Role of Au(NPs) in the enhanced response of Au(NPs)-decorated MWCNT electrochemical biosensor

Shahid Mehmood,1 Regina Ciancio,2 Elvio Carlino,2,3 Arshad S Bhatti1 1Department of Physics, Center for Micro and Nano Devices, COMSATS Institute of Information Technology, Islamabad, Pakistan; 2CNR-IOM TASC, Trieste, Italy; 3CNR-IMM, Campus Universitario, Via per Monteroni, Lecce, Italy Backgroun...

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Autores principales:	Mehmood S, Ciancio R, Carlino E, Bhatti AS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Multi-walled Carbon nanotubes (MWCNTs) Au nanoparticles (NPs) Au(NPs)-MWCNTs nanohybrids cyclic voltammetery (CV) electrochemical impedance spectroscopy (EIS) Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0c184edf59ec4e39863b5f93b0ad7f17
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spelling	oai:doaj.org-article:0c184edf59ec4e39863b5f93b0ad7f172021-12-02T00:04:00ZRole of Au(NPs) in the enhanced response of Au(NPs)-decorated MWCNT electrochemical biosensor1178-2013https://doaj.org/article/0c184edf59ec4e39863b5f93b0ad7f172018-04-01T00:00:00Zhttps://www.dovepress.com/role-of-aunps-in-the-enhanced-response-of-aunps-decorated-mwcnt-electr-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Shahid Mehmood,1 Regina Ciancio,2 Elvio Carlino,2,3 Arshad S Bhatti1 1Department of Physics, Center for Micro and Nano Devices, COMSATS Institute of Information Technology, Islamabad, Pakistan; 2CNR-IOM TASC, Trieste, Italy; 3CNR-IMM, Campus Universitario, Via per Monteroni, Lecce, Italy Background: The combination of Au-metallic-NPs and CNTs are a new class of hybrid nanomaterials for the development of electrochemical biosensor. Concentration of Au(nanoparticles [NPs]) in the electrochemical biosensor is crucial for the efficient charge transfer between the Au-NPs-MWCNTs modified electrode and electrolytic solution. Methods: In this work, the charge transfer kinetics in the glassy carbon electrode (GCE) modified with Au(NPs)–multiwalled carbon nanotube (MWCNT) nanohybrid with varied concentrations of Au(NPs) in the range 40–100 nM was studied using electrochemical impedance spectroscopy (EIS). Field emission scanning electron microscopy and transmission electron microscopy confirmed the attachment of Au(NPs) on the surface of MWCNTs. Results: The cyclic voltammetry and EIS results showed that the charge transfer mechanism was diffusion controlled and the rate of charge transfer was dependent on the concentration of Au(NPs) in the nanohybrid. The formation of spherical diffusion zone, which was dependent on the concentration of Au(NPs) in nanohybrids, was attributed to result in 3 times the increase in the charge transfer rate ks, 5 times increase in mass transfer, and 5% (9%) increase in Ipa (Ipc) observed in cyclic voltammetry in 80 nM Au(NP) nanohybrid-modified GCE from MWCNT-modified GCE. The work was extended to probe the effect of charge transfer rates at various concentrations of Au(NPs) in the nanohybrid-modified electrodes in the presence of Escherichia coli. The cyclic voltammetry results clearly showed the best results for 80 nM Au(NPs) in nanohybrid electrode. Conclusion: The present study suggested that the formation of spherical diffusion zone in nanohybrid-modified electrodes is critical for the enhanced electrochemical biosensing applications. Keywords: multiwalled carbon nanotubes, Au nanoparticle–MWCNT nanohybrids, cyclic voltammetery, electrochemical impedance spectroscopyMehmood SCiancio RCarlino EBhatti ASDove Medical PressarticleMulti-walled Carbon nanotubes (MWCNTs)Au nanoparticles (NPs)Au(NPs)-MWCNTs nanohybridscyclic voltammetery (CV)electrochemical impedance spectroscopy (EIS)Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 2093-2106 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Multi-walled Carbon nanotubes (MWCNTs) Au nanoparticles (NPs) Au(NPs)-MWCNTs nanohybrids cyclic voltammetery (CV) electrochemical impedance spectroscopy (EIS) Medicine (General) R5-920
spellingShingle	Multi-walled Carbon nanotubes (MWCNTs) Au nanoparticles (NPs) Au(NPs)-MWCNTs nanohybrids cyclic voltammetery (CV) electrochemical impedance spectroscopy (EIS) Medicine (General) R5-920 Mehmood S Ciancio R Carlino E Bhatti AS Role of Au(NPs) in the enhanced response of Au(NPs)-decorated MWCNT electrochemical biosensor
description	Shahid Mehmood,1 Regina Ciancio,2 Elvio Carlino,2,3 Arshad S Bhatti1 1Department of Physics, Center for Micro and Nano Devices, COMSATS Institute of Information Technology, Islamabad, Pakistan; 2CNR-IOM TASC, Trieste, Italy; 3CNR-IMM, Campus Universitario, Via per Monteroni, Lecce, Italy Background: The combination of Au-metallic-NPs and CNTs are a new class of hybrid nanomaterials for the development of electrochemical biosensor. Concentration of Au(nanoparticles [NPs]) in the electrochemical biosensor is crucial for the efficient charge transfer between the Au-NPs-MWCNTs modified electrode and electrolytic solution. Methods: In this work, the charge transfer kinetics in the glassy carbon electrode (GCE) modified with Au(NPs)–multiwalled carbon nanotube (MWCNT) nanohybrid with varied concentrations of Au(NPs) in the range 40–100 nM was studied using electrochemical impedance spectroscopy (EIS). Field emission scanning electron microscopy and transmission electron microscopy confirmed the attachment of Au(NPs) on the surface of MWCNTs. Results: The cyclic voltammetry and EIS results showed that the charge transfer mechanism was diffusion controlled and the rate of charge transfer was dependent on the concentration of Au(NPs) in the nanohybrid. The formation of spherical diffusion zone, which was dependent on the concentration of Au(NPs) in nanohybrids, was attributed to result in 3 times the increase in the charge transfer rate ks, 5 times increase in mass transfer, and 5% (9%) increase in Ipa (Ipc) observed in cyclic voltammetry in 80 nM Au(NP) nanohybrid-modified GCE from MWCNT-modified GCE. The work was extended to probe the effect of charge transfer rates at various concentrations of Au(NPs) in the nanohybrid-modified electrodes in the presence of Escherichia coli. The cyclic voltammetry results clearly showed the best results for 80 nM Au(NPs) in nanohybrid electrode. Conclusion: The present study suggested that the formation of spherical diffusion zone in nanohybrid-modified electrodes is critical for the enhanced electrochemical biosensing applications. Keywords: multiwalled carbon nanotubes, Au nanoparticle–MWCNT nanohybrids, cyclic voltammetery, electrochemical impedance spectroscopy
format	article
author	Mehmood S Ciancio R Carlino E Bhatti AS
author_facet	Mehmood S Ciancio R Carlino E Bhatti AS
author_sort	Mehmood S
title	Role of Au(NPs) in the enhanced response of Au(NPs)-decorated MWCNT electrochemical biosensor
title_short	Role of Au(NPs) in the enhanced response of Au(NPs)-decorated MWCNT electrochemical biosensor
title_full	Role of Au(NPs) in the enhanced response of Au(NPs)-decorated MWCNT electrochemical biosensor
title_fullStr	Role of Au(NPs) in the enhanced response of Au(NPs)-decorated MWCNT electrochemical biosensor
title_full_unstemmed	Role of Au(NPs) in the enhanced response of Au(NPs)-decorated MWCNT electrochemical biosensor
title_sort	role of au(nps) in the enhanced response of au(nps)-decorated mwcnt electrochemical biosensor
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/0c184edf59ec4e39863b5f93b0ad7f17
work_keys_str_mv	AT mehmoods roleofaunpsintheenhancedresponseofaunpsdecoratedmwcntelectrochemicalbiosensor AT ciancior roleofaunpsintheenhancedresponseofaunpsdecoratedmwcntelectrochemicalbiosensor AT carlinoe roleofaunpsintheenhancedresponseofaunpsdecoratedmwcntelectrochemicalbiosensor AT bhattias roleofaunpsintheenhancedresponseofaunpsdecoratedmwcntelectrochemicalbiosensor
_version_	1718403907998187520

Role of Au(NPs) in the enhanced response of Au(NPs)-decorated MWCNT electrochemical biosensor

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