Acyl coenzyme A synthetase long-chain 1 (ACSL1) gene polymorphism (rs6552828) and elite endurance athletic status: a replication study.

The aim of this study was to determine the association between the rs6552828 polymorphism in acyl coenzyme A synthetase (ACSL1) and elite endurance athletic status. We studied 82 Caucasian (Spanish) World/Olympic-class endurance male athletes, and a group of sex and ethnically matched healthy young...

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Autores principales:	Thomas Yvert, Zi-Hong He, Catalina Santiago, Yang Hu, Yan-Chun Li, Félix Gómez-Gallego, Carmen Fiuza-Luces, Zoraida Verde, Carlos A Muniesa, Jesús Oliván, Alfredo Santalla, Jonatan R Ruiz, Alejandro Lucia
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0c005d432c7348ae8f803408f15a9bbd
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spelling	oai:doaj.org-article:0c005d432c7348ae8f803408f15a9bbd2021-11-18T07:11:48ZAcyl coenzyme A synthetase long-chain 1 (ACSL1) gene polymorphism (rs6552828) and elite endurance athletic status: a replication study.1932-620310.1371/journal.pone.0041268https://doaj.org/article/0c005d432c7348ae8f803408f15a9bbd2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22829935/?tool=EBIhttps://doaj.org/toc/1932-6203The aim of this study was to determine the association between the rs6552828 polymorphism in acyl coenzyme A synthetase (ACSL1) and elite endurance athletic status. We studied 82 Caucasian (Spanish) World/Olympic-class endurance male athletes, and a group of sex and ethnically matched healthy young adults (controls, n=197). The analyses were replicated in a cohort of a different ethnic origin (Chinese of the Han ethnic group), composed of elite endurance athletes (runners) [cases, n=241 (128 male)] and healthy sedentary adults [controls, n=504 (267 male)]. In the Spanish cohort, genotype (P=0.591) and minor allele (A) frequencies were similar in cases and controls (P=0.978). In the Chinese cohort, genotype (P=0.973) and minor allele (G) frequencies were comparable in female endurance athletes and sedentary controls (P=0.881), whereas in males the frequency of the G allele was higher in endurance athletes (0.40) compared with their controls (0.32, P=0.040). The odds ratio (95%CI) for an elite endurance Chinese athlete to carry the G allele compared with ethnically matched controls was 1.381 (1.015-1.880) (P-value=0.04). Our findings suggest that the ACSL1 gene polymorphism rs6552828 is not associated with elite endurance athletic status in Caucasians, yet a marginal association seems to exist for the Chinese (Han) male population.Thomas YvertZi-Hong HeCatalina SantiagoYang HuYan-Chun LiFélix Gómez-GallegoCarmen Fiuza-LucesZoraida VerdeCarlos A MuniesaJesús OlivánAlfredo SantallaJonatan R RuizAlejandro LuciaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 7, p e41268 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Thomas Yvert Zi-Hong He Catalina Santiago Yang Hu Yan-Chun Li Félix Gómez-Gallego Carmen Fiuza-Luces Zoraida Verde Carlos A Muniesa Jesús Oliván Alfredo Santalla Jonatan R Ruiz Alejandro Lucia Acyl coenzyme A synthetase long-chain 1 (ACSL1) gene polymorphism (rs6552828) and elite endurance athletic status: a replication study.
description	The aim of this study was to determine the association between the rs6552828 polymorphism in acyl coenzyme A synthetase (ACSL1) and elite endurance athletic status. We studied 82 Caucasian (Spanish) World/Olympic-class endurance male athletes, and a group of sex and ethnically matched healthy young adults (controls, n=197). The analyses were replicated in a cohort of a different ethnic origin (Chinese of the Han ethnic group), composed of elite endurance athletes (runners) [cases, n=241 (128 male)] and healthy sedentary adults [controls, n=504 (267 male)]. In the Spanish cohort, genotype (P=0.591) and minor allele (A) frequencies were similar in cases and controls (P=0.978). In the Chinese cohort, genotype (P=0.973) and minor allele (G) frequencies were comparable in female endurance athletes and sedentary controls (P=0.881), whereas in males the frequency of the G allele was higher in endurance athletes (0.40) compared with their controls (0.32, P=0.040). The odds ratio (95%CI) for an elite endurance Chinese athlete to carry the G allele compared with ethnically matched controls was 1.381 (1.015-1.880) (P-value=0.04). Our findings suggest that the ACSL1 gene polymorphism rs6552828 is not associated with elite endurance athletic status in Caucasians, yet a marginal association seems to exist for the Chinese (Han) male population.
format	article
author	Thomas Yvert Zi-Hong He Catalina Santiago Yang Hu Yan-Chun Li Félix Gómez-Gallego Carmen Fiuza-Luces Zoraida Verde Carlos A Muniesa Jesús Oliván Alfredo Santalla Jonatan R Ruiz Alejandro Lucia
author_facet	Thomas Yvert Zi-Hong He Catalina Santiago Yang Hu Yan-Chun Li Félix Gómez-Gallego Carmen Fiuza-Luces Zoraida Verde Carlos A Muniesa Jesús Oliván Alfredo Santalla Jonatan R Ruiz Alejandro Lucia
author_sort	Thomas Yvert
title	Acyl coenzyme A synthetase long-chain 1 (ACSL1) gene polymorphism (rs6552828) and elite endurance athletic status: a replication study.
title_short	Acyl coenzyme A synthetase long-chain 1 (ACSL1) gene polymorphism (rs6552828) and elite endurance athletic status: a replication study.
title_full	Acyl coenzyme A synthetase long-chain 1 (ACSL1) gene polymorphism (rs6552828) and elite endurance athletic status: a replication study.
title_fullStr	Acyl coenzyme A synthetase long-chain 1 (ACSL1) gene polymorphism (rs6552828) and elite endurance athletic status: a replication study.
title_full_unstemmed	Acyl coenzyme A synthetase long-chain 1 (ACSL1) gene polymorphism (rs6552828) and elite endurance athletic status: a replication study.
title_sort	acyl coenzyme a synthetase long-chain 1 (acsl1) gene polymorphism (rs6552828) and elite endurance athletic status: a replication study.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/0c005d432c7348ae8f803408f15a9bbd
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Acyl coenzyme A synthetase long-chain 1 (ACSL1) gene polymorphism (rs6552828) and elite endurance athletic status: a replication study.

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