The association between cortisol:C-reactive protein ratio and depressive fatigue is a function of CRP rather than cortisol

Christopher F Sharpley,1 Vicki Bitsika,1 Mary E McMillan,1 Emmanuel Jesulola,2 Linda L Agnew11Brain-Behaviour Research Group, University of New England, Armidale, NSW 2351, Australia; 2Emergency Department, Bathurst Base Hospital, Bathurst, NSW 2795, AustraliaCorrespondence: Christopher F SharpleyBr...

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Autores principales:	Sharpley CF, Bitsika V, McMillan ME, Jesulola E, Agnew LL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Depression fatigue CRP cortisol Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/0c1abba5e4104b15b29f640de3aef2b0
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spelling	oai:doaj.org-article:0c1abba5e4104b15b29f640de3aef2b02021-12-02T03:21:50ZThe association between cortisol:C-reactive protein ratio and depressive fatigue is a function of CRP rather than cortisol1178-2021https://doaj.org/article/0c1abba5e4104b15b29f640de3aef2b02019-08-01T00:00:00Zhttps://www.dovepress.com/the-association-between-cortisolc-reactive-protein-ratio-and-depressiv-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Christopher F Sharpley,1 Vicki Bitsika,1 Mary E McMillan,1 Emmanuel Jesulola,2 Linda L Agnew11Brain-Behaviour Research Group, University of New England, Armidale, NSW 2351, Australia; 2Emergency Department, Bathurst Base Hospital, Bathurst, NSW 2795, AustraliaCorrespondence: Christopher F SharpleyBrain-Behaviour Research Group, University of New England, Queen Elizabeth Drive, Armidale, NSW 2350, AustraliaTel +61 26 773 2596Email csharpl3@une.edu.auPurpose: Hormonal and inflammatory factors have been suggested as potentially influencing depressive state and depressive symptoms, but rarely compared for their relative contribution to these states and to specific depressive symptoms. This study examined cortisol:C-reactive protein (CRP) ratio, plus cortisol and CRP separately, as correlates of global depression and fatigue-related depression.Patients and methods: One hundred and twenty-six community volunteers from rural Australia provided saliva and serum samples, and also completed a depression inventory.Results: There was a significant correlation between cortisol:CRP ratio and depression-related fatigue, and this resolved to the effects of CRP rather than cortisol. Most of the variance in this association came from patients who were “depressed”, and there were no significant gender associations.Conclusion: Inflammation, rather than HPA-axis activity, was associated with depression-related fatigue, supporting a model that places inflammation as a contributor to one of the major symptoms and predictors of depression. Individualization of therapy for depression-related fatigue in chronically stressed or physically ill patients might benefit from future research into cytokine therapy.Keywords: depression, fatigue, CRP, cortisolSharpley CFBitsika VMcMillan MEJesulola EAgnew LLDove Medical PressarticleDepressionfatigueCRPcortisolNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 2467-2475 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Depression fatigue CRP cortisol Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Depression fatigue CRP cortisol Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Sharpley CF Bitsika V McMillan ME Jesulola E Agnew LL The association between cortisol:C-reactive protein ratio and depressive fatigue is a function of CRP rather than cortisol
description	Christopher F Sharpley,1 Vicki Bitsika,1 Mary E McMillan,1 Emmanuel Jesulola,2 Linda L Agnew11Brain-Behaviour Research Group, University of New England, Armidale, NSW 2351, Australia; 2Emergency Department, Bathurst Base Hospital, Bathurst, NSW 2795, AustraliaCorrespondence: Christopher F SharpleyBrain-Behaviour Research Group, University of New England, Queen Elizabeth Drive, Armidale, NSW 2350, AustraliaTel +61 26 773 2596Email csharpl3@une.edu.auPurpose: Hormonal and inflammatory factors have been suggested as potentially influencing depressive state and depressive symptoms, but rarely compared for their relative contribution to these states and to specific depressive symptoms. This study examined cortisol:C-reactive protein (CRP) ratio, plus cortisol and CRP separately, as correlates of global depression and fatigue-related depression.Patients and methods: One hundred and twenty-six community volunteers from rural Australia provided saliva and serum samples, and also completed a depression inventory.Results: There was a significant correlation between cortisol:CRP ratio and depression-related fatigue, and this resolved to the effects of CRP rather than cortisol. Most of the variance in this association came from patients who were “depressed”, and there were no significant gender associations.Conclusion: Inflammation, rather than HPA-axis activity, was associated with depression-related fatigue, supporting a model that places inflammation as a contributor to one of the major symptoms and predictors of depression. Individualization of therapy for depression-related fatigue in chronically stressed or physically ill patients might benefit from future research into cytokine therapy.Keywords: depression, fatigue, CRP, cortisol
format	article
author	Sharpley CF Bitsika V McMillan ME Jesulola E Agnew LL
author_facet	Sharpley CF Bitsika V McMillan ME Jesulola E Agnew LL
author_sort	Sharpley CF
title	The association between cortisol:C-reactive protein ratio and depressive fatigue is a function of CRP rather than cortisol
title_short	The association between cortisol:C-reactive protein ratio and depressive fatigue is a function of CRP rather than cortisol
title_full	The association between cortisol:C-reactive protein ratio and depressive fatigue is a function of CRP rather than cortisol
title_fullStr	The association between cortisol:C-reactive protein ratio and depressive fatigue is a function of CRP rather than cortisol
title_full_unstemmed	The association between cortisol:C-reactive protein ratio and depressive fatigue is a function of CRP rather than cortisol
title_sort	association between cortisol:c-reactive protein ratio and depressive fatigue is a function of crp rather than cortisol
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/0c1abba5e4104b15b29f640de3aef2b0
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The association between cortisol:C-reactive protein ratio and depressive fatigue is a function of CRP rather than cortisol

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