Glutamic acid is a carrier for hydrazine during the biosyntheses of fosfazinomycin and kinamycin

The natural products fosfazinomycin A and kinamycin D are structurally distinct except for a nitrogen-nitrogen (N-N) bond. Here, the authors show that fosfazinomycin and kinamycin share a common pathway for N-N bond formation that is different from pathways found for other natural products.

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Autores principales: Kwo-Kwang A. Wang, Tai L. Ng, Peng Wang, Zedu Huang, Emily P. Balskus, Wilfred A. van der Donk
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/0bfcbb1345f341b6b1521cc37c83a8a0
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