Prevention of Treacher Collins syndrome craniofacial anomalies in mouse models via maternal antioxidant supplementation

The TCOF1 gene is mutated in Treacher Collin's syndrome, a congenital craniofacial syndrome. Here, the authors show that Tcof1loss-of-function results in oxidative stress induced DNA damage and neuroepithelial cell death, and addition of antioxidants to pregnant mutant mice protected against th...

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Autores principales:	Daisuke Sakai, Jill Dixon, Annita Achilleos, Michael Dixon, Paul A. Trainor
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0c06c33ffc524a02843d403e11f7891b
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spelling	oai:doaj.org-article:0c06c33ffc524a02843d403e11f7891b2021-12-02T14:39:51ZPrevention of Treacher Collins syndrome craniofacial anomalies in mouse models via maternal antioxidant supplementation10.1038/ncomms103282041-1723https://doaj.org/article/0c06c33ffc524a02843d403e11f7891b2016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10328https://doaj.org/toc/2041-1723The TCOF1 gene is mutated in Treacher Collin's syndrome, a congenital craniofacial syndrome. Here, the authors show that Tcof1loss-of-function results in oxidative stress induced DNA damage and neuroepithelial cell death, and addition of antioxidants to pregnant mutant mice protected against these defects.Daisuke SakaiJill DixonAnnita AchilleosMichael DixonPaul A. TrainorNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daisuke Sakai Jill Dixon Annita Achilleos Michael Dixon Paul A. Trainor Prevention of Treacher Collins syndrome craniofacial anomalies in mouse models via maternal antioxidant supplementation
description	The TCOF1 gene is mutated in Treacher Collin's syndrome, a congenital craniofacial syndrome. Here, the authors show that Tcof1loss-of-function results in oxidative stress induced DNA damage and neuroepithelial cell death, and addition of antioxidants to pregnant mutant mice protected against these defects.
format	article
author	Daisuke Sakai Jill Dixon Annita Achilleos Michael Dixon Paul A. Trainor
author_facet	Daisuke Sakai Jill Dixon Annita Achilleos Michael Dixon Paul A. Trainor
author_sort	Daisuke Sakai
title	Prevention of Treacher Collins syndrome craniofacial anomalies in mouse models via maternal antioxidant supplementation
title_short	Prevention of Treacher Collins syndrome craniofacial anomalies in mouse models via maternal antioxidant supplementation
title_full	Prevention of Treacher Collins syndrome craniofacial anomalies in mouse models via maternal antioxidant supplementation
title_fullStr	Prevention of Treacher Collins syndrome craniofacial anomalies in mouse models via maternal antioxidant supplementation
title_full_unstemmed	Prevention of Treacher Collins syndrome craniofacial anomalies in mouse models via maternal antioxidant supplementation
title_sort	prevention of treacher collins syndrome craniofacial anomalies in mouse models via maternal antioxidant supplementation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/0c06c33ffc524a02843d403e11f7891b
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Prevention of Treacher Collins syndrome craniofacial anomalies in mouse models via maternal antioxidant supplementation

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