Изучение количества циркулирующих прогениторных клеток эндотелия у больных сахарным диабетом 1 типа

Aim. Circulating progenitor endothelial cells (CPCs) play an important role in the regeneration of damaged vascular endothelium. We aimed to study the effect of type 1 diabetes mellitus (DM) on the number of different lines of CPCs.Methods. The number of different lines of CPCs was evaluated by flow...

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Autores principales:	Angelina Valerievna Sokolova, Tatyana Nikolaevna Kochegura, Elena Viktorovna Parfyonova, Marina Vladimirovna Shestakova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2015
Materias:	circulating progenitor cells diabetes mellitus 1 type disfunction of endothelium Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/0bff0004d58a495ea14a56f7ef8adad9
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spelling	oai:doaj.org-article:0bff0004d58a495ea14a56f7ef8adad92021-11-14T09:00:19ZИзучение количества циркулирующих прогениторных клеток эндотелия у больных сахарным диабетом 1 типа2072-03512072-037810.14341/DM2015351-56https://doaj.org/article/0bff0004d58a495ea14a56f7ef8adad92015-10-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/7185https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. Circulating progenitor endothelial cells (CPCs) play an important role in the regeneration of damaged vascular endothelium. We aimed to study the effect of type 1 diabetes mellitus (DM) on the number of different lines of CPCs.Methods. The number of different lines of CPCs was evaluated by flow cytometry in 45 patients with type 1 DM (mean age: 26,6±6,5 years) of different duration and 14 healthy volunteers.Results. The number of CPCs in the peripheral blood flow of patients with type 1 DM was significanlty reduced compared with that in healthy volunteers and had a reliable inverse correlation with glycated haemoglobin (HbA1c).Conclusions. The number of CPCs in the peripheral blood flow of patients with type 1 DM depended on the level of DM compensation. Of the different lines of CPCs, Lin-CD34+ cells were significantly reduced by 42% (p=0,006), Lin-CD34+c-Kit- cells by 42% (p=0,007) and Lin-CD34+c-Kit+ cells by 41% (p=0,022). Thus, the number of CPCs in the peripheral blood of patients with type 1 DM is reduced with higher levels of HbA1c.Angelina Valerievna SokolovaTatyana Nikolaevna KocheguraElena Viktorovna ParfyonovaMarina Vladimirovna ShestakovaEndocrinology Research Centrearticlecirculating progenitor cellsdiabetes mellitus 1 typedisfunction of endotheliumNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 18, Iss 3, Pp 51-56 (2015)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	circulating progenitor cells diabetes mellitus 1 type disfunction of endothelium Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	circulating progenitor cells diabetes mellitus 1 type disfunction of endothelium Nutritional diseases. Deficiency diseases RC620-627 Angelina Valerievna Sokolova Tatyana Nikolaevna Kochegura Elena Viktorovna Parfyonova Marina Vladimirovna Shestakova Изучение количества циркулирующих прогениторных клеток эндотелия у больных сахарным диабетом 1 типа
description	Aim. Circulating progenitor endothelial cells (CPCs) play an important role in the regeneration of damaged vascular endothelium. We aimed to study the effect of type 1 diabetes mellitus (DM) on the number of different lines of CPCs.Methods. The number of different lines of CPCs was evaluated by flow cytometry in 45 patients with type 1 DM (mean age: 26,6±6,5 years) of different duration and 14 healthy volunteers.Results. The number of CPCs in the peripheral blood flow of patients with type 1 DM was significanlty reduced compared with that in healthy volunteers and had a reliable inverse correlation with glycated haemoglobin (HbA1c).Conclusions. The number of CPCs in the peripheral blood flow of patients with type 1 DM depended on the level of DM compensation. Of the different lines of CPCs, Lin-CD34+ cells were significantly reduced by 42% (p=0,006), Lin-CD34+c-Kit- cells by 42% (p=0,007) and Lin-CD34+c-Kit+ cells by 41% (p=0,022). Thus, the number of CPCs in the peripheral blood of patients with type 1 DM is reduced with higher levels of HbA1c.
format	article
author	Angelina Valerievna Sokolova Tatyana Nikolaevna Kochegura Elena Viktorovna Parfyonova Marina Vladimirovna Shestakova
author_facet	Angelina Valerievna Sokolova Tatyana Nikolaevna Kochegura Elena Viktorovna Parfyonova Marina Vladimirovna Shestakova
author_sort	Angelina Valerievna Sokolova
title	Изучение количества циркулирующих прогениторных клеток эндотелия у больных сахарным диабетом 1 типа
title_short	Изучение количества циркулирующих прогениторных клеток эндотелия у больных сахарным диабетом 1 типа
title_full	Изучение количества циркулирующих прогениторных клеток эндотелия у больных сахарным диабетом 1 типа
title_fullStr	Изучение количества циркулирующих прогениторных клеток эндотелия у больных сахарным диабетом 1 типа
title_full_unstemmed	Изучение количества циркулирующих прогениторных клеток эндотелия у больных сахарным диабетом 1 типа
title_sort	изучение количества циркулирующих прогениторных клеток эндотелия у больных сахарным диабетом 1 типа
publisher	Endocrinology Research Centre
publishDate	2015
url	https://doaj.org/article/0bff0004d58a495ea14a56f7ef8adad9
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Изучение количества циркулирующих прогениторных клеток эндотелия у больных сахарным диабетом 1 типа

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