Kindlin-2 mediates mechanotransduction in bone by regulating expression of Sclerostin in osteocytes

Qin et al. show the involvement of Kindlin-2 in osteocyte mechanotransduction. They show Kindlin-2 mediates skeletal responses to mechanical stimulation through Smad 2/3 mediated inhibition of Sclerostin.

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Detalles Bibliográficos
Autores principales:	Lei Qin, Xuekun Fu, Jing Ma, Manxia Lin, Peijun Zhang, Yishu Wang, Qinnan Yan, Chu Tao, Wen Liu, Bin Tang, Di Chen, Xiaochun Bai, Huiling Cao, Guozhi Xiao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/0c081a3580bc408089962eec2ee0cb9b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:0c081a3580bc408089962eec2ee0cb9b2021-12-02T13:24:24ZKindlin-2 mediates mechanotransduction in bone by regulating expression of Sclerostin in osteocytes10.1038/s42003-021-01950-42399-3642https://doaj.org/article/0c081a3580bc408089962eec2ee0cb9b2021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01950-4https://doaj.org/toc/2399-3642Qin et al. show the involvement of Kindlin-2 in osteocyte mechanotransduction. They show Kindlin-2 mediates skeletal responses to mechanical stimulation through Smad 2/3 mediated inhibition of Sclerostin.Lei QinXuekun FuJing MaManxia LinPeijun ZhangYishu WangQinnan YanChu TaoWen LiuBin TangDi ChenXiaochun BaiHuiling CaoGuozhi XiaoNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Lei Qin Xuekun Fu Jing Ma Manxia Lin Peijun Zhang Yishu Wang Qinnan Yan Chu Tao Wen Liu Bin Tang Di Chen Xiaochun Bai Huiling Cao Guozhi Xiao Kindlin-2 mediates mechanotransduction in bone by regulating expression of Sclerostin in osteocytes
description	Qin et al. show the involvement of Kindlin-2 in osteocyte mechanotransduction. They show Kindlin-2 mediates skeletal responses to mechanical stimulation through Smad 2/3 mediated inhibition of Sclerostin.
format	article
author	Lei Qin Xuekun Fu Jing Ma Manxia Lin Peijun Zhang Yishu Wang Qinnan Yan Chu Tao Wen Liu Bin Tang Di Chen Xiaochun Bai Huiling Cao Guozhi Xiao
author_facet	Lei Qin Xuekun Fu Jing Ma Manxia Lin Peijun Zhang Yishu Wang Qinnan Yan Chu Tao Wen Liu Bin Tang Di Chen Xiaochun Bai Huiling Cao Guozhi Xiao
author_sort	Lei Qin
title	Kindlin-2 mediates mechanotransduction in bone by regulating expression of Sclerostin in osteocytes
title_short	Kindlin-2 mediates mechanotransduction in bone by regulating expression of Sclerostin in osteocytes
title_full	Kindlin-2 mediates mechanotransduction in bone by regulating expression of Sclerostin in osteocytes
title_fullStr	Kindlin-2 mediates mechanotransduction in bone by regulating expression of Sclerostin in osteocytes
title_full_unstemmed	Kindlin-2 mediates mechanotransduction in bone by regulating expression of Sclerostin in osteocytes
title_sort	kindlin-2 mediates mechanotransduction in bone by regulating expression of sclerostin in osteocytes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0c081a3580bc408089962eec2ee0cb9b
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Kindlin-2 mediates mechanotransduction in bone by regulating expression of Sclerostin in osteocytes

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