Herpes Simplex Virus 1 Manipulates Host Cell Antiviral and Proviral DNA Damage Responses

We investigated the relationship between the DNA damage response, a collection of vital cellular pathways that repair potentially lethal damage to the genome, and the DNA virus herpes simplex virus 1. We found that infection by the virus triggers the DNA damage response and key proteins that mediat...

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Autores principales:	Max E. Mertens, David M. Knipe
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/0c0b06f2930b48529bfa962131ab1a62
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spelling	oai:doaj.org-article:0c0b06f2930b48529bfa962131ab1a622021-11-03T18:15:38ZHerpes Simplex Virus 1 Manipulates Host Cell Antiviral and Proviral DNA Damage Responses2161-21292150-751110.1128/mBio.03552-20https://doaj.org/article/0c0b06f2930b48529bfa962131ab1a622021-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.03552-20https://doaj.org/toc/2161-2129https://doaj.org/toc/2150-7511 We investigated the relationship between the DNA damage response, a collection of vital cellular pathways that repair potentially lethal damage to the genome, and the DNA virus herpes simplex virus 1. We found that infection by the virus triggers the DNA damage response and key proteins that mediate this response have opposing effects on the replication and production of progeny viruses.Max E. MertensDavid M. KnipeAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Max E. Mertens David M. Knipe Herpes Simplex Virus 1 Manipulates Host Cell Antiviral and Proviral DNA Damage Responses
description	We investigated the relationship between the DNA damage response, a collection of vital cellular pathways that repair potentially lethal damage to the genome, and the DNA virus herpes simplex virus 1. We found that infection by the virus triggers the DNA damage response and key proteins that mediate this response have opposing effects on the replication and production of progeny viruses.
format	article
author	Max E. Mertens David M. Knipe
author_facet	Max E. Mertens David M. Knipe
author_sort	Max E. Mertens
title	Herpes Simplex Virus 1 Manipulates Host Cell Antiviral and Proviral DNA Damage Responses
title_short	Herpes Simplex Virus 1 Manipulates Host Cell Antiviral and Proviral DNA Damage Responses
title_full	Herpes Simplex Virus 1 Manipulates Host Cell Antiviral and Proviral DNA Damage Responses
title_fullStr	Herpes Simplex Virus 1 Manipulates Host Cell Antiviral and Proviral DNA Damage Responses
title_full_unstemmed	Herpes Simplex Virus 1 Manipulates Host Cell Antiviral and Proviral DNA Damage Responses
title_sort	herpes simplex virus 1 manipulates host cell antiviral and proviral dna damage responses
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/0c0b06f2930b48529bfa962131ab1a62
work_keys_str_mv	AT maxemertens herpessimplexvirus1manipulateshostcellantiviralandproviraldnadamageresponses AT davidmknipe herpessimplexvirus1manipulateshostcellantiviralandproviraldnadamageresponses
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Herpes Simplex Virus 1 Manipulates Host Cell Antiviral and Proviral DNA Damage Responses

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