively, comparable to 98.67% and 97.29% by combisunate, a standard antimalarial. The IC50 of MEFZ was estimated to be 235.23 mg/kg b.w. Similarly, treatment of parasitized mice with MEFZ significantly restored the malaria-modified haematological and biochemical status of the parasitized-MEFZ-treated mice compared with parasitized-untreated mice. MEFZ was tolerable up to 5000 mg/kg b.w dose; hence, the LD50 is above 5000 mg/kg b.w. Discussion and conclusions: The results of this curative assay demonstrated that MEFZ has antimalarial effects and normalized haematological and biochemical aberrations generated by malaria. The isolation of the antimalarial principles in MEFZ is warranted; they could be lead molecules for the development of new antimalarials.Osmund Chukwuma EnechiChristian Chijioke AmahInnocent Uzochukwu OkaguChidinma Pamela OnoniwuVitalis Chukwumalume AzidiegwuEberechukwu Ogochukwu UgwuokeAmarachukwu Pearl OnohEmmanuel Elekweuwa NdukweTaylor & Francis Grouparticlemedicinal plantskidneyoxidative stressantioxidantsliverTherapeutics. PharmacologyRM1-950ENPharmaceutical Biology, Vol 57, Iss 1, Pp 577-585 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	medicinal plants kidney oxidative stress antioxidants liver Therapeutics. Pharmacology RM1-950
spellingShingle	medicinal plants kidney oxidative stress antioxidants liver Therapeutics. Pharmacology RM1-950 Osmund Chukwuma Enechi Christian Chijioke Amah Innocent Uzochukwu Okagu Chidinma Pamela Ononiwu Vitalis Chukwumalume Azidiegwu Eberechukwu Ogochukwu Ugwuoke Amarachukwu Pearl Onoh Emmanuel Elekweuwa Ndukwe Methanol extracts of Fagara zanthoxyloides leaves possess antimalarial effects and normalizes haematological and biochemical status of Plasmodium berghei-passaged mice
description	Context: The resistance of Plasmodium species to many available antimalarials calls for a continuous search for newer antimalarial agents. One possible source of new antimalarials is from natural sources such as Fagara zanthoxyloides Lam (Rutaceae), a medicinal plant used traditionally for treating malaria in South-Eastern Nigeria, Uganda and Asia. Objectives: To investigate the application of methanol extracts of F. zanthoxyloides in combating malaria infection and its associated disorders. Materials and methods: Methanol extracts of F. zanthoxyloides leaves (MEFZ) were evaluated for in vivo antimalarial activity. MEFZ at doses of 200, 400, and 600 mg/kg/d were administered orally for 4 consecutive days (days 0–4) to P. berghei-infected mice. The possible ameliorative effects of MEFZ on malaria-associated organ malfunctions were also assessed. Results: At 200, 400 and 600 mg/kg b.w., respectively, MEFZ produced 82.37% and 68.39%, 84.84%, and 90.75%, 95.95% and 92.67% chemosuppression and inhibition of P. berghei, respectively, comparable to 98.67% and 97.29% by combisunate, a standard antimalarial. The IC50 of MEFZ was estimated to be 235.23 mg/kg b.w. Similarly, treatment of parasitized mice with MEFZ significantly restored the malaria-modified haematological and biochemical status of the parasitized-MEFZ-treated mice compared with parasitized-untreated mice. MEFZ was tolerable up to 5000 mg/kg b.w dose; hence, the LD50 is above 5000 mg/kg b.w. Discussion and conclusions: The results of this curative assay demonstrated that MEFZ has antimalarial effects and normalized haematological and biochemical aberrations generated by malaria. The isolation of the antimalarial principles in MEFZ is warranted; they could be lead molecules for the development of new antimalarials.
format	article
author	Osmund Chukwuma Enechi Christian Chijioke Amah Innocent Uzochukwu Okagu Chidinma Pamela Ononiwu Vitalis Chukwumalume Azidiegwu Eberechukwu Ogochukwu Ugwuoke Amarachukwu Pearl Onoh Emmanuel Elekweuwa Ndukwe
author_facet	Osmund Chukwuma Enechi Christian Chijioke Amah Innocent Uzochukwu Okagu Chidinma Pamela Ononiwu Vitalis Chukwumalume Azidiegwu Eberechukwu Ogochukwu Ugwuoke Amarachukwu Pearl Onoh Emmanuel Elekweuwa Ndukwe
author_sort	Osmund Chukwuma Enechi
title	Methanol extracts of Fagara zanthoxyloides leaves possess antimalarial effects and normalizes haematological and biochemical status of Plasmodium berghei-passaged mice
title_short	Methanol extracts of Fagara zanthoxyloides leaves possess antimalarial effects and normalizes haematological and biochemical status of Plasmodium berghei-passaged mice
title_full	Methanol extracts of Fagara zanthoxyloides leaves possess antimalarial effects and normalizes haematological and biochemical status of Plasmodium berghei-passaged mice
title_fullStr	Methanol extracts of Fagara zanthoxyloides leaves possess antimalarial effects and normalizes haematological and biochemical status of Plasmodium berghei-passaged mice
title_full_unstemmed	Methanol extracts of Fagara zanthoxyloides leaves possess antimalarial effects and normalizes haematological and biochemical status of Plasmodium berghei-passaged mice
title_sort	methanol extracts of fagara zanthoxyloides leaves possess antimalarial effects and normalizes haematological and biochemical status of plasmodium berghei-passaged mice
publisher	Taylor & Francis Group
publishDate	2019
url	https://doaj.org/article/0beb65fcd6c849d681201ae91f62af78
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Methanol extracts of Fagara zanthoxyloides leaves possess antimalarial effects and normalizes haematological and biochemical status of Plasmodium berghei-passaged mice

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