The Effect of Streptozotocin-Induced Chronic Hyperglycemia on Respiratory Effects of Morphine in Rats

BACKGROUND AND OBJECTIVE: Neuropathic pain is a common complication of diabetes. Today opioid analgesics such as morphine, use for the management of neuropathic pain. Since the respiratory effects of morphine have not been studied in diabetes, the aim of this study was to investigate the effect of c...

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Autores principales:	S Pazhoohan, A Alimoradian
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2020
Materias:	diabetes breathing pattern morphine respiratory system. Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0bf8ca5874004aa2aa1b1775e0d530b0
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spelling	oai:doaj.org-article:0bf8ca5874004aa2aa1b1775e0d530b02021-11-09T10:15:54ZThe Effect of Streptozotocin-Induced Chronic Hyperglycemia on Respiratory Effects of Morphine in Rats1561-41072251-7170https://doaj.org/article/0bf8ca5874004aa2aa1b1775e0d530b02020-03-01T00:00:00Zhttp://jbums.org/article-1-8885-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Neuropathic pain is a common complication of diabetes. Today opioid analgesics such as morphine, use for the management of neuropathic pain. Since the respiratory effects of morphine have not been studied in diabetes, the aim of this study was to investigate the effect of chronic hyperglycemia on the effects of morphine on respiration. METHODS: 32 Male Wister rats were randomly allocated into control group (injection of citrate buffer as streptozotocin solvent), morphine group (injection of citrate buffer as STZ solvent and injection of morphine before respiratory recording) group, hyperglycemia group (STZ injection), and hyperglycemia-morphine group (STZ injection and morphine injection before respiratory recording). Hyperglycemia was induced by injecting streptozotocin (35 mg/kg, i.p.). Respiration was recorded by plethysmography after which respiratory volume, inter-breath interval, and respiratory rate were quantified using MATLAB. FINDINGS: Mean of respiratory rate (in the hyperglycemia was 83±3.9 and control was 101±4 (p<0.05)), coefficient of variation of respiratory rates (in the hyperglycemia was 0.615±0.1 and control was 1.05±0.07 (p<0.05)), mean of respiratory volume (in the hyperglycemia was 1.44±0.19 and was control 1.1±0.11 (p<0.05)), and mean of inter-breath interval (in the hyperglycemia was 1.28±0.01 and control was 0.93±0.03 (p<0.05)). coefficient of variation of respiratory volumes (in the hyperglycemia-morphine was 1.14±0.16 and was morphine was 1.68±0.1 (p<0.05)), mean of respiratory rate (in the hyperglycemia-morphine was 1.24±0.34 and morphine was 0.37±0.04 (p<0.05)), and mean of inter-breath interval (in the hyperglycemia-morphine was 1.09±0.07 and morphine was 0.74±0.05 (p<0.01)). CONCLUSION: Our results show that chronic hyperglycemic changed breathing pattern and respiratory response to morphine.S PazhoohanA AlimoradianBabol University of Medical Sciencesarticlediabetesbreathing patternmorphinerespiratory system.MedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 22, Iss 1, Pp 188-194 (2020)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	diabetes breathing pattern morphine respiratory system. Medicine R Medicine (General) R5-920
spellingShingle	diabetes breathing pattern morphine respiratory system. Medicine R Medicine (General) R5-920 S Pazhoohan A Alimoradian The Effect of Streptozotocin-Induced Chronic Hyperglycemia on Respiratory Effects of Morphine in Rats
description	BACKGROUND AND OBJECTIVE: Neuropathic pain is a common complication of diabetes. Today opioid analgesics such as morphine, use for the management of neuropathic pain. Since the respiratory effects of morphine have not been studied in diabetes, the aim of this study was to investigate the effect of chronic hyperglycemia on the effects of morphine on respiration. METHODS: 32 Male Wister rats were randomly allocated into control group (injection of citrate buffer as streptozotocin solvent), morphine group (injection of citrate buffer as STZ solvent and injection of morphine before respiratory recording) group, hyperglycemia group (STZ injection), and hyperglycemia-morphine group (STZ injection and morphine injection before respiratory recording). Hyperglycemia was induced by injecting streptozotocin (35 mg/kg, i.p.). Respiration was recorded by plethysmography after which respiratory volume, inter-breath interval, and respiratory rate were quantified using MATLAB. FINDINGS: Mean of respiratory rate (in the hyperglycemia was 83±3.9 and control was 101±4 (p<0.05)), coefficient of variation of respiratory rates (in the hyperglycemia was 0.615±0.1 and control was 1.05±0.07 (p<0.05)), mean of respiratory volume (in the hyperglycemia was 1.44±0.19 and was control 1.1±0.11 (p<0.05)), and mean of inter-breath interval (in the hyperglycemia was 1.28±0.01 and control was 0.93±0.03 (p<0.05)). coefficient of variation of respiratory volumes (in the hyperglycemia-morphine was 1.14±0.16 and was morphine was 1.68±0.1 (p<0.05)), mean of respiratory rate (in the hyperglycemia-morphine was 1.24±0.34 and morphine was 0.37±0.04 (p<0.05)), and mean of inter-breath interval (in the hyperglycemia-morphine was 1.09±0.07 and morphine was 0.74±0.05 (p<0.01)). CONCLUSION: Our results show that chronic hyperglycemic changed breathing pattern and respiratory response to morphine.
format	article
author	S Pazhoohan A Alimoradian
author_facet	S Pazhoohan A Alimoradian
author_sort	S Pazhoohan
title	The Effect of Streptozotocin-Induced Chronic Hyperglycemia on Respiratory Effects of Morphine in Rats
title_short	The Effect of Streptozotocin-Induced Chronic Hyperglycemia on Respiratory Effects of Morphine in Rats
title_full	The Effect of Streptozotocin-Induced Chronic Hyperglycemia on Respiratory Effects of Morphine in Rats
title_fullStr	The Effect of Streptozotocin-Induced Chronic Hyperglycemia on Respiratory Effects of Morphine in Rats
title_full_unstemmed	The Effect of Streptozotocin-Induced Chronic Hyperglycemia on Respiratory Effects of Morphine in Rats
title_sort	effect of streptozotocin-induced chronic hyperglycemia on respiratory effects of morphine in rats
publisher	Babol University of Medical Sciences
publishDate	2020
url	https://doaj.org/article/0bf8ca5874004aa2aa1b1775e0d530b0
work_keys_str_mv	AT spazhoohan theeffectofstreptozotocininducedchronichyperglycemiaonrespiratoryeffectsofmorphineinrats AT aalimoradian theeffectofstreptozotocininducedchronichyperglycemiaonrespiratoryeffectsofmorphineinrats AT spazhoohan effectofstreptozotocininducedchronichyperglycemiaonrespiratoryeffectsofmorphineinrats AT aalimoradian effectofstreptozotocininducedchronichyperglycemiaonrespiratoryeffectsofmorphineinrats
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The Effect of Streptozotocin-Induced Chronic Hyperglycemia on Respiratory Effects of Morphine in Rats

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