Impact of estrogen therapy on temporomandibular joints of rats: Histological and hormone analytical study

Objectives: This research aims to evaluate the effects of estrogen deficiency and replacement on the TMJ structures of rats. The considerable similarities in the anatomical features of rats and humans make rats a suitable model for human scientific studies. Methods: A clinical trial was conducted on...

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Autores principales:	Abrar Abdrabuh, Kamilya Baljon, Yagoub Alyami
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	TMJ Temporomandibular joint Estrogen Ovariectomy Temporomandibular disorder Medicine R Dentistry RK1-715
Acceso en línea:	https://doaj.org/article/0bf81c448c6147338338fa59accf26b7
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spelling	oai:doaj.org-article:0bf81c448c6147338338fa59accf26b72021-11-10T04:19:10ZImpact of estrogen therapy on temporomandibular joints of rats: Histological and hormone analytical study1013-905210.1016/j.sdentj.2020.07.006https://doaj.org/article/0bf81c448c6147338338fa59accf26b72021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1013905220307471https://doaj.org/toc/1013-9052Objectives: This research aims to evaluate the effects of estrogen deficiency and replacement on the TMJ structures of rats. The considerable similarities in the anatomical features of rats and humans make rats a suitable model for human scientific studies. Methods: A clinical trial was conducted on 18 female Sprague-Dawley rats grouped into three categories. The GI group included 6 female rats labelled as the control group, the GII group consisted of 6 females that received ovariectomies, and the GIII group had 6 ovariectomised females that were injected with estrogen replacement therapy in a science laboratory at King Abdulaziz University. ANOVA and Tukey HSD post hoc tests were used to determine any significant differences between the levels of estrogen among the three groups. Results: The results indicate that some TMJ structures, including the articular disc and condylar cartilaginous layer, were degraded after estrogen deficiency. However, there was a slight improvement in the cartilaginous layer thickness and proliferation of chondroid cells after estrogen replacement therapy. Estrogen level was reduced in the ovariectomized rats, and while estrogen injections increased blood hormone levels, the levels did not reach those of the control group. Conclusion: Estrogen deficiency degraded some TMJ structures, and there is only a slight recovery after estrogen replacement therapy.Abrar AbdrabuhKamilya BaljonYagoub AlyamiElsevierarticleTMJTemporomandibular jointEstrogenOvariectomyTemporomandibular disorderMedicineRDentistryRK1-715ENSaudi Dental Journal, Vol 33, Iss 7, Pp 608-613 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	TMJ Temporomandibular joint Estrogen Ovariectomy Temporomandibular disorder Medicine R Dentistry RK1-715
spellingShingle	TMJ Temporomandibular joint Estrogen Ovariectomy Temporomandibular disorder Medicine R Dentistry RK1-715 Abrar Abdrabuh Kamilya Baljon Yagoub Alyami Impact of estrogen therapy on temporomandibular joints of rats: Histological and hormone analytical study
description	Objectives: This research aims to evaluate the effects of estrogen deficiency and replacement on the TMJ structures of rats. The considerable similarities in the anatomical features of rats and humans make rats a suitable model for human scientific studies. Methods: A clinical trial was conducted on 18 female Sprague-Dawley rats grouped into three categories. The GI group included 6 female rats labelled as the control group, the GII group consisted of 6 females that received ovariectomies, and the GIII group had 6 ovariectomised females that were injected with estrogen replacement therapy in a science laboratory at King Abdulaziz University. ANOVA and Tukey HSD post hoc tests were used to determine any significant differences between the levels of estrogen among the three groups. Results: The results indicate that some TMJ structures, including the articular disc and condylar cartilaginous layer, were degraded after estrogen deficiency. However, there was a slight improvement in the cartilaginous layer thickness and proliferation of chondroid cells after estrogen replacement therapy. Estrogen level was reduced in the ovariectomized rats, and while estrogen injections increased blood hormone levels, the levels did not reach those of the control group. Conclusion: Estrogen deficiency degraded some TMJ structures, and there is only a slight recovery after estrogen replacement therapy.
format	article
author	Abrar Abdrabuh Kamilya Baljon Yagoub Alyami
author_facet	Abrar Abdrabuh Kamilya Baljon Yagoub Alyami
author_sort	Abrar Abdrabuh
title	Impact of estrogen therapy on temporomandibular joints of rats: Histological and hormone analytical study
title_short	Impact of estrogen therapy on temporomandibular joints of rats: Histological and hormone analytical study
title_full	Impact of estrogen therapy on temporomandibular joints of rats: Histological and hormone analytical study
title_fullStr	Impact of estrogen therapy on temporomandibular joints of rats: Histological and hormone analytical study
title_full_unstemmed	Impact of estrogen therapy on temporomandibular joints of rats: Histological and hormone analytical study
title_sort	impact of estrogen therapy on temporomandibular joints of rats: histological and hormone analytical study
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/0bf81c448c6147338338fa59accf26b7
work_keys_str_mv	AT abrarabdrabuh impactofestrogentherapyontemporomandibularjointsofratshistologicalandhormoneanalyticalstudy AT kamilyabaljon impactofestrogentherapyontemporomandibularjointsofratshistologicalandhormoneanalyticalstudy AT yagoubalyami impactofestrogentherapyontemporomandibularjointsofratshistologicalandhormoneanalyticalstudy
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Impact of estrogen therapy on temporomandibular joints of rats: Histological and hormone analytical study

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