Double trouble: does co-morbid chronic somatic illness increase risk for recurrence in depression? A systematic review.

<h4>Objective</h4>To perform a systematic review, and if possible a meta-analysis, to establish whether depressed patients with co-morbid chronic somatic illnesses are a high risk "double trouble" group for depressive recurrence.<h4>Method</h4>The databases PubMed,...

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Autores principales:	Gemma D Kok, Claudi L H Bockting, Huibert Burger, Wiebke Hannig, Gerdina H M Pijnenborg, Pim Cuijpers, Steven D Hollon
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0bf4f903d16b427d9105677d7348e4b8
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spelling	oai:doaj.org-article:0bf4f903d16b427d9105677d7348e4b82021-11-18T07:54:57ZDouble trouble: does co-morbid chronic somatic illness increase risk for recurrence in depression? A systematic review.1932-620310.1371/journal.pone.0057510https://doaj.org/article/0bf4f903d16b427d9105677d7348e4b82013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23472087/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>To perform a systematic review, and if possible a meta-analysis, to establish whether depressed patients with co-morbid chronic somatic illnesses are a high risk "double trouble" group for depressive recurrence.<h4>Method</h4>The databases PubMed, EMbase and PsycINFO were systematically searched until the 4(th) of December 2012 by using MeSH and free text terms. Additionally, reference lists of retrieved publications and treatment guidelines were reviewed, and experts were consulted. Inclusion criteria were: depression had to be measured at least twice during the study with qualified instruments and the chronic somatic illness had to be assessed by self-report or by a medical professional. Information on depressive recurrence was extracted and additionally risk ratios of recurrence were calculated.<h4>Results</h4>The search generated four articles that fulfilled our inclusion criteria. These studies showed no differences in recurrence over one- two- three- and 6.5 years of follow-up for a total of 2010 depressed patients of which 694 patients with a co-morbid chronic somatic illness versus 1316 patients without (Study 1: RR = 0.49, 95% CI, 0.17-1.41 at one year follow-up and RR = 1.37, 95% CI, 0.78-2.41 at two year follow-up; Study 2: RR = 0.94, 95% CI, 0.65-1.36 at two year follow-up; Study 3: RR = 1.15, 95% CI, 0.40-3.27 at one year follow-up; RR = 1.07, 95% CI, 0.48-2.42 at two year follow-up and RR = 0.99, 95% CI,0.55-1.77 at 6.5 years follow-up; Study 4: RR = 1.16, 95% CI, 0.86-1.57 at three year follow-up).<h4>Conclusion</h4>We found no association between a heightened risk for depressive recurrence and co-morbid chronic somatic illnesses. There is a need for more longitudinal studies to justify the current specific treatment advice such as long-term pharmacological maintenance treatment for this presumed "double trouble" group.Gemma D KokClaudi L H BocktingHuibert BurgerWiebke HannigGerdina H M PijnenborgPim CuijpersSteven D HollonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e57510 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gemma D Kok Claudi L H Bockting Huibert Burger Wiebke Hannig Gerdina H M Pijnenborg Pim Cuijpers Steven D Hollon Double trouble: does co-morbid chronic somatic illness increase risk for recurrence in depression? A systematic review.
description	<h4>Objective</h4>To perform a systematic review, and if possible a meta-analysis, to establish whether depressed patients with co-morbid chronic somatic illnesses are a high risk "double trouble" group for depressive recurrence.<h4>Method</h4>The databases PubMed, EMbase and PsycINFO were systematically searched until the 4(th) of December 2012 by using MeSH and free text terms. Additionally, reference lists of retrieved publications and treatment guidelines were reviewed, and experts were consulted. Inclusion criteria were: depression had to be measured at least twice during the study with qualified instruments and the chronic somatic illness had to be assessed by self-report or by a medical professional. Information on depressive recurrence was extracted and additionally risk ratios of recurrence were calculated.<h4>Results</h4>The search generated four articles that fulfilled our inclusion criteria. These studies showed no differences in recurrence over one- two- three- and 6.5 years of follow-up for a total of 2010 depressed patients of which 694 patients with a co-morbid chronic somatic illness versus 1316 patients without (Study 1: RR = 0.49, 95% CI, 0.17-1.41 at one year follow-up and RR = 1.37, 95% CI, 0.78-2.41 at two year follow-up; Study 2: RR = 0.94, 95% CI, 0.65-1.36 at two year follow-up; Study 3: RR = 1.15, 95% CI, 0.40-3.27 at one year follow-up; RR = 1.07, 95% CI, 0.48-2.42 at two year follow-up and RR = 0.99, 95% CI,0.55-1.77 at 6.5 years follow-up; Study 4: RR = 1.16, 95% CI, 0.86-1.57 at three year follow-up).<h4>Conclusion</h4>We found no association between a heightened risk for depressive recurrence and co-morbid chronic somatic illnesses. There is a need for more longitudinal studies to justify the current specific treatment advice such as long-term pharmacological maintenance treatment for this presumed "double trouble" group.
format	article
author	Gemma D Kok Claudi L H Bockting Huibert Burger Wiebke Hannig Gerdina H M Pijnenborg Pim Cuijpers Steven D Hollon
author_facet	Gemma D Kok Claudi L H Bockting Huibert Burger Wiebke Hannig Gerdina H M Pijnenborg Pim Cuijpers Steven D Hollon
author_sort	Gemma D Kok
title	Double trouble: does co-morbid chronic somatic illness increase risk for recurrence in depression? A systematic review.
title_short	Double trouble: does co-morbid chronic somatic illness increase risk for recurrence in depression? A systematic review.
title_full	Double trouble: does co-morbid chronic somatic illness increase risk for recurrence in depression? A systematic review.
title_fullStr	Double trouble: does co-morbid chronic somatic illness increase risk for recurrence in depression? A systematic review.
title_full_unstemmed	Double trouble: does co-morbid chronic somatic illness increase risk for recurrence in depression? A systematic review.
title_sort	double trouble: does co-morbid chronic somatic illness increase risk for recurrence in depression? a systematic review.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/0bf4f903d16b427d9105677d7348e4b8
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Double trouble: does co-morbid chronic somatic illness increase risk for recurrence in depression? A systematic review.

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