Enhanced antifungal efficacy of tebuconazole using gated pH-driven mesoporous nanoparticles

Enhanced antifungal efficacy of tebuconazole using gated pH-driven mesoporous nanoparticles

Núria Mas,1–3 Irene Galiana,3 Silvia Hurtado,† Laura Mondragón,1–3 Andrea Bernardos,1–3 Félix Sancenón,1–3 María D Marcos,1–3 Pedro Amorós,4 Nuria Abril-Utrillas,5 Ram&...

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Autores principales: Mas N, Galiana I, Hurtado S, Mondragón L, Bernardos A, Sancenón F, Marcos MD, Amorós P, Abril-Utrillas N, Martínez-Máñez R, Murguía JR
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2014
Materias:
Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/0c17535797c643a08206b1c12b4caca4
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spelling oai:doaj.org-article:0c17535797c643a08206b1c12b4caca42021-12-02T05:40:29ZEnhanced antifungal efficacy of tebuconazole using gated pH-driven mesoporous nanoparticles1178-2013https://doaj.org/article/0c17535797c643a08206b1c12b4caca42014-05-01T00:00:00Zhttp://www.dovepress.com/enhanced-antifungal-efficacy-of-tebuconazole-using-gated-ph-driven-mes-a16963https://doaj.org/toc/1178-2013 Núria Mas,1–3 Irene Galiana,3 Silvia Hurtado,† Laura Mondragón,1–3 Andrea Bernardos,1–3 Félix Sancenón,1–3 María D Marcos,1–3 Pedro Amorós,4 Nuria Abril-Utrillas,5 Ramón Martínez-Máñez,1–3 José Ramón Murguía1,3 1Centro de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Centro Mixto Universidad Politécnica de Valencia, Universidad de Valencia, Valencia, Spain; 2Departamento de Química, Universidad Politécnica de Valencia, Valencia, Spain; 3CIBER de Bioingeniería, Biomateriales y Nanomedicina, Madrid, Spain; 4Institut de Ciència del Materials (ICMUV), Universitat de València, Valencia, Spain; 5Servicio Ginecología y Obstetricia, Hospital de la Plana, Vila-real, Spain†Silvia Hurtado passed away in September 2013 Abstract: pH-sensitive gated mesoporous silica nanoparticles have been synthesized. Increased extracellular pH and internalization into living yeast cells triggered molecular gate aperture and cargo release. Proper performance of the system was demonstrated with nanodevices loaded with fluorescein or with the antifungal agent tebuconazole. Interestingly, nanodevices loaded with tebuconazole significantly enhanced tebuconazole cytotoxicity. As alterations of acidic external pH are a key parameter in the onset of fungal vaginitis, this nanodevice could improve the treatment for vaginal mycoses.Keywords: capped mesoporous nanoparticles, intracellular release, pH-responsive nanoparticles, Saccharomyces cerevisiae, tebuconazole loadingMas NGaliana IHurtado SMondragón LBernardos ASancenón FMarcos MDAmorós PAbril-Utrillas NMartínez-Máñez RMurguía JRDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 2597-2606 (2014)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Mas N
Galiana I
Hurtado S
Mondragón L
Bernardos A
Sancenón F
Marcos MD
Amorós P
Abril-Utrillas N
Martínez-Máñez R
Murguía JR
Enhanced antifungal efficacy of tebuconazole using gated pH-driven mesoporous nanoparticles
description Núria Mas,1–3 Irene Galiana,3 Silvia Hurtado,† Laura Mondragón,1–3 Andrea Bernardos,1–3 Félix Sancenón,1–3 María D Marcos,1–3 Pedro Amorós,4 Nuria Abril-Utrillas,5 Ramón Martínez-Máñez,1–3 José Ramón Murguía1,3 1Centro de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Centro Mixto Universidad Politécnica de Valencia, Universidad de Valencia, Valencia, Spain; 2Departamento de Química, Universidad Politécnica de Valencia, Valencia, Spain; 3CIBER de Bioingeniería, Biomateriales y Nanomedicina, Madrid, Spain; 4Institut de Ciència del Materials (ICMUV), Universitat de València, Valencia, Spain; 5Servicio Ginecología y Obstetricia, Hospital de la Plana, Vila-real, Spain†Silvia Hurtado passed away in September 2013 Abstract: pH-sensitive gated mesoporous silica nanoparticles have been synthesized. Increased extracellular pH and internalization into living yeast cells triggered molecular gate aperture and cargo release. Proper performance of the system was demonstrated with nanodevices loaded with fluorescein or with the antifungal agent tebuconazole. Interestingly, nanodevices loaded with tebuconazole significantly enhanced tebuconazole cytotoxicity. As alterations of acidic external pH are a key parameter in the onset of fungal vaginitis, this nanodevice could improve the treatment for vaginal mycoses.Keywords: capped mesoporous nanoparticles, intracellular release, pH-responsive nanoparticles, Saccharomyces cerevisiae, tebuconazole loading
format article
author Mas N
Galiana I
Hurtado S
Mondragón L
Bernardos A
Sancenón F
Marcos MD
Amorós P
Abril-Utrillas N
Martínez-Máñez R
Murguía JR
author_facet Mas N
Galiana I
Hurtado S
Mondragón L
Bernardos A
Sancenón F
Marcos MD
Amorós P
Abril-Utrillas N
Martínez-Máñez R
Murguía JR
author_sort Mas N
title Enhanced antifungal efficacy of tebuconazole using gated pH-driven mesoporous nanoparticles
title_short Enhanced antifungal efficacy of tebuconazole using gated pH-driven mesoporous nanoparticles
title_full Enhanced antifungal efficacy of tebuconazole using gated pH-driven mesoporous nanoparticles
title_fullStr Enhanced antifungal efficacy of tebuconazole using gated pH-driven mesoporous nanoparticles
title_full_unstemmed Enhanced antifungal efficacy of tebuconazole using gated pH-driven mesoporous nanoparticles
title_sort enhanced antifungal efficacy of tebuconazole using gated ph-driven mesoporous nanoparticles
publisher Dove Medical Press
publishDate 2014
url https://doaj.org/article/0c17535797c643a08206b1c12b4caca4
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