Protective and Therapeutic Effect of Quercetin in Hepatotoxicity Induced by Sepsis in Rats

Septicemia caused by Gram-negative bacteria is an infection associated with liver dysfunction. Quercetin is a natural flavonoid found in vegetables and fruits and has anti-inflammatory, antioxidant, cytoprotective and antiallergic properties. This research aims to investigate the effects of querceti...

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Autores principales:	Mevlüt DOĞUKAN, Murat BIÇAKCIOĞLU, Mehmet DURAN, Zümrüt DOĞAN, Bilge AYDIN TÜRK, Öznur ULUDAĞ
Formato:	article
Lenguaje:	EN
Publicado:	University of Kafkas 2021
Materias:	quercetin sepsis hepatotoxicity rat Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/0bee21e8c0454baca139d008f7de6da3
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spelling	oai:doaj.org-article:0bee21e8c0454baca139d008f7de6da32021-12-03T08:32:49ZProtective and Therapeutic Effect of Quercetin in Hepatotoxicity Induced by Sepsis in Rats10.9775/kvfd.2021.261351300-60451309-2251https://doaj.org/article/0bee21e8c0454baca139d008f7de6da32021-11-01T00:00:00Zhttp://vetdergikafkas.org/uploads/pdf/pdf_KVFD_2862.pdfhttps://doaj.org/toc/1300-6045https://doaj.org/toc/1309-2251Septicemia caused by Gram-negative bacteria is an infection associated with liver dysfunction. Quercetin is a natural flavonoid found in vegetables and fruits and has anti-inflammatory, antioxidant, cytoprotective and antiallergic properties. This research aims to investigate the effects of quercetin on the liver against tissue damage due to sepsis-induced oxidative stress. Thirty-two male rats were used in the study. The animals were randomly divided into 5 groups. Quercetin was dissolved in 20 mg/kg of olive oil daily for 15 days and given through oral gavage. The cecal-ligation sepsis model was applied to the group 3 and group 4. In histopathological evaluation; inflammation involving moderate neutrophils and lymphocytes was observed in most portal areas in the group where sepsis was created (Group 3). In the sepsis group administered quercetin (Group 4) only a few portal areas had a milder inflammation with fewer neutrophils than the sepsis group. There was a significant difference between group 3, 4, and all other groups in ALT and AST values. A significant difference was observed between group 3, 4 and other groups in terms of tissue MDA, GSH levels. It was concluded that quercetin, a powerful antioxidant, can reduce liver damage caused by sepsis and has the potential to be used to help treat sepsis.Mevlüt DOĞUKANMurat BIÇAKCIOĞLUMehmet DURANZümrüt DOĞANBilge AYDIN TÜRKÖznur ULUDAĞUniversity of KafkasarticlequercetinsepsishepatotoxicityratVeterinary medicineSF600-1100ENKafkas Universitesi Veteriner Fakultesi Dergisi, Vol 27, Iss 6, Pp 699-706 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	quercetin sepsis hepatotoxicity rat Veterinary medicine SF600-1100
spellingShingle	quercetin sepsis hepatotoxicity rat Veterinary medicine SF600-1100 Mevlüt DOĞUKAN Murat BIÇAKCIOĞLU Mehmet DURAN Zümrüt DOĞAN Bilge AYDIN TÜRK Öznur ULUDAĞ Protective and Therapeutic Effect of Quercetin in Hepatotoxicity Induced by Sepsis in Rats
description	Septicemia caused by Gram-negative bacteria is an infection associated with liver dysfunction. Quercetin is a natural flavonoid found in vegetables and fruits and has anti-inflammatory, antioxidant, cytoprotective and antiallergic properties. This research aims to investigate the effects of quercetin on the liver against tissue damage due to sepsis-induced oxidative stress. Thirty-two male rats were used in the study. The animals were randomly divided into 5 groups. Quercetin was dissolved in 20 mg/kg of olive oil daily for 15 days and given through oral gavage. The cecal-ligation sepsis model was applied to the group 3 and group 4. In histopathological evaluation; inflammation involving moderate neutrophils and lymphocytes was observed in most portal areas in the group where sepsis was created (Group 3). In the sepsis group administered quercetin (Group 4) only a few portal areas had a milder inflammation with fewer neutrophils than the sepsis group. There was a significant difference between group 3, 4, and all other groups in ALT and AST values. A significant difference was observed between group 3, 4 and other groups in terms of tissue MDA, GSH levels. It was concluded that quercetin, a powerful antioxidant, can reduce liver damage caused by sepsis and has the potential to be used to help treat sepsis.
format	article
author	Mevlüt DOĞUKAN Murat BIÇAKCIOĞLU Mehmet DURAN Zümrüt DOĞAN Bilge AYDIN TÜRK Öznur ULUDAĞ
author_facet	Mevlüt DOĞUKAN Murat BIÇAKCIOĞLU Mehmet DURAN Zümrüt DOĞAN Bilge AYDIN TÜRK Öznur ULUDAĞ
author_sort	Mevlüt DOĞUKAN
title	Protective and Therapeutic Effect of Quercetin in Hepatotoxicity Induced by Sepsis in Rats
title_short	Protective and Therapeutic Effect of Quercetin in Hepatotoxicity Induced by Sepsis in Rats
title_full	Protective and Therapeutic Effect of Quercetin in Hepatotoxicity Induced by Sepsis in Rats
title_fullStr	Protective and Therapeutic Effect of Quercetin in Hepatotoxicity Induced by Sepsis in Rats
title_full_unstemmed	Protective and Therapeutic Effect of Quercetin in Hepatotoxicity Induced by Sepsis in Rats
title_sort	protective and therapeutic effect of quercetin in hepatotoxicity induced by sepsis in rats
publisher	University of Kafkas
publishDate	2021
url	https://doaj.org/article/0bee21e8c0454baca139d008f7de6da3
work_keys_str_mv	AT mevlutdogukan protectiveandtherapeuticeffectofquercetininhepatotoxicityinducedbysepsisinrats AT muratbicakcioglu protectiveandtherapeuticeffectofquercetininhepatotoxicityinducedbysepsisinrats AT mehmetduran protectiveandtherapeuticeffectofquercetininhepatotoxicityinducedbysepsisinrats AT zumrutdogan protectiveandtherapeuticeffectofquercetininhepatotoxicityinducedbysepsisinrats AT bilgeaydinturk protectiveandtherapeuticeffectofquercetininhepatotoxicityinducedbysepsisinrats AT oznuruludag protectiveandtherapeuticeffectofquercetininhepatotoxicityinducedbysepsisinrats
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Protective and Therapeutic Effect of Quercetin in Hepatotoxicity Induced by Sepsis in Rats

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