Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer’s disease

Dopaminergic dysfunction occurs in Alzheimer’s disease (AD). The authors show that in a mouse model of AD, loss of dopaminergic neurons in the ventral tegmental area, but not the substantia nigra, occurs at early pre-plaque stages, and may contribute to impaired cognition and reward processing.

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Autores principales:	Annalisa Nobili, Emanuele Claudio Latagliata, Maria Teresa Viscomi, Virve Cavallucci, Debora Cutuli, Giacomo Giacovazzo, Paraskevi Krashia, Francesca Romana Rizzo, Ramona Marino, Mauro Federici, Paola De Bartolo, Daniela Aversa, Maria Concetta Dell’Acqua, Alberto Cordella, Marco Sancandi, Flavio Keller, Laura Petrosini, Stefano Puglisi-Allegra, Nicola Biagio Mercuri, Roberto Coccurello, Nicola Berretta, Marcello D’Amelio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0bfe3928a258483cb4eba1b96c8e6f16
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spelling	oai:doaj.org-article:0bfe3928a258483cb4eba1b96c8e6f162021-12-02T17:06:19ZDopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer’s disease10.1038/ncomms147272041-1723https://doaj.org/article/0bfe3928a258483cb4eba1b96c8e6f162017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms14727https://doaj.org/toc/2041-1723Dopaminergic dysfunction occurs in Alzheimer’s disease (AD). The authors show that in a mouse model of AD, loss of dopaminergic neurons in the ventral tegmental area, but not the substantia nigra, occurs at early pre-plaque stages, and may contribute to impaired cognition and reward processing.Annalisa NobiliEmanuele Claudio LatagliataMaria Teresa ViscomiVirve CavallucciDebora CutuliGiacomo GiacovazzoParaskevi KrashiaFrancesca Romana RizzoRamona MarinoMauro FedericiPaola De BartoloDaniela AversaMaria Concetta Dell’AcquaAlberto CordellaMarco SancandiFlavio KellerLaura PetrosiniStefano Puglisi-AllegraNicola Biagio MercuriRoberto CoccurelloNicola BerrettaMarcello D’AmelioNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Annalisa Nobili Emanuele Claudio Latagliata Maria Teresa Viscomi Virve Cavallucci Debora Cutuli Giacomo Giacovazzo Paraskevi Krashia Francesca Romana Rizzo Ramona Marino Mauro Federici Paola De Bartolo Daniela Aversa Maria Concetta Dell’Acqua Alberto Cordella Marco Sancandi Flavio Keller Laura Petrosini Stefano Puglisi-Allegra Nicola Biagio Mercuri Roberto Coccurello Nicola Berretta Marcello D’Amelio Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer’s disease
description	Dopaminergic dysfunction occurs in Alzheimer’s disease (AD). The authors show that in a mouse model of AD, loss of dopaminergic neurons in the ventral tegmental area, but not the substantia nigra, occurs at early pre-plaque stages, and may contribute to impaired cognition and reward processing.
format	article
author	Annalisa Nobili Emanuele Claudio Latagliata Maria Teresa Viscomi Virve Cavallucci Debora Cutuli Giacomo Giacovazzo Paraskevi Krashia Francesca Romana Rizzo Ramona Marino Mauro Federici Paola De Bartolo Daniela Aversa Maria Concetta Dell’Acqua Alberto Cordella Marco Sancandi Flavio Keller Laura Petrosini Stefano Puglisi-Allegra Nicola Biagio Mercuri Roberto Coccurello Nicola Berretta Marcello D’Amelio
author_facet	Annalisa Nobili Emanuele Claudio Latagliata Maria Teresa Viscomi Virve Cavallucci Debora Cutuli Giacomo Giacovazzo Paraskevi Krashia Francesca Romana Rizzo Ramona Marino Mauro Federici Paola De Bartolo Daniela Aversa Maria Concetta Dell’Acqua Alberto Cordella Marco Sancandi Flavio Keller Laura Petrosini Stefano Puglisi-Allegra Nicola Biagio Mercuri Roberto Coccurello Nicola Berretta Marcello D’Amelio
author_sort	Annalisa Nobili
title	Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer’s disease
title_short	Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer’s disease
title_full	Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer’s disease
title_fullStr	Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer’s disease
title_full_unstemmed	Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer’s disease
title_sort	dopamine neuronal loss contributes to memory and reward dysfunction in a model of alzheimer’s disease
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0bfe3928a258483cb4eba1b96c8e6f16
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Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer’s disease

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