Genome-wide CRISPR interference screen identifies long non-coding RNA loci required for differentiation and pluripotency.

Genome-wide CRISPR interference screen identifies long non-coding RNA loci required for differentiation and pluripotency.

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Although many long non-coding RNAs (lncRNAs) exhibit lineage-specific expression, the vast majority remain functionally uncharacterized in the context of development. Here, we report the first described human embryonic stem cell (hESC) lines to repress (CRISPRi) or activate (CRISPRa) transcription d...

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Autores principales: Jeffrey R Haswell, Kaia Mattioli, Chiara Gerhardinger, Philipp G Maass, Daniel J Foster, Paola Peinado, Xiaofeng Wang, Pedro P Medina, John L Rinn, Frank J Slack
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/0c003e912f964144b90286b77f64afc5
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