Amniotic fluid protein profiles of intraamniotic inflammatory response to Ureaplasma spp. and other bacteria.

<h4>Objective</h4>This study aimed to evaluate the amniotic fluid protein profiles and the intensity of intraamniotic inflammatory response to Ureaplasma spp. and other bacteria, using the multiplex xMAP technology.<h4>Methods</h4>A retrospective cohort study was undertaken i...

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Autores principales:	Marian Kacerovsky, Peter Celec, Barbora Vlkova, Kristin Skogstrand, David M Hougaard, Teresa Cobo, Bo Jacobsson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0c135ea47c2f4ccaa59515b73565f3aa
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spelling	oai:doaj.org-article:0c135ea47c2f4ccaa59515b73565f3aa2021-11-18T07:51:51ZAmniotic fluid protein profiles of intraamniotic inflammatory response to Ureaplasma spp. and other bacteria.1932-620310.1371/journal.pone.0060399https://doaj.org/article/0c135ea47c2f4ccaa59515b73565f3aa2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23555967/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>This study aimed to evaluate the amniotic fluid protein profiles and the intensity of intraamniotic inflammatory response to Ureaplasma spp. and other bacteria, using the multiplex xMAP technology.<h4>Methods</h4>A retrospective cohort study was undertaken in the Department of Obstetrics and Gynecology, University Hospital Hradec Kralove, Czech Republic. A total of 145 pregnant women with preterm prelabor rupture of membranes between gestational age 24+0 and 36+6 weeks were included in the study. Amniocenteses were performed. The presence of Ureaplasma spp. and other bacteria was evaluated using 16S rRNA gene sequencing. The levels of specific proteins were determined using multiplex xMAP technology.<h4>Results</h4>The presence of Ureaplasma spp. and other bacteria in the amniotic fluid was associated with increased levels of interleukin (IL)-6, IL-8, IL-10, brain-derived neurotropic factor, granulocyte macrophage colony stimulating factor, monocyte chemotactic protein-1, macrophage inflammatory protein-1, and matrix metalloproteinasis-9. Ureaplasma spp. were also associated with increased levels of neurotropin-3 and triggering receptor expressed on myeloid cells-1.<h4>Conclusions</h4>The presence of Ureaplasma spp. in the amniotic fluid is associated with a slightly different protein profile of inflammatory response, but the intensity of inflammatory response to Ureaplasma spp. is comparable with the inflammatory response to other bacteria.Marian KacerovskyPeter CelecBarbora VlkovaKristin SkogstrandDavid M HougaardTeresa CoboBo JacobssonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e60399 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marian Kacerovsky Peter Celec Barbora Vlkova Kristin Skogstrand David M Hougaard Teresa Cobo Bo Jacobsson Amniotic fluid protein profiles of intraamniotic inflammatory response to Ureaplasma spp. and other bacteria.
description	<h4>Objective</h4>This study aimed to evaluate the amniotic fluid protein profiles and the intensity of intraamniotic inflammatory response to Ureaplasma spp. and other bacteria, using the multiplex xMAP technology.<h4>Methods</h4>A retrospective cohort study was undertaken in the Department of Obstetrics and Gynecology, University Hospital Hradec Kralove, Czech Republic. A total of 145 pregnant women with preterm prelabor rupture of membranes between gestational age 24+0 and 36+6 weeks were included in the study. Amniocenteses were performed. The presence of Ureaplasma spp. and other bacteria was evaluated using 16S rRNA gene sequencing. The levels of specific proteins were determined using multiplex xMAP technology.<h4>Results</h4>The presence of Ureaplasma spp. and other bacteria in the amniotic fluid was associated with increased levels of interleukin (IL)-6, IL-8, IL-10, brain-derived neurotropic factor, granulocyte macrophage colony stimulating factor, monocyte chemotactic protein-1, macrophage inflammatory protein-1, and matrix metalloproteinasis-9. Ureaplasma spp. were also associated with increased levels of neurotropin-3 and triggering receptor expressed on myeloid cells-1.<h4>Conclusions</h4>The presence of Ureaplasma spp. in the amniotic fluid is associated with a slightly different protein profile of inflammatory response, but the intensity of inflammatory response to Ureaplasma spp. is comparable with the inflammatory response to other bacteria.
format	article
author	Marian Kacerovsky Peter Celec Barbora Vlkova Kristin Skogstrand David M Hougaard Teresa Cobo Bo Jacobsson
author_facet	Marian Kacerovsky Peter Celec Barbora Vlkova Kristin Skogstrand David M Hougaard Teresa Cobo Bo Jacobsson
author_sort	Marian Kacerovsky
title	Amniotic fluid protein profiles of intraamniotic inflammatory response to Ureaplasma spp. and other bacteria.
title_short	Amniotic fluid protein profiles of intraamniotic inflammatory response to Ureaplasma spp. and other bacteria.
title_full	Amniotic fluid protein profiles of intraamniotic inflammatory response to Ureaplasma spp. and other bacteria.
title_fullStr	Amniotic fluid protein profiles of intraamniotic inflammatory response to Ureaplasma spp. and other bacteria.
title_full_unstemmed	Amniotic fluid protein profiles of intraamniotic inflammatory response to Ureaplasma spp. and other bacteria.
title_sort	amniotic fluid protein profiles of intraamniotic inflammatory response to ureaplasma spp. and other bacteria.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/0c135ea47c2f4ccaa59515b73565f3aa
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Amniotic fluid protein profiles of intraamniotic inflammatory response to Ureaplasma spp. and other bacteria.

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