Dynamic local connectivity uncovers altered brain synchrony during propofol sedation

Abstract Human consciousness is considered a result of the synchronous “humming” of multiple dynamic networks. We performed a dynamic functional connectivity analysis using resting state functional magnetic resonance imaging (rsfMRI) in 14 patients before and during a propofol infusion to characteri...

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Autores principales:	Rose Dawn Bharath, Rajanikant Panda, Jitender Saini, Kamath Sriganesh, G. S. Umamaheswara Rao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0bfd2900f7724b85a39117f7c520155d
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spelling	oai:doaj.org-article:0bfd2900f7724b85a39117f7c520155d2021-12-02T16:06:45ZDynamic local connectivity uncovers altered brain synchrony during propofol sedation10.1038/s41598-017-08135-22045-2322https://doaj.org/article/0bfd2900f7724b85a39117f7c520155d2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08135-2https://doaj.org/toc/2045-2322Abstract Human consciousness is considered a result of the synchronous “humming” of multiple dynamic networks. We performed a dynamic functional connectivity analysis using resting state functional magnetic resonance imaging (rsfMRI) in 14 patients before and during a propofol infusion to characterize the sedation-induced alterations in consciousness. A sliding 36-second window was used to derive 59 time points of whole brain integrated local connectivity measurements. Significant changes in the connectivity strength (Z Corr) at various time points were used to measure the connectivity fluctuations during awake and sedated states. Compared with the awake state, sedation was associated with reduced cortical connectivity fluctuations in several areas connected to the default mode network and around the perirolandic cortex with a significantly decreased correlation of connectivity between their anatomical homologues. In addition, sedation was associated with increased connectivity fluctuations in the frequency range of 0.027 to 0.063 Hz in several deep nuclear regions, including the cerebellum, thalamus, basal ganglia and insula. These findings advance our understanding of sedation-induced altered consciousness by visualizing the altered dynamics in several cortical and subcortical regions and support the concept of defining consciousness as a dynamic and integrated network.Rose Dawn BharathRajanikant PandaJitender SainiKamath SriganeshG. S. Umamaheswara RaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rose Dawn Bharath Rajanikant Panda Jitender Saini Kamath Sriganesh G. S. Umamaheswara Rao Dynamic local connectivity uncovers altered brain synchrony during propofol sedation
description	Abstract Human consciousness is considered a result of the synchronous “humming” of multiple dynamic networks. We performed a dynamic functional connectivity analysis using resting state functional magnetic resonance imaging (rsfMRI) in 14 patients before and during a propofol infusion to characterize the sedation-induced alterations in consciousness. A sliding 36-second window was used to derive 59 time points of whole brain integrated local connectivity measurements. Significant changes in the connectivity strength (Z Corr) at various time points were used to measure the connectivity fluctuations during awake and sedated states. Compared with the awake state, sedation was associated with reduced cortical connectivity fluctuations in several areas connected to the default mode network and around the perirolandic cortex with a significantly decreased correlation of connectivity between their anatomical homologues. In addition, sedation was associated with increased connectivity fluctuations in the frequency range of 0.027 to 0.063 Hz in several deep nuclear regions, including the cerebellum, thalamus, basal ganglia and insula. These findings advance our understanding of sedation-induced altered consciousness by visualizing the altered dynamics in several cortical and subcortical regions and support the concept of defining consciousness as a dynamic and integrated network.
format	article
author	Rose Dawn Bharath Rajanikant Panda Jitender Saini Kamath Sriganesh G. S. Umamaheswara Rao
author_facet	Rose Dawn Bharath Rajanikant Panda Jitender Saini Kamath Sriganesh G. S. Umamaheswara Rao
author_sort	Rose Dawn Bharath
title	Dynamic local connectivity uncovers altered brain synchrony during propofol sedation
title_short	Dynamic local connectivity uncovers altered brain synchrony during propofol sedation
title_full	Dynamic local connectivity uncovers altered brain synchrony during propofol sedation
title_fullStr	Dynamic local connectivity uncovers altered brain synchrony during propofol sedation
title_full_unstemmed	Dynamic local connectivity uncovers altered brain synchrony during propofol sedation
title_sort	dynamic local connectivity uncovers altered brain synchrony during propofol sedation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0bfd2900f7724b85a39117f7c520155d
work_keys_str_mv	AT rosedawnbharath dynamiclocalconnectivityuncoversalteredbrainsynchronyduringpropofolsedation AT rajanikantpanda dynamiclocalconnectivityuncoversalteredbrainsynchronyduringpropofolsedation AT jitendersaini dynamiclocalconnectivityuncoversalteredbrainsynchronyduringpropofolsedation AT kamathsriganesh dynamiclocalconnectivityuncoversalteredbrainsynchronyduringpropofolsedation AT gsumamaheswararao dynamiclocalconnectivityuncoversalteredbrainsynchronyduringpropofolsedation
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Dynamic local connectivity uncovers altered brain synchrony during propofol sedation

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