Transmission is a Noticeable Cause of Resistance Among Treated Tuberculosis Patients in Shanghai, China

Abstract It is generally believed that drug resistance among treated tuberculosis (TB) patients is as a result of acquired drug resistance due to inappropriate treatment. Previous studies have shown that primary drug resistance caused by transmission also plays a role among treated cases. Differenti...

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Autores principales:	Chijioke A. Nsofor, Qi Jiang, Jie Wu, Mingyu Gan, Qingyun Liu, Tianyu Zuo, Guofeng Zhu, Qian Gao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0bfee3802d514a38a9357a928a8014be
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spelling	oai:doaj.org-article:0bfee3802d514a38a9357a928a8014be2021-12-02T15:06:14ZTransmission is a Noticeable Cause of Resistance Among Treated Tuberculosis Patients in Shanghai, China10.1038/s41598-017-08061-32045-2322https://doaj.org/article/0bfee3802d514a38a9357a928a8014be2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08061-3https://doaj.org/toc/2045-2322Abstract It is generally believed that drug resistance among treated tuberculosis (TB) patients is as a result of acquired drug resistance due to inappropriate treatment. Previous studies have shown that primary drug resistance caused by transmission also plays a role among treated cases. Differentiating the two types of drug resistance will help in developing appropriate strategies for control of drug resistant tuberculosis. In this study, we tested the hypothesis that drug resistance among treated TB patients is mainly caused by primary resistance rather than acquired resistance. Defining resistance profiles by molecular drug susceptibility test, we used Unit Variable Number Tandem Repeats (VNTR) to genotype and Whole Genome Sequencing (WGS) to confirm the accordance of the first and last Mycobacterium tuberculosis isolates from treated pulmonary TB patients in Shanghai from 2009–2015. Among 81 patients with increasing drug resistance, out of 390 patients enrolled, paired isolates from 59.3% (48/81) had different VNTR patterns indicating primary drug resistance. Our results have demonstrated that primary resistance due to exogenous reinfection is the major cause of drug resistance among treated TB patients in Shanghai; thus, strategies aimed at preventing and interrupting transmission are urgently needed to effectively reduce the epidemic of drug resistant tuberculosis.Chijioke A. NsoforQi JiangJie WuMingyu GanQingyun LiuTianyu ZuoGuofeng ZhuQian GaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chijioke A. Nsofor Qi Jiang Jie Wu Mingyu Gan Qingyun Liu Tianyu Zuo Guofeng Zhu Qian Gao Transmission is a Noticeable Cause of Resistance Among Treated Tuberculosis Patients in Shanghai, China
description	Abstract It is generally believed that drug resistance among treated tuberculosis (TB) patients is as a result of acquired drug resistance due to inappropriate treatment. Previous studies have shown that primary drug resistance caused by transmission also plays a role among treated cases. Differentiating the two types of drug resistance will help in developing appropriate strategies for control of drug resistant tuberculosis. In this study, we tested the hypothesis that drug resistance among treated TB patients is mainly caused by primary resistance rather than acquired resistance. Defining resistance profiles by molecular drug susceptibility test, we used Unit Variable Number Tandem Repeats (VNTR) to genotype and Whole Genome Sequencing (WGS) to confirm the accordance of the first and last Mycobacterium tuberculosis isolates from treated pulmonary TB patients in Shanghai from 2009–2015. Among 81 patients with increasing drug resistance, out of 390 patients enrolled, paired isolates from 59.3% (48/81) had different VNTR patterns indicating primary drug resistance. Our results have demonstrated that primary resistance due to exogenous reinfection is the major cause of drug resistance among treated TB patients in Shanghai; thus, strategies aimed at preventing and interrupting transmission are urgently needed to effectively reduce the epidemic of drug resistant tuberculosis.
format	article
author	Chijioke A. Nsofor Qi Jiang Jie Wu Mingyu Gan Qingyun Liu Tianyu Zuo Guofeng Zhu Qian Gao
author_facet	Chijioke A. Nsofor Qi Jiang Jie Wu Mingyu Gan Qingyun Liu Tianyu Zuo Guofeng Zhu Qian Gao
author_sort	Chijioke A. Nsofor
title	Transmission is a Noticeable Cause of Resistance Among Treated Tuberculosis Patients in Shanghai, China
title_short	Transmission is a Noticeable Cause of Resistance Among Treated Tuberculosis Patients in Shanghai, China
title_full	Transmission is a Noticeable Cause of Resistance Among Treated Tuberculosis Patients in Shanghai, China
title_fullStr	Transmission is a Noticeable Cause of Resistance Among Treated Tuberculosis Patients in Shanghai, China
title_full_unstemmed	Transmission is a Noticeable Cause of Resistance Among Treated Tuberculosis Patients in Shanghai, China
title_sort	transmission is a noticeable cause of resistance among treated tuberculosis patients in shanghai, china
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0bfee3802d514a38a9357a928a8014be
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Transmission is a Noticeable Cause of Resistance Among Treated Tuberculosis Patients in Shanghai, China

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